1. Disruption of the Sensory System Affects Sterile Cutaneous Inflammation In Vivo.
- Author
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La Russa F, Lopes DM, Hobbs C, Argunhan F, Brain S, Bevan S, Bennett DLH, and McMahon SB
- Subjects
- Animals, Calcitonin Gene-Related Peptide genetics, Dendritic Cells immunology, Disease Models, Animal, Diterpenes toxicity, Female, Humans, Mice, Mice, Knockout, Nerve Fibers drug effects, Nerve Fibers immunology, Nerve Fibers metabolism, Neurotoxins toxicity, Nociceptors drug effects, Nociceptors metabolism, Skin cytology, Skin immunology, Skin innervation, TRPA1 Cation Channel genetics, TRPA1 Cation Channel metabolism, TRPV Cation Channels antagonists & inhibitors, TRPV Cation Channels genetics, TRPV Cation Channels metabolism, Ultraviolet Rays adverse effects, Calcitonin Gene-Related Peptide metabolism, Dermatitis immunology, Nociceptors immunology, Skin radiation effects, Sunburn immunology
- Abstract
Increasing evidence suggests that nerve fibers responding to noxious stimuli (nociceptors) modulate immunity in a variety of tissues, including the skin. Yet, the role of nociceptors in regulating sterile cutaneous inflammation remains unexplored. To address this question, we have developed a detailed description of the sterile inflammation caused by overexposure to UVB irradiation (i.e., sunburn) in the mouse plantar skin. Using this model, we observed that chemical depletion of nociceptor terminals did not alter the early phase of the inflammatory response to UVB, but it caused a significant increase in the number of dendritic cells and αβ
+ T cells as well as enhanced extravasation during the later stages of inflammation. Finally, we showed that such regulation was driven by the nociceptive neuropeptide calcitonin gene-related peptide. In conclusion, we propose that nociceptors not only play a crucial role in inflammation through avoidance reflexes and behaviors, but can also regulate sterile cutaneous immunity in vivo., (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2019
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