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Your search keyword '"Anna Stochel-Gaudyn"' showing total 2 results
Start Over Author "Anna Stochel-Gaudyn" Publisher elsevier
2 results on '"Anna Stochel-Gaudyn"'

1. Mn3+-saturated bovine lactoferrin as a new complex with potential prebiotic activities for dysbiosis treatment and prevention – On the synthesis, chemical characterization and origin of biological activity

Author

Klaudyna Śpiewak, Grzegorz Majka, Magdalena Pilarczyk- Żurek, Paweł M. Nowak, Michał Woźniakiewicz, Piotr Pietrzyk, Tomasz Korzeniak, Anna Stochel-Gaudyn, Krzysztof Fyderek, Magdalena Strus, and Małgorzata Brindell

Subjects
Lactobacillus, Dysbiosis, Manganese, Lactoferrin, Prebiotic, Probiotic, Nutrition. Foods and food supply, TX341-641
Abstract

A new bioactive compound, Mn3+-saturated bovine lactoferrin (Mn2-bLf) was obtained. It was stable under physiological conditions (pH ≈ 7.5) although gradually releases Mn2+ ions under the simulated intestinal conditions (pH ≈ 6.5). This feature might be utilized for controlled delivery of Mn2+ ions to biological targets, among others to the probiotic strains of lactic acid bacteria whose growth is manganese-dependent. The Mn3+ modified bLf stimulates the growth of standard Lactobacillus plantarum and Lactobacillus rhamnosus, as well as the strains isolated from commercially available probiotic preparations, while the naturally occurring Fe-free and Fe-saturated forms of this protein are inactive. The uptake of manganese by Lactobacilli from Mn2-bLf added to culture supernatant was confirmed. Mn2-bLf was non-cytotoxic for Caco-2, CT-26 and HT-29 intestinal epithelial cells even up to 10 mg/ml concentration. Mn2-bLf due to stimulation of the growth of Lactobacilli and lack of toxicity, can be considered as an innovative ingredient of the prebiotic composition.

Published
2017
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2. Mn3+-saturated bovine lactoferrin as a new complex with potential prebiotic activities for dysbiosis treatment and prevention – On the synthesis, chemical characterization and origin of biological activity

Author

Grzegorz Majka, Anna Stochel-Gaudyn, Piotr Pietrzyk, Magdalena Pilarczyk Żurek, Tomasz Korzeniak, Krzysztof Fyderek, Paweł Mateusz Nowak, Michał Woźniakiewicz, Magdalena Strus, Klaudyna Śpiewak, and Małgorzata Brindell

Subjects
0301 basic medicine, medicine.medical_treatment, 030106 microbiology, Medicine (miscellaneous), Prebiotic, Biology, Probiotic, law.invention, 03 medical and health sciences, chemistry.chemical_compound, Lactobacillus rhamnosus, law, medicine, TX341-641, Manganese, Nutrition and Dietetics, Nutrition. Foods and food supply, food and beverages, Biological activity, biology.organism_classification, Bioactive compound, Lactic acid, Lactobacillus, Lactoferrin, 030104 developmental biology, Biochemistry, chemistry, Dysbiosis, Lactobacillus plantarum, Bacteria, Food Science
Abstract

A new bioactive compound, Mn3+-saturated bovine lactoferrin (Mn2-bLf) was obtained. It was stable under physiological conditions (pH ≈ 7.5) although gradually releases Mn2+ ions under the simulated intestinal conditions (pH ≈ 6.5). This feature might be utilized for controlled delivery of Mn2+ ions to biological targets, among others to the probiotic strains of lactic acid bacteria whose growth is manganese-dependent. The Mn3+ modified bLf stimulates the growth of standard Lactobacillus plantarum and Lactobacillus rhamnosus, as well as the strains isolated from commercially available probiotic preparations, while the naturally occurring Fe-free and Fe-saturated forms of this protein are inactive. The uptake of manganese by Lactobacilli from Mn2-bLf added to culture supernatant was confirmed. Mn2-bLf was non-cytotoxic for Caco-2, CT-26 and HT-29 intestinal epithelial cells even up to 10 mg/ml concentration. Mn2-bLf due to stimulation of the growth of Lactobacilli and lack of toxicity, can be considered as an innovative ingredient of the prebiotic composition.

Published
2017

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