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1. Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points

Author

Henry F. Duncan, Anthony J. Smith, Garry J.P. Fleming, Gary P. Moran, and Paul R. Cooper

Subjects
Genetics, QH426-470
Abstract

Dental pulp tissue can be damaged by a range of irritants, however, if the irritation is removed and/or the tooth is adequately restored, pulp regeneration is possible (Mjör and Tronstad, 1974 [1]). At present, dental restorative materials limit healing by impairing mineralization and repair processes and as a result new biologically-based materials are being developed (Ferracane et al., 2010 [2]). Previous studies have highlighted the benefit of epigenetic modification by histone deacetylase inhibitor (HDACi) application to dental pulp cells (DPCs), which induces changes to chromatin architecture, promoting gene expression and cellular-reparative events (Duncan et al., 2013 [3]; Paino et al., 2014 [4]). In this study a genome-wide transcription profiling in epigenetically-modified mineralizing primary DPC cultures was performed, at relatively early and late time-points, to identify differentially regulated transcripts that may provide novel therapeutic targets for use in restorative dentistry. Here we provide detailed methods and analysis on these microarray data which has been deposited in Gene Expression Omnibus (GEO): GSE67175.

Published
2015
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3. List of contributors

Author

Masashi Abe, Jon D. Ahlstrom, Julie Albon, Julie Allickson, Graça Almeida-Porada, Richard A. Altschuler, Daniel G. Anderson, Nasim Annabi, Judith Arcidiacono, Nureddin Ashammakhi, Anthony Atala, Kyriacos A. Athanasiou, Hani A. Awad, Stephen F Badylak, Gowri Balachander, Wayne Balkan, Jennifer J. Bara, Michael P. Barry, Harihara Baskaran, Matthew L. Bedell, Donald Andrew Belcher, David B. Berry, Hina Bhat, Zuhaib F. Bhat, Sangeeta N. Bhatia, Catherine Clare Blackburn, Anna Blocki, Kevin M. Blum, Matthew A. Bochenek, Lawrence J. Bonassar, Joseph V. Bonventre, Mimi R. Borrelli, Robby D. Bowles, Amy D. Bradshaw, Andres M. Bratt-Leal, Christopher K. Breuer, Luke Brewster, Eric M. Brey, Priscilla S. Briquez, J.A. Buckwalter, Karen J.L. Burg, Timothy C. Burg, Batzaya Byambaa, Prafulla K. Chandra, Amanda X. Chen, Fa-Ming Chen, Shaochen Chen, Julian Chesterman, Arnav Chhabra, Seow Khoon Chong, Richard A.F. Clark, Muriel A. Cleary, M. Coleman, George Cotsarelis, Ronald G. Crystal, Gislin Dagnelie, Mohammad Ali Darabi, Jeffrey M. Davidson, Joseph Davidson, Paolo De Coppi, Derfogail Delcassian, Paul de Vos, Anthony Dominijanni, Ryan Donahue, Allison P. Drain, Craig L. Duvall, Jenna L. Dziki, Abdelmotagaly Elgalad, George Eng, Vincent Falanga, Niloofar Farhang, Lino Ferreira, Donald W. Fink, Heather E. Fleming, Peter Fong, Mark R. Frey, Denise Gay, Sharon Gerecht, Charles A. Gersbach, D.M.R. Gibbs, Simran Gidwani, Shaimar R. González Morales, Ritu Goyal, Maria B. Grant, Andrea Gray, Howard P. Greisler, Tracy C. Grikscheit, Karl Grosh, Farshid Guilak, Jason L. Guo, Yingli Han, Joshua M. Hare, Ammar Mansoor Hassanbhai, Konstantinos Hatzistergos, David C. Hay, Xiao-Tao He, Timothy Henderson, Darren Hickerson, Darren H.M. Hickerson, Abdelkrim Hmadcha, Camila Hochman-Mendez, Chao Huang, Jeffrey A. Hubbell, Joern Huelsmann, Jun Tae Huh, Joshua G. Hunsberger, Leanne E. Iannucci, Haruhisa Inoue, John Jackson, Yangzi Jiang, Vladimir V. Kalinichenko, J.M. Kanczler, Jeffrey M. Karp, F. Kurtis Kasper, Ali Khademhosseini, Ji Hyun Kim, Erin A. Kimbrel, Irina Klimanskaya, Joachim Kohn, Sunil Kumar, Themis R. Kyriakides, Spencer P. Lake, Johnny Lam, Robert Langer, Robert Lanza, Timothy S. Leach, Benjamin W. Lee, Iris Lee, Sang Jin Lee, David Li, Linheng Li, Qian Liu, Alexander V. Ljubimov, Chi Lo, Michael T. Longaker, Javier López-Beas, Jeanne F. Loring, Ying Luo, Ben D. MacArthur, Nicolas N. Madigan, Henning Madry, Renata S. Magalhaes, Nancy Ruth Manley, Jonathan Mansbridge, Jeremy J. Mao, K.M. Marshall, J.A. Martin, M. Martins-Green, Kathryn M. Maselli, Mark W. Maxfield, Kyle W. McCracken, James Melville, Antonios G. Mikos, José del R. Millán, Maria Mirotsou, Daniel T. Montoro, Matthew P. Murphy, Sean V. Murphy, Michael Musillo, Padmalosini Muthukumaran, Adam M. Navara, Christopher E. Nelson, Laura E. Niklason, Craig Scott Nowell, Regis J. O’Keefe, Kathy E. O’Neill, Richard O.C. Oreffo, Ophir Ortiz, Andre Francis Palmer, Serafeim Perdikis, M. Petreaca, Maksim V. Plikus, Christopher D. Porada, Mark Post, Aleš Prokop, Raj K. Puri, Pengxu Qian, Milica Radisic, Micha Sam Brickman Raredon, Ellen Rothman Richie, Paul Rouse, Hooman Sadri-Ardekani, W. Mark Saltzman, Luiz C. Sampaio, Christopher R. Schlieve, Su-Hua Sha, Paul T. Sharpe, V. Prasad Shastri, Yanhong Shi, Thomas Shupe, Dario Sirabella, Aleksander Skardal, J.M.W. Slack, Stephen R. Sloan, Shay Soker, Bernat Soria, Bárbara Soria-Juan, Frank E. Stockdale, Josh Stover, Thomas Stransky, H. Christiaan Stronks, Patrick S. Stumpf, Kyung Eun Sung, Daniel Swarr, Dagmara Szkolnicka, Jun Takahashi, D.K.O. Tang, Winson Tang, Doris A. Taylor, Yao Teng, Swee Hin Teoh, Anthony J. Smith, Elsa Treffeisen, Rocky S. Tuan, Joseph P. Vacanti, Cor van der Weele, Matthew Vincent, Gordana Vunjak-Novakovic, Lars U. Wahlberg, Derrick C. Wan, Anne Wang, Dan Wang, Qiwei Wang, Yanling Wang, Yu-li Wang, Zhanwen Wang, Valerie M. Weaver, J.A. Wells, Jean F. Welter, Feng Wen, Jake Weston, Jeffrey A. Whitsett, James K. Williams, Anthony J. Windebank, Mark Eu-Kien Wong, Stefan Worgall, Iwen Wu, Rui-Xin Wu, Virginia Y. Xie, Malcolm Xing, Kenneth M. Yamada, Shinya Yamanaka, James J. Yoo, Simon Young, Claire Yu, Hanry Yu, Yifan Yuan, William Zacharias, Jason Zakko, Ai Zhang, Yuanyuan Zhang, Zheng Zhang, Chunfeng Zhao, Yimu Zhao, and Laurie Zoloth

Published
2020

4. Biological tooth replacement and repair

Author

Anthony J. Smith and Paul T. Sharpe

Subjects
Enamel paint, Chemistry, business.industry, Dentistry, medicine.disease, Dental treatments, Biological repair, stomatognathic diseases, stomatognathic system, visual_art, Oral and maxillofacial pathology, visual_art.visual_art_medium, Medicine, business
Abstract

Teeth might not at first seem an obvious organ for which to develop biological methods for replacement or repair. Teeth are non-essential organs, and modern dental treatments enable most dental problems to be treated using traditional non-biological approaches. They do, however, offer unique opportunities to develop tissue-engineering-based approaches on an organ that is not only easily accessible and non-life-threatening but one where there are very large patient numbers and a significant clinical problem. Although there are an increasing number of alternative treatments in dentistry, most are non-biological and many are based on techniques that have been practiced for thousands of years. The possibility that repair of dental hard tissues (dentine and enamel) might involve the use of cells to remineralize the damage to teeth naturally is an exciting prospect. This chapter explores the current status of research directed toward whole tooth replacement and repair of dental disease.

Published
2020

6. Cellular Signaling in Dentin Repair and Regeneration

Author

Anthony J. Smith and Paul R. Cooper

Subjects
medicine.medical_specialty, Cell signaling, business.industry, Inflammation, Cell biology, Surgery, stomatognathic diseases, Cytokine stimulation, medicine.anatomical_structure, Odontoblast, stomatognathic system, medicine, Dentin, Pulp (tooth), Cellular secretion, medicine.symptom, Progenitor cell, business
Abstract

Injury to the dentin-pulp complex results in a variety of cellular responses that determine tooth vitality and survival. Initially, these responses center on the odontoblasts as the first line of defense and environmental sensors, but will subsequently encompass other cells in the pulp with a complex interplay being seen between regenerative responses involving odontoblasts and the inflammation associated with pulpal responses to injury. Local degradation of dentin matrix following injury will release bioactive molecules contributing to cellular signaling. While tissue repair and regeneration will likely occur only when infection and inflammation are under control, low-level cytokine stimulation during the earlier stages of dental disease, and possibly as resolution of inflammation ensues, may facilitate and promote reparative events. Whether odontoblasts survive the injurious challenge will determine if reactionary or reparative dentinogenesis occurs during repair and regeneration in the dentin-pulp complex. Notably the complexity of cellular responses is significantly greater for reparative dentinogenesis where stem/progenitor cell recruitment and induction of differentiation are required prior to up-regulation of cellular secretion of new matrix. Angiogeneic and neurogenic signaling are also important events during repair and regeneration. Improved understanding of cellular signaling following tooth injury helps underpin our approaches to diagnosis and treatment planning, as well as driving novel strategies for translation of new clinical therapeutic approaches.

Published
2015

7. CONTRIBUTORS

Author

Jon D. Ahlstrom, Richard A. Altschuler, A. Amendola, David J. Anderson, Piero Anversa, Anthony Atala, Kyriacos A. Athanasiou, François A. Auger, Debra T. Auguste, Claudia Bearzi, Daniel Becker, Francisco J. Bedoya, Eugene Bell, Timothy Bertram, Valérie Besnard, Christopher J. Bettinger, Sangeeta N. Bhatia, Paolo Bianco, Anne E. Bishop, C. Clare Blackburn, Michael P. Bohrer, Roberto Bolli, Lawrence J. Bonassar, Jeffrey T. Borenstein, Michael E. Boulton, Amy D. Bradshaw, Luke Brewster, Eric M. Brey, Mairi Brittan, T. Brown, Scott P. Bruder, Joseph A. Buckwalter, Christopher Cannizzaro, Yilin Cao, Lamont Cathey, Thomas M.S. Chang, Yunchao Chang, Robert G. Chapman, Alice A. Chen, Faye H. Chen, Una Chen, Richard A.F. Clark, Clark K. Colton, Stephen C. Cowin, Ronald Crystal, Gislin Dagnelie, Jeffrey M. Davidson, Thomas F. Deuel, Elizabeth Deweerd, Gregory R. Dressler, George C. Engelmayr, Carol A. Erickson, Thomas Eschenhagen, Vincent Falanga, Katie Faria, Denise L. Faustman, Dario O. Fauza, Lino da Silva Ferreira, Hanson K. Fong, Peter Fong, Lisa E. Freed, R.I. Freshney, Mark E. Furth, Jeffrey Geesin, Sharon Gerecht, Lucie Germain, Kaustabh Ghosh, William V. Giannobile, Francine Goulet, Maria B. Grant, Warren Grayson, Howard P. Greisler, Farshid Guilak, Craig Halberstadt, Brendan Harley, Kiki B. Hellman, Abdelkrim Hmadcha, Steve J. Hodges, Walter D. Holder, Chantal E. Holy, Toru Hosoda, Jeffrey A. Hubbell, H. David Humes, Donald E. Ingber, Ana Jaklenec, Hee-Sook Jun, Jan Kajstura, Ravi S. Kane, Jeffrey M. Karp, John Kay, Ali Khademhosseini, Salman R. Khetani, Joachim Kohn, Shaun M. Kunisaki, Matthew D. Kwan, Themis R. Kyriakides, Eric Lagasse, Robert Langer, Douglas A. Lauffenburger, Kuen Yong Lee, Annarosa Leri, David W. Levine, Amy S. Lewis, Wan-Ju Li, Wei Liu, Michael T. Longaker, Ying Luo, Michael J. Lysaght, Nancy Ruth Manley, Jonathan Mansbridge, J.L. Marsh, David C. Martin, J.A. Martin, Manuela Martins-Green, Koichi Masuda, Robert L. Mauck, John W. McDonald, Antonios G. Mikos, Josef M. Miller, David J. Mooney, Malcolm A.S. Moore, Matthew B. Murphy, Robert M. Nerem, William Nikovits, Craig Scott Nowell, Bojana Obradovic, Bjorn R. Olsen, James M. Pachence, Hyoungshin Park, Jason Park, M. Petreaca, Julia M. Polak, A. Robin Poole, Christopher S. Potten, Ales Prokop, Milica Radisic, Yehoash Raphael, A. Hari Reddi, Herrmann Reichenspurner, Ellen Richie, Pamela G. Robey, Marcello Rota, Jeffrey W. Ruberti, Alan J. Russell, E. Helene Sage, Rajiv Saigal, W. Mark Saltzman, Athanassios Sambanis, Jochen Schacht, Lori A. Setton, Upma Sharma, Paul T. Sharpe, Jonathan M.W. Slack, Anthony J. Smith, Martha J. Somerman, Lin Song, Bernat Soria, Frank E. Stockdale, Lorenz Studer, Shuichi Takayama, Juan R. Tejedo, Vickery Trinkaus-Randall, Alan Trounson, Rocky S. Tuan, Gregory H. Underhill, Konrad Urbanek, Charles A. Vacanti, Joseph Vacanti, F. Jerry Volenec, Gordana Vunjak-Novakovic, Lars U. Wahlberg, Derrick C. Wan, George M. Whitesides, Jeffrey A. Whitsett, James W. Wilson, Stefan Worgall, Mark E.K. Wong, Nicholas A. Wright, Ioannis V. Yannas, Ji-Won Yoon, Simon Young, Hai Zhang, Wenjie Zhang, Beth A. Zielinski, James D. Zieske, Wolfram-Hubertus Zimmermann, and Laurie Zoloth

Published
2007

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