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Publisher Summary This chapter discusses the potentialities of neurophysiology in study and cure of mental disorder in epilepsy. The therapeutic value of the electrical stimulations is a result of the forcing out of the newly formed pathological dominant. The electrical stimulations exert their therapeutic effects either as artificial clinical signs usually related to the system of positive reinforcement or as subclinical—mainly electrical—signs of epileptogenesis suppression. The dynamics of different mental parameters at different periods of the epileptic process aids understanding of the mechanism of hypermnesias of the hallucination type, forcible memories from the past experience, and other psychopathological symptoms associated with partial epileptic seizures. The epileptogenic focus induces hyperactivity of separate functional systems, and this leads to mental disturbances ranging up to epileptic psychoses. The epileptogenic focus exerts powerful effects upon relatively intact cerebral structures and distorts the coordination of direct and indirect effects. This disrupts the selective distribution of effects and the process of recruitment, that is, the unification of systems into a systemic response appropriate for biological survival.