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Objectives: To identify potential modulators of OHRQoL in patients with maxillary implant-retained overdentures using specific implant-prosthesis questionnaires., Methods: In this cross-sectional observational study, 70 volunteers with maxillary implant overdentures were divided into two balanced groups (n=35 each) concerning gender and partnership status. The participants completed the QoLIP-10, QoLDAS-9, and QoLFAST-10 scales. Sociodemographic, clinical, and prosthesis-related variables were gathered. Descriptive statistics and non-parametric probes (Chi-square, Kruskal-Wallis, Mann-Whitney U tests, and Spearman rho correlation) were used to assess potential modulators of patient satisfaction (α = 0.05)., Results: Concerning the influence of gender, women reported the greatest satisfaction, as evidenced by the QoLIP-10 Performance domain (item 9), and the QoLDAS-9 total score and both its Psycho-facial and Interactive domains. Regarding the partnership status, unpartnered patients showed the significantly highest satisfaction, as indicated by the QoLDAS-9 Sociodental domain (item 7) and the both the QoLFAST-10 total and Social dimensional scores. Significant improvements in OHRQoL associated with higher retention, stability, and aesthetics of the implant overdenture were indicated by both the QoLFAST-10 and QoLDAS-9 questionnaires. No correlation was observed between the study groups in terms of the OHRQoL revealed by the total scores for each scale., Conclusions: The QoLIP-10, QoLDAS-9, and QoLFAST-10 specific questionnaires consistently pointed to a better satisfaction of women and unpartnered patients wearing maxillary implant overdentures. Aesthetic, functional, and social factors also influenced the assessment of the patients' wellbeing., Clinical Significance: Specific questionnaires are effective tools for identifying sociodemographic and clinical OHRQoL modulators, to accurately assess the success chances of implant overdenture rehabilitations., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)