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This research analyzes for the first time in the Pacific Tropical-Subtropical Convergence off Mexico during June 2010 the relationships among the δ 13 C and δ 15 N signal distribution in the bulk zooplankton, water masses, and mesoscale structures. The environmental analysis showed that the California Current Water (CCW) and Transitional Water (TrW) converge where the 22 °C isotherm and 34.6 g kg -1 isohaline were observed (22°N). Two cyclonic eddies were detected: one in CCW at 24°N about 70 km in diameter, the other one located in TrW at 21°N with 150 km in diameter. A cluster analysis defined three zooplankton isoscapes with significant differences. Isoscape 1, immerses in CCW - the lowest δ 13 C (-22.37 ± 0.89 ‰) and δ 15 N (9.89 ± 1.32 ‰) - showed temperature (19.86 ± 1.97 °C), salinity (34.08 ± 0.37 g kg -1 ) values, the deepest thermocline (77.93 ± 25.51 m) and oxygen minimum zone (164.78 ± 44.96 m). The CCW was relatively oligotrophic without important mesoscale features in the sampled time within the sampled area. Isoscape 2, a cyclonic eddy in CCW - relatively enriched zooplankton δ 13 C values (-16.78 ± 1.95 ‰) due to the entry of enriched coastal biota- reflected in high chlorophyll a and subsequently assimilated into zooplankton tissues. Isoscape 3, a cyclonic eddy immerses in TrW - the highest δ 15 N (13.14 ± 1.60 ‰), salinity (34.76 ± 0.19 g kg -1 ) and temperature (19.90 ± 2.27 °C) values and shallowest thermocline (32.27 ± 18.63 m), and oxygen minimum zone (66.82 ± 37.68 m) in depth. Likely, this 15 N-enriched recycled nitrate was pumped from the deoxygenated subsurface to the surface, reflected in the zooplankton bulks. The results showed that the isotopic signals in bulk zooplankton may be a good water mass and mesoscale activity tracer., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Regional ecological patterns, distribution and population structure of Prionace glauca were analyzed based on samples collected on-board two long-line fleets operating in oceanic waters (1994-96/2000-02) and in coastal oceanic waters (2003-2009) of the eastern tropical Pacific off México. Generalized additive models were applied to catch per unit of effort data to evaluate the effect of spatial, temporal and environmental factors on the horizontal distribution of the life stages (juvenile, adult) and the sexes at the estimated depth of catch. The presence of breeding areas was explored. The population structure was characterized by the presence of juveniles' aggregations and pregnant females towards coastal waters and the presence of adult males' aggregations towards oceanic waters. The species exhibited horizontal segregation by sex-size and vertical segregation by sex. Distribution of the sex-size groups at oceanic waters was seasonally affected by the latitude; however, at coastal oceanic waters mainly females were influenced by the longitude. Latitudinal changes on the horizontal distribution were coupled to the seasonal forward and backward of water masses through the study area. Adult males showed positive relationship with high temperatures and high-salinities waters (17.0°-20.0 °C; 34.2-34.4) although they were also detected in low-salinities waters. The distribution of juvenile males mainly occurred beyond low temperatures and low-salinities waters (14.0°-15.0 °C; 33.6-34.1), suggesting a wide tolerance of adult males to explore subartic and subtropical waters. At oceanic areas, adult females were aggregated towards latitudes <25.0°N, mainly associated to subtropical waters during summer. The distribution of juvenile females indicated its preference by lower temperatures and more saline waters. Presence of pregnant females suggests that the eastern tropical Pacific off México represents an ecological key region to the reproductive cycle of P. glauca., (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Llamas, South American Camelids are increasingly popular in the United States, as a source of fiber, livestock guard, and pack animals. Gastrointestinal parasites have been identified as a major health problem in all classes of livestock including llamas. Currently, there are no approved anthelmintics available for use in llamas. In this study, the pharmacokinetics of a single, oral administration of fenbendazole paste at a minimum target dose of 5mg/kg, with an upper limit of <10mg/kg, was evaluated in llamas. Plasma fenbendazole concentration time profiles were best described by a single compartment model. After oral administration of fenbendazole, T(max) and Cp(max) were 28.39+/-12.80h, and 0.28+/-0.17µg/ml, respectively. The T(1/2alpha) and T(1/2beta) were 16.25+/-11.67 and 36.00+/-25.00h, respectively. The apparent volume of distribution (V(d)) and the area under the curve (AUC) were 11.28+/-4.66l/kg, and 22.52+/-8.67µgh/ml, respectively. The results of this preliminary study indicate that when the paste formulation of fenbendazole is administered orally to llamas, its rate of absorption appears to be very similar to that of other ruminants including sheep, goats, and cattle as indicated by the time required to reach peak plasma concentrations. It was also found that the rate of elimination of fenbendazole was prolonged in llamas as compared to sheep, goats, and cattle.

Parathyroid cell proliferation and parathyroid hyperplasia are features of renal secondary hyperparathyroidism. Since parathyroids have recently been recognized as an important target for 1,25(OH)2D3, the effects of administration of variable doses of 1,25(OH)2D3 on ex vivo radiothymidine incorporation in the parathyroid glands, on parathyroid cell mitoses, on parathyroid weight, morphometric indices and on parathyroid protein/DNA ratio were examined in rats with uremia (subtotal nephrectomy; NX) or with calcium deficiency. 3H-thymidine incorporation (3 hr; 37 degrees C; PBS with 10 mmol glucose) was elevated in NX animals, that is, 204 +/- 51 dpm/micrograms DNA versus 96 +/- 28 in controls. In vivo pretreatment with 1,25(OH)2D3, either by intermittent i.p. injection or by osmotic minipump, dose-dependently decreased 3H-thymidine incorporation and parathyroid cell mitoses without affecting morphometric indices of parathyroid cells. Prophylactic administration (i.p.) of 1,25(OH)2D3, starting on the day of nephrectomy, prevented parathyroid hyperplasia (NX + 1,25(OH)2D3 0.84 micrograms tissue/g body wt vs. 1.25 micrograms in untreated NX and 0.54 in ad libitum fed controls), but 10 days of treatment beginning on the 21st day of uremia did not reverse existing hyperplasia (NX + 1,25(OH)2D3 1.5 micrograms/g body wt vs. 1.37 micrograms in untreated NX and 0.56 micrograms in ad libitum fed controls). The inhibitory effect was specific for 1,25(OH)2D3 and not imitated by Dexamethason. However, the effect was not specific for parathyroid hyperplasia of uremia, since similar inhibition of 3H-thymidine incorporation by 1,25(OH)2D3 was also observed in rats on low calcium diet.(ABSTRACT TRUNCATED AT 250 WORDS)