Search

Tumors can produce bioactive substances called tumor-derived supernatants (TDS) that modify the immune response in the host body. This can result in immunosuppressive effects that promote the growth and spread of cancer. During tumorigenesis, the exudation of these substances can disrupt the function of immune sentinels in the host and reinforce the support for cancer cell growth. Tumor cells produce cytokines, growth factors, and proteins, which contribute to the progression of the tumor and the formation of premetastatic niches. By understanding how cancer cells influence the host immune system through the secretion of these factors, we can gain new insights into cancer diagnosis and therapy., Competing Interests: Declaration of competing interest The authors declare that they have no competing interests., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Objectives: This systematic review presented the current status of literature on the outcomes resulted from sensory stimuli in critical care environments as well as the environmental interventions that can improve or impede the impact of such sensory stimuli., Methods: Articles found through a systematic search of PsycINFO, Web of Science, and PubMed databases, in combination with a hand search, were reviewed for eligibility by two independent coders. Reporting and quality appraisals were based on PRISMA and MMAT guidelines., Results: Out of 1118 articles found, and only 30 were eligible. Final articles were comprised of issues related to noise, lighting, and temperature. Identified sensory stimuli resulted in psychological and physiological outcomes among both patients and staff. Examples include impacts on stress, delirium, sleep disturbances, poor performance and communication. The environmental factors that influence sensory stimuli included layout, room size, artificial lighting, presence of windows and acoustical interventions., Conclusion: Literature on the impact of sensory stimuli on staff is scarce compared to patients. Studies on environmental interventions are inadequate and lack structure. The physical environment can impact the patient and staff outcome resulting from noise, lighting, and temperature. When applied strategically, sensory stimuli can result in positive outcomes among patients and staff., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Breast cancer deaths occur mainly because of poor diagnosis in early stages that lead to tumor metastasis in advanced stages. Developing a high-sensitive early-stage breast cancer diagnostic tool based on single photon emission computer tomography (SPECT) and positron emission tomography (PET) are urgent. There are several evidences to demonstrate the prominent roles of specific receptors overexpression in tumor initiation and progression of breast cancer. Targeting of specific receptor with radiolabeled biomolecule is a suitable tool for early diagnosis of breast cancer. In recent years, investigators have paid their attention in the development of peptide-based radiopharmaceuticals due to their favorable pharmacokinetics that offer diagnostic applications for breast cancer imaging. Various characterizing techniques permit the preparation of variety of peptides that allow efficiently labeling with clinically useful SPECT radionuclides such as 99m Tc, 123 I and 111 In without compromising biological properties. In this review, we focus on the recent developments in use of peptide-based SPECT radiopharmaceuticals for breast cancer targeting and imaging., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Chalcogenide glasses are significant materials for semiconducting and infrared imaging because of their infrared (IR) transparency. In the present study, Se-Ge-As based chalcogenide glasses with chemical composition of (Se 0.6 As 0.1 Ge 0.3 ) 100-x Sn x doped with different amounts of Sn were prepared by conventional melting-quenching method. Physical properties of glasses were investigated by studying density and molar volume. Based on differential scanning calorimetry (DSC) results and density measurements, the binary role of Sn was proved. Fourier transform infrared spectroscopy (FT-IR) study of the samples approved presence of impurities. Using the UV-Vis spectra, optical properties including Fermi energy level, direct and indirect optical band gap and Urbach energy were determined. The results showed a decrease in density of glasses with the increase of Sn from 2 to 6 mol%. Increasing Sn in the glassy microstructure of samples provides a semiconducting character to Se based chalcogenide glass by reducing the direct and indirect optical band gaps of glass samples from 1.29 to 1.15 (eV) and 1.16 to 1.01 (eV), respectively., (Copyright © 2018 Elsevier B.V. All rights reserved.)

A poly (vinyl chloride) (PVC) matrix membrane ion-selective electrode for silver (I) ion is fabricated based on modified polypyrrole - multiwalled carbon nanotubes composite with new lariat ether. This sensor has a Nernstian slope of 59.4±0.5mV/decade over a wide linear concentration range of 1.0×10(-7) to 1.0×10(-1)molL(-1) for silver (I) ion. It has a short response time of about 8.0s and can be used for at least 50days. The detection limit is 9.3×10(-8)molL(-1) for silver (I) ion, and the electrode was applicable in the wide pH range of 1.6 -7.7. The electrode shows good selectivity for silver ion against many cations such as Hg (II), which usually imposes serious interference in the determination of silver ion concentration. The use of multiwalled carbon nanotubes (MWCNTs) in a polymer matrix improves the linear range and sensitivity of the electrode. In addition by coating the solid contact with a layer of the polypyrrole (Ppy) before coating the membrane on it, not only did it reduce the drift in potential, but a shorter response time was also resulted. The proposed electrode was used as an indicator electrode for potentiometric titration of silver ions with chloride anions and in the titration of mixed halides. This electrode was successfully applied for the determination of silver ions in silver sulphadiazine as a burning cream., (© 2013.)