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1. Contributors

Author

Abdou, Nabih I., primary, Ahmad, Nazia, additional, Aliniazee, Muddassir, additional, Alvi, Sarah, additional, Amatniek, Joan, additional, Anderson, David E., additional, Aranoff, Gaya S., additional, Bachmann, Gloria, additional, Balaram, Sandhya K., additional, Barbieri, Elizabeth, additional, Bartlik, Barbara D., additional, Bassuk, Shari S., additional, Bateman, David, additional, Bauman, Kristy A., additional, Bell, Jennifer J., additional, Bilello, Kathryn, additional, Blasberg, Justin D., additional, Blumenthal, Roger S., additional, Bockow, Tamara, additional, Boyle, Karen Elizabeth, additional, Burnett, Arthur L., additional, Burrows, Lara J., additional, Byne, William, additional, Chapman, Kenneth R., additional, Chesney, Margaret A., additional, Chew, Debra, additional, Chung, Doreen E., additional, Chung, Pak H., additional, Chung, Wendy K., additional, Clark, Christine A., additional, Cutolo, Maurizio, additional, Davidson, Nancy E., additional, Deveci, Serkan, additional, Dobs, Adrian, additional, Doty, Nora J., additional, Dubeau, Catherine E., additional, El-maouche, Diala, additional, Feisullin, Karen, additional, Frey, Lauren, additional, Garvin, James H., additional, Gaynor, Katya, additional, Gearhart, Susan L., additional, Ghanem, Khalil G., additional, Glassberg, Marilyn K., additional, Golden, Sherita Hill, additional, Goldstein, Andrew T., additional, Goldstein, Marc, additional, Gottesman, Rebecca F., additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Han, Meilan K., additional, Harris, Mary L., additional, Hauser, W. Allen, additional, Hillis, Argye E., additional, Hodder, Sally L., additional, Holley, Aaron, additional, Jacobs, Diane, additional, Jan De Beur, Suzanne M., additional, Johnson, Paula A., additional, Kashyap, Sonya, additional, Kaufman, David M., additional, Kim, Howard H., additional, Kim, Matthew, additional, Kobzik, Lester, additional, Kolzet, Julie A., additional, Koteish, Ayman, additional, Krok, Karen, additional, Lahita, Robert G., additional, Lanatra, Nicole, additional, Laskin, Carl A., additional, Lazarus, George M., additional, Lee, Linda A., additional, Legato, Marianne J., additional, Leghe, Jaswinder K., additional, Lewin, Sharon, additional, Lim, Robert H., additional, Manson, Joann E., additional, Mccarthy, Margaret, additional, Mehrani, Taraneh, additional, Metzl, Jordan D., additional, Moores, Lisa, additional, Moseley, Kendall F., additional, Mulhall, John P., additional, Mullin, Gerald, additional, Munsell, Melissa, additional, Murin, Susan, additional, Nagy, Christian D., additional, Omene, Coral, additional, Parkman, Henry P., additional, Parveen, Tahmina, additional, Petri, Michelle, additional, Pickett-Blakely, Octavia, additional, Polsky, Bruce, additional, Powell, Charles A., additional, Rendel, Michael, additional, Rider, Virginia, additional, Romanzi, Lauri J., additional, Rompalo, Anne M., additional, Rosen, Tove S., additional, Sanfey, Hilary, additional, Sano, Mary, additional, Schlegel, Peter N., additional, Seeman, Mary V., additional, Shafazand, Shirin, additional, Sharma, Kavita, additional, Sheares, Beverley J., additional, Shure, Deborah, additional, Sonenshine, Marc, additional, Sordillo, Emilia Mia, additional, Sorra, Karin, additional, Spitzer, Karen A., additional, Swaminathan, Shobha, additional, Te, Alexis E., additional, Tiersten, Amy, additional, Toonkel, Rebecca L., additional, Tyagi, Renuka, additional, Walker, Sara E., additional, and Westhoff, Carolyn, additional

Published
2010
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2. Female Sexual Health

Author

Bartlik, Barbara D., primary, Kolzet, Julie A., additional, Ahmad, Nazia, additional, Parveen, Tahmina, additional, and Alvi, Sarah, additional

Published
2010
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3. 1,3,4-oxadiazole conjugates of capsaicin as potent NorA efflux pump inhibitors of Staphylococcus aureus.

Author

Naaz F, Khan A, Kumari A, Ali I, Ahmad F, Ahmad Lone B, Ahmad N, Ali Khan I, Rajput VS, Grover A, and Shafi S

Subjects
Anti-Bacterial Agents chemical synthesis, Anti-Bacterial Agents metabolism, Anti-Bacterial Agents pharmacology, Bacterial Proteins metabolism, Binding Sites, Cell Line, Tumor, Cell Survival drug effects, Ciprofloxacin pharmacology, Drug Resistance, Multiple, Bacterial drug effects, Humans, Kinetics, Microbial Sensitivity Tests, Molecular Docking Simulation, Multidrug Resistance-Associated Proteins metabolism, Staphylococcus aureus drug effects, Structure-Activity Relationship, Anti-Bacterial Agents chemistry, Bacterial Proteins antagonists & inhibitors, Capsaicin chemistry, Multidrug Resistance-Associated Proteins antagonists & inhibitors, Oxadiazoles chemistry, Staphylococcus aureus metabolism
Abstract

NorA efflux pump pertaining to the major facilitator superfamily (MFS) is known to play a key role in antibiotic and biocide resistance in Staphylococcus aureus (S. aureus). It accounts for the extrusion of antibiotics like fluoroquinolones (e.g. ciprofloxacin). Several compounds including synthetic and natural products have been identified as potential NorA efflux pump inhibitors (EPIs) and found to restore the antibacterial activity of antibiotics. However, none of the reported EPIs have reached to clinical approval probably due to their high toxicity profiles. Considering the NorA efflux pump inhibitory potential of capsaicin, a series of capsaicin-based 1,3,4 oxadiazole conjugates were prepared and evaluated for ciprofloxacin activity potentiating effect. Among the new capsaicinoids tested, 17i displayed a minimum effective concentration (MEC) of 12.5 µg/mL against NorA overexpressing S. aureus strain (SA1199B), whereas capsaicin showed MEC of 50 µg/mL. The kill kinetics curve for the combination showed that ciprofloxacin at a sub-inhibitory concentration (0.25 × MIC) was equipotent in effect, to its MIC. 17i has significantly decreased the ethidium bromide efflux confirming NorA inhibition as the mode of action. Mutation prevention concentration of the ciprofloxacin was reduced in combination with 17i.In silico studies revealed the binding efficiency and binding affinity of 17i with NorA. This compound may serve as a template for the further drug discovery., (Copyright © 2021. Published by Elsevier Inc.)

Published
2021
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4. Biomedical applications of environmental friendly poly-hydroxyalkanoates.

Author

Ansari S, Sami N, Yasin D, Ahmad N, and Fatma T

Subjects
Animals, Biodegradation, Environmental, Humans, Medical Waste, Medical Waste Disposal, Biocompatible Materials chemistry, COVID-19, Polyhydroxyalkanoates chemistry, SARS-CoV-2
Abstract

Biological polyesters of hydroxyacids are known as polyhydroxyalkanoates (PHA). They have proved to be an alternative, environmentally friendly and attractive candidate for the replacement of petroleum-based plastics in many applications. Many bacteria synthesize these compounds as an intracellular carbon and energy compound usually under unbalanced growth conditions. Biodegradability and biocompatibility of different PHA has been studied in cell culture systems or in an animal host during the last few decades. Such investigations have proposed that PHA can be used as biomaterials for applications in conventional medical devices such as sutures, patches, meshes, implants, and tissue engineering scaffolds as well. Moreover, findings related to encapsulation capability and degradation kinetics of some PHA polymers has paved their way for development of controlled drug delivery systems. The present review discusses about bio-plastics, their characteristics, examines the key findings and recent advances highlighting the usage of bio-plastics in different medical devices. The patents concerning to PHA application in biomedical field have been also enlisted that will provide a brief overview of the status of research in bio-plastic. This would help medical researchers and practitioners to replace the synthetic plastics aids that are currently being used. Simultaneously, it could also prove to be a strong step in reducing the plastic pollution that surged abruptly due to the COVID-19 medical waste., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Published
2021
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