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17 results on '"Alejandra de Moreno"'

1. Oral administration of milk fermented by Lactobacillus casei CRL431 was able to decrease metastasis from breast cancer in a murine model by modulating immune response locally in the lungs

Author

Virginia Emilce Mendez Utz, Gabriela Perdigón, and Alejandra de Moreno de LeBlanc

Subjects
Probiotic, Lung metastasis, Breast cancer, Immune response, Nutrition. Foods and food supply, TX341-641
Abstract

The host immune system is an important factor to combat metastasis. In this work, it was evaluated the immunomodulation exerted by milk fermented with the probiotic strain Lactobacillus casei CRL431 (PFM) when was administered to mice in the metastatic stage of breast cancer. Mice received PFM were compared to animals given milk. PFM administration diminished metastasis in the lungs and increased the survival of the animals. Systemically, PFM administration decreased pro-inflammatory cytokines and locally in the lungs (metastatic organs) decreased F4/80+ cells, principally IL-10/F4/80+ cells. The highest percentages for CD4+ and CD4+CD8+ cells were observed in PFM group. Finally, immune cells from lungs of mice given PFM showed lower production of most cytokines evaluated when they were re-stimulated in vitro with tumour cells. The results obtained suggest that modulation of immune cells in the lungs by PFM could be a strategy to fight against tumour cells in the metastatic sites.

Published
2019
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2. Tropical fruit by-products water extracts as sources of soluble fibres and phenolic compounds with potential antioxidant, anti-inflammatory, and functional properties

Author

Marcela Albuquerque Cavalcanti de Albuquerque, Romina Levit, Carolina Beres, Raquel Bedani, Alejandra de Moreno de LeBlanc, Susana Marta Isay Saad, and Jean Guy LeBlanc

Subjects
Probiotic, Fruit by-products, Dietary fibre, Phenolic compounds, Anti-inflammatory effect, Folate, Nutrition. Foods and food supply, TX341-641
Abstract

Fibre content, phenolic content, antioxidant and anti-inflammatory activities were evaluated for water extracts of fruit by-products (passion fruit, orange, acerola, and mango). The impact of these extracts on microbial growth, folate production, and adhesion ability of Streptococcus thermophilus TH-4 and Lactobacillus rhamnosus LGG was investigated. Mango water extract (MWE) presented the highest phenolic content and antioxidant activity. Orange water extract (OWE) and MWE showed the best anti-inflammatory potential by decreasing the highest nitric oxide levels. When TH-4 and LGG were grown together, folate production was only stimulated by MWE. Passion fruit water extract and OWE increased the TH-4 adhesion whereas acerola water extracts and MWE improved LGG adhesion when strains were used individually. These results showed that fruit by-product water extracts (FWE), especially from mango, presented potential beneficial biological and functional properties. These FWE could be used to develop new functional antioxidant foods and natural pharmaceutical ingredients.

Published
2019
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3. Evaluation of the bioavailability and intestinal effects of milk fermented by folate producing lactic acid bacteria in a depletion/repletion mice model

Author

Ana Clara C. Cucick, Katia Gianni, Svetoslav D. Todorov, Alejandra de Moreno de LeBlanc, JeanGuy LeBlanc, and Bernadette D.G.M. Franco

Subjects
Folate, Vitamin deficiency, Lactic acid bacteria, Bioavailability, Fermented milk, Nutrition. Foods and food supply, TX341-641
Abstract

This study aimed to evaluate the bioavailability and effects on the intestinal mucosa of a bioenriched fermented milk (BFM) prepared with folate-producing lactic acid bacteria, using a depletion/repletion BALB/c mice model. Five Streptococcus thermophilus strains were combined with Lactobacillus plantarum 16cv and the combination that resulted in the best folate production was used for preparation of BFM. The folate content in BFM, prepared under controlled conditions (pH 6.0, 42 °C, 70 rpm, 24 h), was 321.1 ± 14.1 ng/mL. Results for mice fed with BFM were compared to those fed with other diets. The BFM group presented an increase in hemoglobin, hematocrit and red blood cells, and the villi height/crypt depth ratio was similar to that of animals receiving milk supplemented with commercial folic acid. The strains were sensitive to most tested antibiotics and lacked virulence genes, indicating that consumption of BFM may be a promising alternative to increase intake of folate.

Published
2020
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6. Bioactive compounds of fruit by-products as potential prebiotics

Author

Jean Guy LeBlanc, Alejandra de Moreno de LeBlanc, Bernadette Dora Gombossy de Melo Franco, Igor Ucella Dantas de Medeiros, Marcela Albuquerque Cavalcanti de Albuquerque, and Susana Marta Isay Saad

Subjects
biology, Animal feed, Prebiotic, medicine.medical_treatment, food and beverages, biology.organism_classification, Lactic acid, B vitamins, chemistry.chemical_compound, Nutrient, chemistry, medicine, Fermentation, Beneficial organism, Food science, Bacteria
Abstract

Fruit by-products are generated by the food industries and constitute an important environmental problem. Although these fruit residues are frequently treated as industrial waste and used mainly for animal feed, they can be good sources of nutrients and bioactive compounds. Among them, dietary fibers and phenolics are bioactive compounds that can stimulate the growth and activity (including the production of B vitamins) of beneficial microorganisms, especially lactic acid bacteria and other probiotics. Bioactive compounds have also been explored to improve the nutritional and functional properties of food products. Thus, these compounds from fruit by-products emerge as potential prebiotic ingredients. In addition to the influence on beneficial microorganisms, bioactive compounds from fruit by-products may act as natural antioxidants with an important role in preventing human health, especially in the gastrointestinal tract, from inflammatory conditions. This chapter discusses how fruit by-products can be used as prebiotics to stimulate the production of bioactive compounds by lactic acid bacteria in the gastrointestinal tract or as ingredients to promote health benefits caused by bacterial fermentation.

Published
2021
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7. List of contributors

Author

Rana Muhammad Aadil, Samuel Chetachukwu Adegoke, Aziz Ahmad, Talha Ahmad, Muneer Ahmad Magry, Waqar Ahmed, Elif Tuğçe Aksun Tümerkan, Katariina Ala-Rämi, Marcela Albuquerque Cavalcanti de Albuquerque, Tânia Gonçalves Albuquerque, Maria Alexandri, Estefanía Álvarez-Castillo, Rita Carneiro Alves, H.V. Annegowda, A. Ascenso, J. Fernando Ayala-Zavala, Blanca E. Barragán-Huerta, Barbara Ruivo Valio Barretti, Carlos Bengoechea, M. Bento, Rajeev Bhat, Brij Bhushan, Nilutpal Bhuyan, D. Blaise, Marianne Su-Ling Brooks, Augusta Caligiani, Rocio Campos-Vega, M. Carvalheiro, Carlos Pasqualin Cavalheiro, S.M. Ceballos-Duque, Saravanan Chakkaravarthi, Wee Sim Choo, Nabajit Dev Choudhury, Wei Chean Chuah, Ng Lee Chuen, Fook Yee Chye, A. Costa, Helena S. Costa, Adriano Gomes da Cruz, Maurício Costa Alves da Silva, Íris Braz da Silva Araújo, Julio Cesar de Carvalho, Igor Ucella Dantas de Medeiros, Alejandra de Moreno de LeBlanc, Simone Lorena Quitério de Souza, Gargi Dey, Rerisson do Nascimento Alves, Elisa Dufoo-Hurtado, Salma A. Enríquez-Valencia, A.C. Faria-Silva, Manuel Felix, Maximilian Fichtner, Irina Fierascu, Radu Claudiu Fierascu, Scott W. Fowler, Bernadette Dora Gombossy de Melo Franco, Maria Patricia Guerrero Garcia-Ortega, Mohd Sabri Mohd Ghazali, L.M. Gonçalves, Almudena González González, Gustavo A. González-Aguilar, Anil H. Gore, Luna Goswami, Athanasia M. Goula, Antonio Guerrero, Jonas Toledo Guimarães, Datta B. Gunjal, Paulina Gutiérrez-Macías, Muhamad Fairus Noor Hassim, Ana M. Herrero, B.K.K.K. Jinadasa, Rupam Kataki, Moazzam Rafiq Khan, Timo Kikas, Marcela Kloth, Govind B. Kolekar, Konstantina Kourmentza, Apostolis Koutinas, Melinda Krebsz, Tharaka Rama Krishna C. Doddapaneni, Sonia Kumar, Luiz Gustavo Lacerda, Jean Guy LeBlanc, Ulla Lehtinen, Giulia Leni, Boon Fung Leong, Jade M. Long, Christelle Lopez, Leticia X. López-Martínez, Ivan Luzardo-Ocampo, Gabriela A. Macedo, Sergi Maicas, Sofia Maina, Pulak Majumder, Ma. Elena Maldonado-Celis, M. Marques, J. Marto, José Juan Mateo, Manickam Minakshi, Vicente A. Mirón-Mérida, Anand Mohan, Antonio Moreda-Piñeiro, Miriane Moreira Fernandes Santos, Vaibhav M. Naik, Sapna A. Narula, Rumi Narzari, Arunima Nayak, Mehdi Nikoo, Omkar S. Nille, Patrícia Nunes, M. Beatriz P.P. Oliveira, B. Dave Oomah, A. Paiva, Sandeep K. Panda, Harris Papapostolou, Tibor Pasinszki, Akshay S. Patil, Fábio Anderson Pereira Da Silva, Chanathip Pharino, Tatiana Colombo Pimentel, Gustavo Luis de Paiva Anciens Ramos, H.M. Ribeiro, C. Odín Rodríguez-Nava, Claudia Ruiz-Capillas, Susana Marta Isay Saad, Niharendu Saha, Amy Yi Hsan Saik, Ruprekha Saikia, Ádina L. Santana, S. Savitha, Philip A. Schneider, Dibyakanta Seth, Stefano Sforza, Muhammad Asim Shabbir, Elwira Sieniawska, Mafalda Alexandra Silva, Vida Šimat, P. Simões, S. Simões, Carlos Ricardo Soccol, Alessandra Cristine Novak Sydney, Eduardo Bittencourt Sydney, Reza Tahergorabi, Maria Tsiviki, Erminta Tsouko, K. Velmourougane, Simone Maria Ribas Vendramel, Ravindra D. Waghmare, V.N. Waghmare, Santad Wichienchot, and Adenise Lorenci Woiciechowski

Published
2021
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8. Probiotics in Cancer Prevention

Author

de LeBlanc, Alejandra de Moreno, primary, Bibas Bonet, María Eugenia, additional, LeBlanc, Jean Guy, additional, Sesma, Fernando, additional, and Perdigón, Gabriela, additional

Published
2010
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9. Oral administration of milk fermented by Lactobacillus casei CRL431 was able to decrease metastasis from breast cancer in a murine model by modulating immune response locally in the lungs

Author

Alejandra de Moreno de LeBlanc, Virginia Emilce Mendez Utz, and Gabriela Perdigón

Subjects
0301 basic medicine, Lactobacillus casei, Otras Ciencias Biológicas, Medicine (miscellaneous), Probiotic, law.invention, Metastasis, Ciencias Biológicas, purl.org/becyt/ford/1 [https], 03 medical and health sciences, 0404 agricultural biotechnology, Breast cancer, Immune system, Oral administration, law, BREAST CANCER, IMMUNE RESPONSE, medicine, TX341-641, Immune response, purl.org/becyt/ford/1.6 [https], 030109 nutrition & dietetics, Nutrition and Dietetics, biology, business.industry, Nutrition. Foods and food supply, PROBIOTIC, 04 agricultural and veterinary sciences, medicine.disease, biology.organism_classification, 040401 food science, In vitro, Lung metastasis, Cancer research, LUNG METASTASIS, business, CIENCIAS NATURALES Y EXACTAS, CD8, Food Science
Abstract

The host immune system is an important factor to combat metastasis. In this work, it was evaluated the immunomodulation exerted by milk fermented with the probiotic strain Lactobacillus casei CRL431 (PFM) when was administered to mice in the metastatic stage of breast cancer. Mice received PFM were compared to animals given milk. PFM administration diminished metastasis in the lungs and increased the survival of the animals. Systemically, PFM administration decreased pro-inflammatory cytokines and locally in the lungs (metastatic organs) decreased F4/80+ cells, principally IL-10/F4/80+ cells. The highest percentages for CD4+ and CD4+CD8+ cells were observed in PFM group. Finally, immune cells from lungs of mice given PFM showed lower production of most cytokines evaluated when they were re-stimulated in vitro with tumour cells. The results obtained suggest that modulation of immune cells in the lungs by PFM could be a strategy to fight against tumour cells in the metastatic sites. Fil: Méndez Utz, Virginia Emilce. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: Perdigon, Gabriela del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología. Cátedra de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina

Published
2019

10. Functional Food Biotechnology

Author

Anderson Miyoshi, Jean Guy LeBlanc, Tessalia Diniz Luerce, Alejandra de Moreno de LeBlanc, and Vasco Azevedo

Subjects
0301 basic medicine, business.industry, Genetically engineered, Microorganism, 030106 microbiology, food and beverages, Biology, Health benefits, biology.organism_classification, Lactic acid, Biotechnology, law.invention, 03 medical and health sciences, chemistry.chemical_compound, Probiotic, 030104 developmental biology, Nutraceutical, chemistry, Functional food, law, business, Bacteria
Abstract

The fact that certain foods can exert beneficial effects beyond their intrinsic nutritional values has led to the development of functional foods. The increase in nutraceutical content to obtain functional foods through the use of lactic acid bacteria (LAB) can be done by the appropriate selection of strains. However, genetic engineering of LAB allows the creation of microorganisms that are more efficient in producing nutraceuticals in sufficient quantities to exert biological effects. Another mechanism by which LAB can be used to produce functional foods is their use as probiotic microorganisms, when live than administered in adequate amounts can confer a health benefit on the host. In this chapter, the use of native and genetically engineered LAB as nutraceutical factories or probiotic microorganisms to obtain functional foods will be discussed.

Published
2018
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11. List of Contributors

Author

Irene Ai-Ling García Yu, Farhad Alavi, Laila AL-Ayadhi, Marzia Albenzio, Maria J.M. Alférez, Arturo Anadón, Irma Ares, Giovana V. Barancelli, Dale E. Bauman, Kathryn L. Beck, John Birch, Phil Bremer, Keegan Burrow, Kathleen L. Caldwell, Felipe C. Cardoso, Domenico Carminati, Alan Carne, Mariangela Caroprese, Jade Chia, Philip D. Chilibeck, Jane Coad, Robert J. Collier, Giuseppe Conte, Carlos H. Corassin, Marine S. Da Silva, Li Day, Gilberto V. de Melo Pereira, Alejandra de Moreno de LeBlanc, Carlos Augusto F. de Oliveira, Javier Diaz-Castro, Whitney Duff, Alaa El-Din A. Bekhit, Zahra Emam-Djomeh, Maurício J. Fernandes, Carolina M. Galdeano, Rohin Galhotra, Reza Ghiasvand, Bruna L. Gonçalves, Dost M. Halepoto, Kasper Hettinga, Furhan Iqbal, Robert L. Jones, Caroline C. Kalebich, Shrikant D. Kalyankar, Halit Kanca, Rajeev Kapila, Suman Kapila, Humera Khatoon, Chaitali C. Khedkar, Chandraprakash D. Khedkar, Saija Kontulainen, Naresh Kumar, Jean Guy LeBlanc, Sarah H.I. Lee, Romina Levit, Inmaculada López-Aliaga, Amir Makhmudov, María R. Martínez-Larrañaga, María A. Martínez, Sue Mason, Michelle McConnell, Marcello Mele, Maryam Miraghajani, Eliran Mizelman, Mehdi Mohammadian, Jorge Moreno-Fernandez, James D. Morton, Rahela Najam, Ivanna N. Nuñez, Indrawati Oey, Sebnem Ozturkoglu-Budak, Maria G.B. Pagnoncelli, Alyssa M. Parker, Ami R. Patel, Gabriela Perdigón, Paula C. Pereira, Anna N. Polito, Makan Pourmasoumi, Midathala Raghavendra, Ali Rashidinejad, José I. Recio-Rodríguez, Iwona Rudkowska, Maryam Salami, Linda Samuelsson, Natalia Sánchez-Aguadero, Antonella Santillo, Graciela Savoy de Giori, Andrea Serra, Yasser Shahbazi, Hari R. Singal, Carlos R. Soccol, Valcineide O.A. Tanobe, Flavio Tidona, Jayanti Tokas, Nazli Turkmen, Hein van Valenberg, Kathryn A. Vance, Filipa Vicente, Rishika Vij, Ye Wang, Ronald Ross Watson, Yao Xiao, and Wayne Young

Published
2018
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12. List of Contributors

Author

Hasan Afzaal, Amjad Ali, Zeeshan Ali, Jaspreet S. Arora, Kulanthaiyesu Arunkumar, Marcela S.P. Azevedo, Vasco Azevedo, Mustafeez M. Babar, Debmalya Barh, Kartikay Bisen, Isabel S. Carvalho, Rekha Chawla, Karthik Chinnannan, Ana Coelho, Sintia S. De Almeida, Siomar De Castro Soares, Alejandra de Moreno de LeBlanc, Cassiana S. De Sousa, Rajesh K. Dubey, Atul Grover, Alvina Gul, Sanjay M. Gupta, Syed S. Hassan, Yousef I. Hassan, Shahid Iqbal, Rija Irfan, Jyoti S. Jadaun, Anu Kalia, Chetan Keswani, Faria Khan, Md Gulam M. Khan, Surender Khatodia, Sathiya Kumar, Sekar Kumaran, Jean Guy LeBlanc, Tessalia D. Luerce, Lekha C. Meher, Mohammad F. Miah, Zujaja T. Misbah, Bhawana Mishra, Anderson Miyoshi, Chandra S. Mukhopadhyay, Anjana Munshi, Malik G. Mustafa, Lokesh K. Narnoliya, Mohammed Nasim, Duy Nguyen, Ricardo Nunes, Indra A. Padikasan, Sajida Parveen, Vikas Y. Patade, S.M. Paul Khurana, Anne C. Pinto, Venkata R. Pothineni, Raja Rathinam, Ratul M. Ram, Clarissa S. Rocha, Pavel Samuleev, Neelam S. Sangwan, Rajender S. Sangwan, Ramaraj Sathasivam, Kanwal Shaheen, Hemaiswarya Shanmugam, Manju Sharma, S.P. Sharma, Vandana Sharma, Wanderson M. Silva, Harikesh B. Singh, Surya P. Singh, Govindaraju Subramaniyan, Natesan Sudhakar, Tehreem Tanveer, Ruchi Tripathi, Sandhya Tripathi, Daria Trofimova, Kinza Waqar, Muhammad A. Zahid, Najam-us-Sahar S. Zaidi, and Ting Zhou

Published
2018
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13. List of Contributors

Author

Sandra Abreu, Ceren Akal, Farhad Alavi, Wataru Aoi, Monowar Aziz, Siddhi M. Bagwe, Jocelyne R. Benatar, Helle Kirstine Mørup Bergholdt, Sukhwinder K. Bhullar, Claire Bourlieu, Wolfram M. Brück, Harpal S. Buttar, Peter Clifton, Lucia H. da Silva Miglioranza, Ilse De Bourdeaudhuij, Alejandra de Moreno de LeBlanc, Sara De Pelsmaeker, Hans De Steur, Ronald P. de Vries, Eda Deci, Isaias Dichi, Christina Ellervik, Zahra Emam-Djomeh, Javier Fontecha, Claudio Galli, Daniel Garrido, Xavier Gellynck, Christiane L. Girard, Benoît Graulet, Giuseppe Grosso, Laura W. Hansen, Alfheidur Haraldsdottir, Lars I. Hellgren, Michael Horowitz, Ying-Hsin Hsieh, Masayo Iwasa, Manuela Juárez, Ana Kapaj, Rajeev Kapila, Suman Kapila, Ginpreet Kaur, Naresh Kumar, Sofie Lagast, Manon Lecomte, Alina Li, Jie Li, Simin Liu, Marcell A.B. Lovozoy, Daniel R. Machin, Virginia E. Méndez Utz, Marie-Caroline Michalski, Mehdi Mohammadian, Luís A. Nero, Paul Nestel, Tirang R. Neyestani, Bahareh Nikooyeh, Pernille Nordby, Børge Grønne Nordestgaard, Sebnem Ozturkoglu-Budak, Gabriela Perdigón, Luana M. Perin, Jose M. Prince, Midathala Raghavendra, Christopher K. Rayner, Patrizia Risé, Maryam Salami, Bruna M. Scavuzzi, Joachim Jietse Schouteten, Valdemiro C. Sgarbieri, Rohit Sharma, Andréa N.C. Simão, Hari R. Singal, Yan Song, Irshad M. Sulaiman, Hirofumi Tanaka, Pamela Thomson, Jayanti Tokas, Johanna E. Torfadottir, Nazli Turkmen, Anette Varbo, Ping Wang, Linda E. Watson, Andrea S. Wiley, and Tongzhi Wu

Published
2017
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14. Contributors

Author

Amir Hossein Abdolghaffari, Mohammad Abdollahi, Hamid Ahanchian, Farah N. Ahmad, Fariborz Akbarzadeh, Giovanni Alighieri, Amir Amini, Arturo Anadón, Caterina Anania, Bruno Annibale, Mattia Pia Arena, Angela Arena, Irma Arés, Anthoula A. Argyri, Belma Aslim, Selcen Babaoğlu Aydaş, Amirreza Azimi, Antonio O. Ballesteros, Joana Barbosa, Parvin Bastani, Raquel Bedani, Pasqua Betta, Mohammad-Hossein Biglu, Sandra Borges, C. Bucci, Flávia C.A. Buriti, R.M. Camacho-Ruiz, Vittorio Capozzi, Piero Catenazzi, Camilla Celani, Saikiran Chaluvadi, Claude P. Champagne, Claudio Chiesa, Eva H. Clark, Robert J. Collier, Jacopo Colombo, Alejandra de Moreno de LeBlanc, Elisa Carvalho de Morais, M. Dekker, D. Di Venere, Lorenzo Drago, Edward R. Farnworth, Wojciech Feleszko, Lucia Fernandez-Arrojo, J. Fernández-López, Alberto Finamore, Daniela Fiocco, F.J. Gatesoupe, Farnaz Ghasemi-Niri, Valentina Giacchi, Babak Golkhalkhali, A. Gomez-Zavaglia, Maziar Gooshe, Zuhal Gundogdu, Irene Hanning, Seyed Mohammad Bagher Hashemi, Rajkumar Hemalatha, Aziz Homayouni, Arland T. Hotchkiss, P. Iovino, Susana Marta Isay Saad, Mohammad Asghari Jafarabadi, Seyed Ali Jafari, Rosita Jamaluddin, Ji-Kang Jeong, Felicita Jirillo, Emilio Jirillo, Rheinallt M. Jones, Baljinder Kaur, Gaganjot Kaur, Ata K. Keshtiban, Mohammad Khalili, Leyla Khalili, Leila Khalili, Nina Kirmiz, Manoj Kumar, Edith Lahner, P. Lavermicocca, Jean Guy LeBlanc, Eleni Likotrafiti, Ying-Jye Lim, Jody Lingbeck, Paloma López, Mª Luz Mohedano, Thea Magrone, Reza Mahdavi, Davood Maleki, Fatemeh Mallah, Shreesh J. Marathe, Francesco Marotta, María Aránzazu Martínez, O. Martinez-Augustin, María Rosa Martínez-Larrañaga, Elnaz Vaghef Mehrabany, David A. Mills, Mitchel Graham Stover, P. Mobili, Diya Mohammad, Sakineh Mohammad-Alizadeh-Charandabi, S. Mohd Redzwan, Vicente Monedero, Jose M. Moreno Villares, L. Moreno-Vilet, Lee E. Morrow, Masaaki Motoori, Jayasimha N. Murthy, Montserrat Nácher-Vázquez, Ravinder Nagpal, Dennis Sandris Nielsen, Hossein Nikniaz, Leila Nikniaz, Zeinab Nikniaz, Sara Notararigo, Vânia dos Santos Nunes, Rok Orel, Ali Osman, Arthur C. Ouwehand, Lucia Pacifico, Efstathios Z. Panagou, Kun-Young Park, Laleh Payahoo, Ilaria Peluso, J.A. Pérez-Alvarez, Adrian Pérez-Ramos, Francisco J. Plou, Seyedeh Leila Poorbaghi, D.P. Portales-Pérez, Eamonn M.M. Quigley, Fatemeh Ranjbar, Lea Vodušek Reberšak, Jonathan Rhoades, Steven C. Ricke, Barbara Rodriguez-Colinas, Jesús Rodríguez-Díaz, N. Romano, Pasquale Russo, F. Russo, Marek Ruszczyński, Susana M.I. Saad, F. Sánchez de Medina, A. Santonicola, M.E. Sayas-Barberá, Pietro Sciacca, Antonio Scorrano, E. Sendra, Masood Sepehrimanesh, Mauro Serafini, Lynette Pei-Chi Shek, Behjat Shokrvash, A. Sisto, Katia Sivieri, Maria Lena Skalkam, Shu-E Soh, Giuseppe Spano, Keijiro Sugimura, Koji Tanaka, Chrysoula C. Tassou, Paula Teixeira, Julia Tennilä, Marco Toscano, Alok S. Tripathi, E. Tymczyszyn, F. Valerio, Gabriella van Zanten, Paulo José Fortes Villas Boas, Patrick Alexander Wachholz, Ronald Ross Watson, Maria Wiese, Hariom Yadav, Kit L. Yam, Masahiko Yano, Hongliang Zeng, Yi Zhang, Baodong Zheng, Somayeh Ziyadi, and Antonio Alberto Zuppa

Published
2016
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15. Probiotics in Inflammatory Bowel Diseases and Cancer Prevention

Author

Alejandra de Moreno de LeBlanc and Jean Guy LeBlanc

Subjects
Cancer prevention, biology, Cancer, Inflammation, Gut flora, medicine.disease_cause, biology.organism_classification, medicine.disease, law.invention, Clinical trial, Probiotic, Immune system, law, Immunology, medicine, medicine.symptom, Oxidative stress
Abstract

Several studies have shown that specific probiotic strains are able to prevent the development of some diseases such as inflammatory bowel diseases (IBD) and certain types of cancer. Some of the proposed mechanisms of action that account for their beneficial effects include changes in the gut microbiota, stabilization of the intestine’s permeability barrier, regulation of the host immune responses, and reduction of the oxidative stress due to their antioxidant enzyme production. This chapter will examine some examples of studies using animal models and human clinical trials where probiotics were shown to be effective in the prevention or treatment of IBD and intestinal and nonintestinal cancers, and describe the current knowledge of their mechanisms of action. Probiotics could potentiate conventional treatments and reduce undesirable side effects and thus improve the general well-being of subjects that suffer from these diseases.

Published
2016
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16. Evaluation of a Streptococcus thermophilus strain with innate anti-inflammatory properties as a vehicle for IL-10 cDNA delivery in an acute colitis model

Author

Jean Guy LeBlanc, Anderson Miyoshi, Silvina del Carmen, Alejandra de Moreno de LeBlanc, and Vasco Azevedo

Subjects
Streptococcus thermophilus, DNA, Complementary, medicine.drug_class, Immunology, Anti-Inflammatory Agents, medicine.disease_cause, Biochemistry, Anti-inflammatory, Microbiology, Mice, Plasmid, Drug Delivery Systems, In vivo, Complementary DNA, medicine, Immunology and Allergy, Animals, Humans, DNA DELIVERY, Molecular Biology, biology, Strain (chemistry), Streptococcus, Body Weight, INFLAMMATORY BOWEL DISEASE, Hematology, ANTI INFLAMMATORY, biology.organism_classification, Colitis, INTERLEUKIN-10, Body Fluids, Interleukin-10, Intestines, Interleukin 10, Disease Models, Animal, Liver, STREPTOCOCCUS THERMOPHILS, Caco-2 Cells
Abstract

The aim of this work was to develop a Streptococcus (S.) thermophilus strain with improved anti-inflammatory properties due to the incorporation of the therapeutic cDNA delivery plasmid pValac::il-10. To achieve this purpose, cells of S. thermophilus CRL807, previously selected as being an important anti-inflammatory strain, were electroporated with pValac::il-10 plasmid. In order to confirm the functionality of the developed strain, it was co-cultured with human epithelial cells Caco-2 and the production of IL-10 was evaluated by ELISA. Bacterial suspensions of S. thermophilus CRL807 containing pValac::il-10 plasmid or of the wild-type (WT) strain were administered in vivo using a murine model of intestinal inflammation. The animals treated with S. thermophilus CRL807 pValac::il-10 showed a lower body weight loss, microbial translocation to liver and damage scores in their intestines at macroscopical and microscopic levels. Furthermore, a significant increase was observed in the concentration of IL-10 in the intestinal contents of these mice compared to the rest of the experimental groups, accompanied by decreased levels of pro-inflammatory cytokines. The insertion of the therapeutic pValac::il-10 plasmid increased the intrinsic anti-inflammatory activity (synergetic effect) of S. thermophilus CRL807 which could be included in novel treatment protocols for inflammatory bowel diseases. Fil: del Carmen, Silvina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina Fil: Miyoshi, Anderson. Universidade Federal do Minas Gerais; Brasil Fil: Azevedo, Vasco. Universidade Federal do Minas Gerais; Brasil Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina

Published
2015

17. Contributors

Author

Giovanni Alighieri, Arturo Anadón, María Eugenia Bibas Bonet, Oscar Brunser, Alicja Budak, Kirsten Buddendick, Britta Bunselmeyer, Virginia Caballero, Hong Cao, Christine M. Carey, Victor Castellano, Claude Champagne, Jian Jun Chen, Maria Carmen Collado, Mònica Comalada, José Eduardo de Aguilar-Nascimento, Guido de Marco, Alejandra de Moreno de LeBlanc, Michael de Vrese, Kelly Dowhower Karpa, Edward R. Farnworth, Wojciech Feleszko, Juana Fernández-López, Leo R. Fitzpatrick, Francesco Franceschi, Yoichi Fukushima, Julio Gálvez, Antonio Gasbarrini, Joel Gatesoupe, Philippe Gérard, Giovanni Gigante, Bianca Giupponi, Martin Gotteland, Miguel Gueimonde, Irene B. Hanning, Kazuhiro Hirayama, Sheng-He Huang, Eva Hurt, Joanna Jaworska, Ambrose Jong, Dowhower Karpa Kelly, Magdalena Kostrzynska, Federico Lara-Villaslada, Jean Guy LeBlanc, Jody M. Lingbeck, Ulrike Lodemann, Mirjam Looijer-van Langen, Sandra Macfarlane, Tomasz Mach, Karen Madsen, Maria Rosa Martínez-Larrañaga, Jose M. Moreno-Villares, Koji Nomoto, B. Offick, Mónica Olivares, Gareth C. Parkes, Gabriela Perdigón, José Angel Pérez-Alvarez, Antonio Marcos Pupin, Sylvie Rabot, Steven C. Ricke, Davide Roccarina, Ika Sai, Seppo Salminen, Silvia Salvatore, Arlette Santacruz, Yolanda Sanz, Estrella Sayas-Barberá, Antonio Scorrano, Esther Sendra Nadal, Fernando Sesma, Roy D. Sleator, Julie Smolyansky, Livia Trois, Yvan Vandenplas, Gigi Veereman-Wauters, Jordi Xaus, Antonio Alberto Zuppa, and Malgorzata Zwolińska-Wcislo

Published
2010
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