1. Differential expression of the nm23 genes in the developing human trophoblast.
- Author
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Guyon F, Marnet B, Arnaud-Dabernat S, Carles D, Mathieu C, Saura R, Perel Y, Horovitz J, Landry M, Bischof P, and Daniel JY
- Subjects
- Embryonic and Fetal Development physiology, Eye Proteins metabolism, Female, Gestational Age, Humans, Immunohistochemistry, In Situ Hybridization, Ki-67 Antigen analysis, NM23 Nucleoside Diphosphate Kinases, Nerve Tissue Proteins metabolism, Nucleoside-Diphosphate Kinase metabolism, Pregnancy, Gene Expression Regulation, Developmental genetics, Nucleoside-Diphosphate Kinase genetics, Trophoblasts enzymology
- Abstract
NDP kinases are the non-specific enzymes which catalyse the synthesis of the NTPs through a transfer reaction using ATP as phosphoryl donor. In addition to their enzymatic activity, they display other not yet explained functions related to cell growth, differentiation and apoptosis, embryonic development, tumour progression and metastasis. In this study, the expression patterns of the three highly related NDP kinases A, B and C isoforms were investigated in the developing human trophoblast. Both NDP kinase A and B were found to be primarily present in the villous and extravillous cytotrophoblasts, while NDP kinase C was found almost exclusively in the syncytiotrophoblast layer. This suggests that NDP kinase A and B could be a marker for the mononuclear stage of differentiation of villous trophoblasts, while NDP kinase C could be a marker of the syncytiotrophoblast layer.
- Published
- 2004
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