1. The effects of tumor-derived supernatants (TDS) on cancer cell progression: A review and update on carcinogenesis and immunotherapy.
- Author
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Ahmadpour S, Habibi MA, Ghazi FS, Molazadeh M, Pashaie MR, and Mohammadpour Y
- Subjects
- Humans, Tumor Microenvironment, Animals, Cytokines metabolism, Immunotherapy methods, Neoplasms immunology, Neoplasms therapy, Neoplasms pathology, Carcinogenesis immunology, Disease Progression
- Abstract
Tumors can produce bioactive substances called tumor-derived supernatants (TDS) that modify the immune response in the host body. This can result in immunosuppressive effects that promote the growth and spread of cancer. During tumorigenesis, the exudation of these substances can disrupt the function of immune sentinels in the host and reinforce the support for cancer cell growth. Tumor cells produce cytokines, growth factors, and proteins, which contribute to the progression of the tumor and the formation of premetastatic niches. By understanding how cancer cells influence the host immune system through the secretion of these factors, we can gain new insights into cancer diagnosis and therapy., Competing Interests: Declaration of competing interest The authors declare that they have no competing interests., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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