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3. Preface

Author

Ram K. Gupta, Tuan Anh Nguyen, Muhammad Bilal, and Mazaher Ahmadi

Published
2023
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4. Preface

Author

Gautam M. Patel, Nisar Ali, Muhammad Bilal, Tuan Anh Nguyen, Adnan Khan, and Ram K. Gupta

Published
2023
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5. List of contributors

Author

Srinivasan Alagappan, Kevin V. Alex, S. Angitha, Elsa Antunes, Rajendran Suresh Babu, Daneshwaran Balaji, Payel Bandyopadhyay, Ajit Behera, Nilotpala Bej, Vijaykumar S. Bhamare, Surendra Kumar Biswal, Ganesh R. Chate, Vaibhav R. Chate, Suman Chatterjee, Jaeyeop Choi, Bian Da, Satyabati Das, Biswajit Dash, Tapan Dash, Ding Ding, Mohammad Reza Golobostanfard, Ram K. Gupta, Vitaly Gurylev, T.V. Huynh, Ebenezer Olubunmi Ige, Adijat Omowumi Inyang, A.R. Jayakrishnan, Sambedan Jena, Li Jiahong, K. Kamakshi, Farkhondeh Khodabandeh, Hee-Je Kim, N.S. Kiran Kumar, Tejas Koushik, Raviraj M. Kulkarni, Sathasivam Pratheep Kumar, P. Maiti, Manila Mallik, Adhirath Mandal, Triveni Rajashekhar Mandlimath, Subash Chandra Mishra, Sudip Mondal, Anoop K. Mukhopadhyay, Tuan Anh Nguyen, Junghwan Oh, Takeo Oku, Ayodele James Oyejide, Kalpana Parida, Sumin Park, M. Pereira, Thuy Dung Nguyen Pham, Swastik Pradhan, Manisha Priyadarshini, G. Sudha Priyanga, Nikhil Rangaswamy, S. Tanuja Rani, Desigan Ravi, Ramya Ravichandran, R. Rugmini, Santosh Kumar Sahu, Rajashree Samantray, Santosh Sampath, S. Sarapure, K.C. Sekhar, Qian Shanhua, Manjunath Shettar, J.P.B. Silva, S.A. Srinivasan, Sathish Sugumaran, M. Tasneem, Phan Duc Tri, Keerthi Valsalan, Rajangam Vinodh, Chen Yi, Moonsuk Yi, Wang Yongguang, Zhao Yongwu, and Ni Zifeng

Published
2023
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6. Contributors

Author

Muhammad Aamir, Shuja Ahmed, Javeed Akhtar, Muhammad Awais Aslam, Amol C. Badgujar, V. Belessi, Neha Bisht, Sivasambu Böhm, Liliana P.T. Carneiro, Pritam Kishore Chakraborty, Silvia Colella, Carola Esposito Corcione, Olivier Degryse, Felipe M. de Souza, Sanjay R. Dhage, Steven John DiGregorio, Eleonora Ferraris, Nádia S. Ferreira, Octavio Garate, Snehraj Gaur, V. Georgakilas, Mehak Ghafoor, Sujit Kumar Ghosh, Gustavo Giménez, Antonella Giuri, Ram K. Gupta, Ritu Gupta, Owen James Hildreth, Žiga Jelen, Muhammad Kaleem Shabbir, Humaira Rashid Khan, Fahd Sikandar Khan, Muhammad Ejaz Khan, Pawan Kumar Khanna, S. Kiruthika, A. Koutsioukis, Andrea Listorti, F. Raquel Maia, Peter Majerič, Manab Mallik, Rocío Martínez-Flores, Dibakar Mondal, Leandro N. Monsalve, Sania Naseer, Gayatri Natu, Joaquim M. Oliveira, Gerko Oskam, Ayan Pal, Sudip Kumar Pal, Alexandra M.F.R. Pinto, Dena Pourjafari, Mallar Ray, Rui L. Reis, Aurora Rizzo, Geonel Rodríguez-Gattorno, Rebeka Rudolf, Miguel A. Ruiz-Gómez, Mainak Saha, M. Goreti F. Sales, Angel Samos-Puerto, Miriam Seiti, Abu Bakar Siddique, Rina Singh, Ahmed Shuja Syed, Amit Tewari, Khalid Hussain Thebo, Hanuma Reddy Tiyyagura, Ajay B. Urgunde, Lionel S. Veiga, Akash Verma, Maria Rosaria Vetrano, Thomas L. Willett, Brijesh Singh Yadav, and Gabriel Ybarra

Published
2023
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7. List of contributors

Author

CO Adetunji, null Ankit, Hira Aslam, MO Bamigboye, Najla Bentrad, Swati Bhati, Monika Bhattu, Dheeraj Bisht, Kemal Çetin, Anik Kumar Das, Adil Denizli, Santanu Dhara, Kamal Dua, CA Eziukwu, Hareem Fatima, Anshuman Gaurav, Deepak K Gupta, Humaira Hussain, A Inobeme, Suyambulingam Jone Kirubavathy, Shikha Kapil, Deepika Kathuria, T Kelani, Anglina Kisku, Deepak Kumar, Krishan Kumar, Suneel Kumar, Cansu İlke Kuru, Kalpana Madgula, M Maliki, Padmavati Manchikanti, JT Mathew, Sayan Mukherjee, Gunjan Nagpure, Arunadevi Natarajan, Vanya Nayak, Muhammad Yasin Naz, E Olori, BI Onyeachu, Ajay Pal, Nirmalya Pal, Rishi Paliwal, Mrituanjay D Pandey, Sadanand Pandey, Jhansi Lakshmi Parimi, Shruthy D. Pattathil, Lakshmi Madhuri Peddada, Ekta Poonia, Rishi Raj, Narender Ranga, Rohit Ranga, Nadia Razdan, Soumi Sadhu, Arpit Sand, Akshansh Sharma, Ishan Sharma, Monu Kumar Shukla, Shazia Shukrullah, Anita Singh, Jay Singh, Kshitij RB Singh, Ravindra Pratap Singh, Sachin Kumar Singh, Kunjbihari Sulakhiya, Houcine Touati, Jaya Tuteja, Fulden Ulucan-Karnak, Meenakshi Verma, Aparna Vyas, Yashraj Yadav, and Koray Şarkaya

Published
2023
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8. Contributors

Author

Pallavi Aggarwal, Anushka Bansal, Tanushree H. Choudhury, Tejendra K Gupta, Weida Hu, Benjamin Huet, Deep Jariwala, Jie Jiang, Baisali Kundu, Saurabh Lodha, Jinshui Miao, Himanshu Mishra, Prachi Mohanty, Suyash Rai, Joan M. Redwing, Prasana Kumar Sahoo, Madan Sharma, Aditya Singh, Rajendra Singh, Vijay K Singh, Sahin Sorifi, Anchal Srivastava, Jingya Su, Kartikey Thakar, Zhen Wang, and Xiaotian Zhang

Published
2023
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10. List of contributors

Author

Muhammad Aamir, Muhammad Adeel, Shuja Ahmed, Raju Ahmmed, Srinivas Ajjarapu, Javeed Akhtar, Mohammed Salim Akhter, Bilal Akram, Farman Ali, Nisar Ali, Magdalene A. Asare, Muhammad Ashraf, Muhammad Ayaz, Manahil Bakhtiar, Pratap Basim, Jaydip Bhaliya, Ram Naresh Bhargava, Glenda Biasotto, Muhammad Bilal, Talha Bin Emran, Emerson Rodrigues Camargo, Jonghyun Choi, Sandra Andrea Cruz, Cezar Augusto da Rosa, Caio Marcio Paranhos da Silva, Felipe M. de Souza, Francisco Nunes de Souza Neto, Basheerabegum Faniband, Rana Farhat, Gabriella Ribeiro Ferreira, Luiz Fernando Romanholo Ferreira, Jessica Caroline Ferreira Gimenez, Roger Gonçalves, Luiz Fernando Gorup, Kuruvalli Gouthami, Ram K. Gupta, Nazim Hussain, Shahid Hussain, Muhammad Imran, Hafiz M.N. Iqbal, Fatima Izhar, Uzma Jabeen, C. Jacinto-Hernández, Eduardo EJ Jara-Cornejo, Siddappa Kakkameli, Abdullah Khan, Adnan Khan, Ezzat Khan, Ibrahim Khan, Idrees Khan, Mohammad Mansoob Khan, Sabir Khan, Shahab Khan, Mallesh Kurakula, Lavanya Lakshminarayana, Shoomaila Latif, Junqiu Liu, Rosario López, Tehreem Mahmood, Sumeet Malik, Ahmed A. Mohamed, Shakti Chandra Mondal, Bianca Mortari, Sikandar I. Mulla, Junaid Munawar, Sania Naseer, Shahid Nawaz, Tuan Anh Nguyen, K.M. Nikita, Seema Panicker, Gautam M. Patel, Pinaz Pathan, Gino Picasso, Charles Pizan-Aquino, Abbas Rahdar, Juwel Rana, Tahir Rasheed, Ehsan Ullah Rashid, Atta Rasool, Mohsin Raza, Muhammad Rizwan, Gustavo Villela Rodrigues, Sami Rtimi, Gerson A. Ruiz-Córdova, Khalid Saeed, Shaukat Saeed, Nafeesa Sarfraz, Aniruddha Sarker, Carlos Henrique Scuracchio, Thiago Sequinel, Vraj Shah, Areej Shahbaz, Ahmed Shjua, Pau Loke Show, Maria D.P.T. Sotomayor, Vishwa D. Suthar, Tran Hong Thang, Sergio Espinoza Torres, Anees ur Rehman Qureshi, V. Veeraraghavan, Jaime Vega-Chacón, Javier E.L. Villa, Most. Waheda Rahman Ansary, Ademar Wong, Ghulam Yasin, Noor Zada, Shakeel Zeb, and Linlu Zhao

Published
2023
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13. List of contributors

Author

Shilpi Agarwal, Faheem Ahmed, Shefali Arora, Jaspreet Singh Aulakh, Richa Bhardwaj, Adrian Iulian Borhan, Ranjeet Kumar Brajpuriya, Georgiana Bulai, Ovidiu Florin Caltun, Daniela Carta, Maria F. Casula, Keun Hwa Chae, Edson Ferreira Chagas, Surjeet Chahal, Prakash Chand, Vishnu Chauhan, Anna Corrias, Gopal Datt, Ksh. Devarani Devi, Seema Devi, Archana Dhyani, Reena Dhyani, Ioan Dumitru, G.D. Dwivedi, A. Espinosa, Edson Silva Ferreira, Karsten Fleischer, Mohammad Reza Ganjali, Daniel Gherc, D. Gómez-Cerezo, Navdeep Goyal, Manjeet Singh Goyat, Deepika Gupta, Tejendra K. Gupta, Essia Hannachi, Mohd Hashim, Clare Hoskins, Sajid Husain, Alexandra Raluca Iordan, M. Jayasimhadri, Jayant Jogi, Amit Joshi, Deepika P. Joshi, S.K. Joshi, Asokan Kandasami, Baljeet Kaur, Abhimanyu Singh Khichi, B.H. Koo, Branko Koprivica, Akshay Kumar, Ankit Kumar, Ashok Kumar, Hemaunt Kumar, Manish Kumar, Parmod Kumar, Promod Kumar, Rajesh Kumar, Shalendra Kumar, Kavita Kumari, Mamta Latwal, Weon C. Lim, Danilo Loche, R. López-Méndez, C. Lozano-Pedraza, Keyvan Malaie, Bella Manshian, Mohan Chandra Mathpal, Jero Maze, Gavin Mountjoy, Manash Protim Mudoi, Daragh Mullarkey, Subhajit Nandy, Razia Nongjai, Adeolu Oluwasamni, Daniel Ortega, J. Ortega-Juliá, Vinod K. Paidi, Mircea Nicolae Palamaru, Ganesh Panday, S. Pavithra, Christophe Prigent, Sunita Rani, G. Ravi, M.V. Reddy, A. Sakunthala, Antonio Santana-Otero, E. Sanz-de Diego, S. Shankar, Aditya Sharma, Ram K. Sharma, Sonia Sharmin, Igor V. Shvets, Jitendra Pal Singh, Lalit Singh, Varsha Singh, S.K. Singhal, Shailey Singhal, Yassine Slimani, Stefaan Soenen, Maria A.G. Soler, Ramesh Chandra Srivastava, Sébastien Steydly, null Suman, H.C. Swart, F.J. Teran, O.P. Thakur, Elena Vasilica Trandafir, Martino Trassinelli, Garima Vashisht, Dominique Vernhet, Ankush Vij, and R. Yuvakumar

Published
2023
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14. List of contributors

Author

Mohd Adnan, Nawaf Alshammari, Adriano Aquino, Deepika Arora, Riadh Badraoui, Subhashini Bharathala, Shovon Bhattacharjee, Sanjeev Bhoi, Priyavand Bundela, Rajib Chandra Das, Priya Chauhan, Carlos Adam Conte-Junior, Saliha Dinc, Priyanka Dixit, Sami Dursun, Sonu Gandhi, Deepshikha Gupta, Rajeev Gupta, Tejendra K. Gupta, Md. Shafiul Islam, Sadaf Jahan, Priyanka Jangra, Bikash Chandra Jha, Meryem Kara, Andleeb Khan, Jaibir Kherb, Lakshmi Kanth Kotarkonda, Cansu İlke Kuru, Jiangong Liang, C. Raina MacIntyre, Ana Carolina de Morais Mirres, Sachin Mishra, Susmita Mondal, Geetanjali Negi, Siddhartha Panda, Annu Pandey, Nagma Parveen, Caifeng Ren, Paresh Kumar Samantaray, Deepshikha Shahdeo, Anurag Sharma, Arif Jamal Siddiqui, Bhanu Pratap Singh, Karunendra Singh, Ritu Singh, Tej Prakash Sinha, Ambikesh Soni, Leticia Tessaro, Gagan Kant Tripathi, S. Uday, Fulden Ulucan-Karnak, Roberto Vazquez-Munoz, Nishant Verma, and Emine Yavuz

Published
2023
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20. Highly sensitive noninvasive early lung cancer detection using DNA methylation topology in sputum-derived epithelial cells

Author

Harmik J. Soukiasian, Alexander Leung, Taryne Imai, Shika Bose, Sungjin Kim, Zab Mosenifar, Nirdesh K. Gupta, and Jian Tajbakhsh

Subjects
Pulmonary and Respiratory Medicine, Surgery, Thoracic: Lung Cancer, Cardiology and Cardiovascular Medicine
Abstract

OBJECTIVE: Sputum is a source of exfoliated respiratory epithelial cells transformed early in lung carcinogenesis. Malignant cells are hypomethylated and contain less genomic 5-methylcytosine (5mC). Validating a test that recognizes and quantifies aberrantly hypomethylated cells in sputum, we assessed its potential as a screening tool for detecting early-stage non–small cell lung cancer. METHODS: Cells extracted from sputum were immunofluorescence labeled with an anti-5-methylcytosine antibody and counterstained with 4′,6-diamidino-2-phenylindole (DAPI) delineating global nuclear DNA (gDNA). Via confocal scanning and 3-dimensional image analysis, fluorescence 5mC and DAPI signals were measured in segmented cell nuclei, and a 5mC/DAPI co-distribution map was generated for each imaged cell. Cells were classified as hypomethylated based on 5mC load and 5mC/DAPI co-distribution. The proportion of hypomethylated epithelial cells in the sputum determines whether a patient has lung cancer. RESULTS: A total of 88 subjects were enrolled: 12 healthy subjects; 34 high-risk subjects with benign chronic lung disorders (10 with chronic obstructive pulmonary disease, 24 with idiopathic pulmonary fibrosis), and 43 subjects with non–small cell lung cancer (27 with stage I-II and 16 with stage III-IV). The test identified early-stage non–small cell lung cancer and distinguished it from the high-risk group with 95.8% (95% confidence interval, 78.9-99.9) sensitivity and 41.2% (95% confidence interval, 24.6-59.3) specificity applying only 5mC, 95.8% (95% confidence interval, 78.9-99.9) sensitivity and 26.5% (95% confidence interval, 12.9-44.4) specificity using solely 5mC/DAPI index, and 100% (95% confidence interval, 98.7-100) sensitivity and 26.1% (95% confidence interval, 26.2-27.8) specificity with the combined parameters. CONCLUSIONS: We tested and validated a novel, noninvasive, highly sensitive screening test for non–small cell lung cancer. With the use of sputum, our test may impact lung cancer screening, evaluation of pulmonary nodules, and cancer surveillance algorithms.

Published
2022

21. Changing pattern of admissions for acute myocardial infarction in India during the COVID-19 pandemic

Author

Tom Devasia, Katyal Virender Kumar, Mrinal Kanti Das, Sreekanth Yerram, Narendranath Khanna, Nitish Naik, Geevar Zachariah, Swaminathan Nagarajan, Amal Kumar Khan, Neil Bardoloi, Pushkraj Gadkari, Gurpreet Singh Wander, Debabrata Roy, Kewal C. Goswami, Anshul Gupta, Bishav Mohan, Lekha Pathak, Cibu Mathew, Nitin Modi, Dipak Ranjan Das, Krishna Kishore Goyal, Bivin Wilson, Satyanarayan Routray, Venugopal Krishnan Nair, Shashi Bhushan Gupta, Chakkalakkal Prabhakaran Karunadas, Biswajit Majumder, Satyendra Tiwari, Sivabalan Maduramuthu, Rakesh Gupta, P.P. Mohanan, Kalaivani Mani, J. Ezhilan, Rahul Patil, K.R. Subramanyam, Santanu Guha, Saumitra Ray, Dinesh Choudhary, Rathinavel Sivakumar, Rituparna Baruah, Bishwa Bhushan Bharti, Santhosh Krishnappa, Manish Bansal, Rambhatla Suryanarayana Murty, Uday Jadhav, Prafulla Kerker, Siddiqui Kkh, Bateshwar Prasad Singh, Pradeep K. Hasija, Cholenahally Nanjappa Manjunath, Seemala Saikrishna Reddy, Karthik Tummala, Ashok Goyal, Natesh Bangalore Hanumanthappa, Sudeep Kumar, Ramakrishnan Sivasubramanian, Shashi Shekhar Chatterjee, Varun Shankar Narain, Diapk Sarma, Vitull K. Gupta, Sharad Chandra, Harsh Wardhan, Jayagopal Pathiyil Balagopalan, Rakesh Yadav, Girish Meennahalli Palleda, Vijay Kumar Garg, Pradip Kumar Deb, Sanjay Tyagi, C. B. Meena, Amit Malviya, Rishi Sethi, Ranjit Kumar Nath, Dorairaj Prabhakaran, Rabindra Nath Chakraborthy, A. Jabir, Pranab Jyoti Bhattacharyya, Manoranjan Mandal, Satish Kumar, Kumar Kenchappa, and Mohit Gupta

Subjects
Male, medicine.medical_treatment, Myocardial Infarction, 030204 cardiovascular system & hematology, Logistic regression, Ventricular Function, Left, 0302 clinical medicine, Pandemic, 030212 general & internal medicine, Myocardial infarction, Non-ST Elevated Myocardial Infarction, Mortality rate, Middle Aged, Low-and middle-income country, Acute myocardial infarction (AMI), Patient volume, Non ST elevation Myocardial infarction (NSTEMI) and outcome, Female, Original Article, Acute coronary syndrome, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), RD1-811, India, COVID-19 pandemic, 03 medical and health sciences, LMIC, Percutaneous Coronary Intervention, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, Pandemics, Management practices, Aged, business.industry, COVID-19, Percutaneous coronary intervention, Stroke Volume, medicine.disease, Cross-Sectional Studies, RC666-701, Communicable Disease Control, Time course, Emergency medicine, ST Elevation Myocardial Infarction, Surgery, business, ST elevation Myocardial infarction (STEMI), Demography
Abstract

Background: Admissions for acute myocardial infarction (MI) have declined significantly during the COVID-19 pandemic. The changes in the presentation, management, and outcomes of MI during the pandemic period are not well recognized, and data from low- and middle-income countries are limited. Methods: In this two-timepoint cross-sectional study involving 187 hospitals across India, patients admitted with MI between 15th March to 15th June in 2020 were compared with those admitted during the corresponding period of 2019. We sought to determine the changes in the number of admissions, management practices, and outcomes. Findings: We included 41,832 consecutive adults with MI. Admissions during the pandemic period (n = 16414) decreased by 35·4% as compared to the corresponding period in 2019 (n = 25418). We observed significant heterogeneity in this decline across India with the North zone reporting greater decline (-44·8%) than the South zone (-27·7%). The weekly average decrease in MI admissions in 2020 which peaked around the mid- study period, correlated negatively with the number of COVID cases (r = -0·48; r 2 = 0·2), but strongly correlated with the stringency of lockdown index (r = 0·95; r 2 = 0·90). On a multi-level logistic regression, admissions were lower in 2020 with older age categories, tier 1 cities, and centers with high patient volume, and teaching programs. Adjusted utilization rate of coronary angiography, and percutaneous coronary intervention decreased by 11·3%, and 5·9% respectively. However, the in-hospital mortality rates did not differ. Interpretation: The magnitude of reduction in MI admissions across India was not uniform. The nature, time course, and the patient demographics were different compared to reports from other countries, suggesting a significant impact due to the lockdown. These findings have important implications in managing MI admissions during the pandemic. Funding Statement: The study is funded by cardiological society of India. Declaration of Interests: Nothing to declare for all the authors. Ethics Approval Statement: Individual participating centres either obtained an ethical approval from respective Institutional ethics committees or a no objection certificate from the administration.

Published
2021

22. Ambulance Use, Health Outcomes, and Costs for Emergency Department Visits for Primary Diagnosis of Syncope in Canada

Author

Padma Kaul, Anamaria Savu, Arjun K. Gupta, Roopinder K. Sandhu, Satish R. Raj, and Robert S. Sheldon

Subjects
medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, biology, business.industry, Syncope (genus), Emergency department, biology.organism_classification, Health outcomes, Discharge status, lcsh:RC666-701, Emergency medicine, medicine, Original Article, Cardiology and Cardiovascular Medicine, business
Abstract

Background: Syncope is a common presentation to the emergency department (ED), yet little is known regarding patient mode of arrival. Methods: We identified patients ≥20 years old who presented to the ED with a primary diagnosis of syncope in Alberta and Ontario, Canada, between 2010 and 2016. Outcomes included 30-day in-hospital mortality, ED revisits, and rehospitalizations according to mode of arrival and discharge status. The estimated cost for ambulance use was calculated based on the provincial rates (Alberta CAD$385 and Ontario $240). Results: A total of 271,601 syncope presentations to the ED were identified and 60.7% arrived by ambulance. A total of 76.3% (n = 125,793) of ambulance users and 87.0% of self-presenters (n = 92,845) were discharged from the ED. Regardless of mode of arrival, discharged patients were younger with fewer comorbidities. Compared with ambulance users admitted, those discharged had lower in-hospital mortality (0.2% vs 3.5%, P < 0.001), ED revisits (4.4% vs 10.4%, P < 0.001), and rehospitalizations (3.6% vs 10.7%, P < 0.001). Discharged self-presenters also had significantly lower outcomes (P < 0.001, for each outcome) compared with admitted self-presenters. The estimated cost for ambulance use among patients discharged from the ED was $33,137,735. Conclusion: A majority of syncope patients arrived to the ED by ambulance, and over 3 quarters were directly discharged home. Although discharged patients had a favourable short-term prognosis, they incurred high transportation costs. Strategies aimed at preventing unnecessary ambulance use are needed. Résumé: Contexte: La syncope est une manifestation courante chez les patients qui se présentent au service des urgences; pourtant, on en sait peu sur la façon dont ces patients arrivent à l’hôpital. Méthodologie: Nous avons examiné les dossiers de patients âgés de 20 ans ou plus qui se sont présentés au service des urgences d’hôpitaux de l’Alberta et de l’Ontario, au Canada, et qui ont reçu un diagnostic de syncope entre 2010 et 2016. Les issues évaluées comprenaient la mortalité hospitalière à 30 jours, les nouvelles visites au service des urgences et les réadmissions à l’hôpital en fonction du mode d’arrivée et du statut au moment de la sortie de l’hôpital. Le coût estimatif des services d’ambulance a été calculé à partir des tarifs provinciaux (385 $ en Alberta et 240 $ en Ontario). Résultats: En tout, 271 601 cas de syncope ont été recensés dans les services des urgences; dans 60,7 % des cas, le patient est arrivé en ambulance. Au total, 76,3 % (n = 125 793) des patients arrivés en ambulance et 87,0 % des patients qui se sont présentés d’eux-mêmes (n = 92 845) ont reçu leur congé du service des urgences. Quel que soit leur mode d’arrivée, les patients qui ont reçu leur congé étaient plus jeunes et présentaient moins d’affections concomitantes. Chez les patients arrivés en ambulance, ceux qui ont reçu leur congé ont affiché des résultats inférieurs à ceux qui ont été admis à l’hôpital quant à la mortalité hospitalière (0,2 % vs 3,5 %, p < 0,001), aux nouvelles visites au service des urgences (4,4 % vs 10,4 %, p < 0,001) et aux réadmissions à l’hôpital (3,6 % vs 10,7 %, p < 0,001). Dans le cas des patients qui se sont présentés d’eux-mêmes, l’incidence des issues évaluées était aussi plus faible chez ceux qui ont reçu leur congé (p < 0,001 pour chaque issue) que chez ceux qui ont été admis à l’hôpital. Le coût estimatif du recours aux services d’ambulance par les patients qui ont reçu leur congé du service des urgences se chiffrait à 33 137 735 $. Conclusion: La majorité des patients subissant une syncope sont arrivés au service des urgences en ambulance, et plus des trois quarts ont reçu directement leur congé à la maison. Bien que le pronostic à court terme des patients ayant reçu leur congé du service des urgences ait été favorable, ces patients ont dû payer des frais de transport élevés. Des stratégies visant à prévenir le recours inutile aux services d’ambulance s’imposent.

Published
2020

23. Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study

Author

Fiina Närhi, S Ramani Moonesinghe, Susan D Shenkin, Thomas M Drake, Rachel H Mulholland, Cara Donegan, Jake Dunning, Cameron J Fairfield, Michelle Girvan, Hayley E Hardwick, Antonia Ho, Gary Leeming, Jonathan S Nguyen-Van-Tam, Riinu Pius, Clark D Russell, Catherine A Shaw, Rebecca G Spencer, Lance Turtle, Peter J M Openshaw, J Kenneth Baillie, Ewen M Harrison, Malcolm G Semple, Annemarie B Docherty, Peter JM Openshaw, Gail Carson, Beatrice Alex, Petros Andrikopoulos, Benjamin Bach, Wendy S Barclay, Debby Bogaert, Meera Chand, Kanta Chechi, Graham S Cooke, Ana da Silva Filipe, Thushan de Silva, Gon¸alo dos Santos Correia, Marc-Emmanuel Dumas, Tom Fletcher, Christopher A Green, William Greenhalf, Julian Griffin, Rishi K Gupta, Julian A Hiscox, Antonia YW Ho, Peter W Horby, Samreen Ijaz, Say Khoo, Paul Klenerman, Andrew Law, Matthew Lewis, Sonia Liggi, Wei Shen Lim, Lynn Maslen, Alexander J Mentzer, Laura Merson, Alison M Meynert, Shona C Moore, Mahdad Noursadeghi, Michael Olanipekun, Anthonia Osagie, Massimo Palmarini, Carlo Palmieri, William A Paxton, Georgios Pollakis, Nicholas Price, Andrew Rambaut, David L Robertson, Vanessa Sancho-Shimizu, Caroline Sands, Janet T Scott, Louise Sigfrid, Tom Solomon, Shiranee Sriskandan, David Stuart, Charlotte Summers, Olivia V Swann, Zoltan Takats, Panteleimon Takis, Richard S Tedder, AA Roger Thompson, Emma C Thomson, Ryan S Thwaites, Lance CW Turtle, Maria Zambon, Hayley Hardwick, Chloe Donohue, Fiona Griffiths, Wilna Oosthuyzen, Lisa Norman, Stephen R Knight, Kenneth A Mclean, Derek Murphy, Jo Dalton, Egle Saviciute, Stephanie Roberts, Janet Harrison, Laura Marsh, Marie Connor, Sophie Halpin, Clare Jackson, Carrol Gamble, Daniel Plotkin, James Lee, Murray Wham, Sara Clohisey, Ross Hendry, James Scott-Brown, Victoria Shaw, Sarah E McDonald, Seán Keating, Katie A. Ahmed, Jane A Armstrong, Milton Ashworth, Innocent G Asiimwe, Siddharth Bakshi, Samantha L Barlow, Laura Booth, Benjamin Brennan, Katie Bullock, Benjamin WA Catterall, Jordan J Clark, Emily A Clarke, Sarah Cole, Louise Cooper, Helen Cox, Christopher Davis, Oslem Dincarslan, Chris Dunn, Philip Dyer, Angela Elliott, Anthony Evans, Lorna Finch, Lewis WS Fisher, Terry Foster, Isabel Garcia-Dorival, Philip Gunning, Catherine Hartley, Rebecca L Jensen, Christopher B Jones, Trevor R Jones, Shadia Khandaker, Katharine King, Robyn T. Kiy, Chrysa Koukorava, Annette Lake, Suzannah Lant, Diane Latawiec, Lara Lavelle-Langham, Daniella Lefteri, Lauren Lett, Lucia A Livoti, Maria Mancini, Sarah McDonald, Laurence McEvoy, John McLauchlan, Soeren Metelmann, Nahida S Miah, Joanna Middleton, Joyce Mitchell, Ellen G Murphy, Rebekah Penrice-Randal, Jack Pilgrim, Tessa Prince, Will Reynolds, P. Matthew Ridley, Debby Sales, Victoria E Shaw, Rebecca K Shears, Benjamin Small, Krishanthi S Subramaniam, Agnieska Szemiel, Aislynn Taggart, Jolanta Tanianis-Hughes, Jordan Thomas, Erwan Trochu, Libby van Tonder, Eve Wilcock, J. Eunice Zhang, Lisa Flaherty, Nicole Maziere, Emily Cass, Alejandra Doce Carracedo, Nicola Carlucci, Anthony Holmes, Hannah Massey, Lee Murphy, Sarah McCafferty, Richard Clark, Angie Fawkes, Kirstie Morrice, Alan Maclean, Nicola Wrobel, Lorna Donelly, Audrey Coutts, Katarzyna Hafezi, Louise MacGillivray, Tammy Gilchrist, Kayode Adeniji, Daniel Agranoff, Ken Agwuh, Dhiraj Ail, Erin L. Aldera, Ana Alegria, Sam Allen, Brian Angus, Abdul Ashish, Dougal Atkinson, Shahedal Bari, Gavin Barlow, Stella Barnass, Nicholas Barrett, Christopher Bassford, Sneha Basude, David Baxter, Michael Beadsworth, Jolanta Bernatoniene, John Berridge, Colin Berry, Nicola Best, Pieter Bothma, David Chadwick, Robin Brittain-Long, Naomi Bulteel, Tom Burden, Andrew Burtenshaw, Vikki Caruth, Duncan Chambler, Nigel Chee, Jenny Child, Srikanth Chukkambotla, Tom Clark, Paul Collini, Catherine Cosgrove, Jason Cupitt, Maria-Teresa Cutino-Moguel, Paul Dark, Chris Dawson, Samir Dervisevic, Phil Donnison, Sam Douthwaite, Andrew Drummond, Ingrid DuRand, Ahilanadan Dushianthan, Tristan Dyer, Cariad Evans, Chi Eziefula, Chrisopher Fegan, Adam Finn, Duncan Fullerton, Sanjeev Garg, Atul Garg, Effrossyni Gkrania-Klotsas, Jo Godden, Arthur Goldsmith, Clive Graham, Elaine Hardy, Stuart Hartshorn, Daniel Harvey, Peter Havalda, Daniel B Hawcutt, Maria Hobrok, Luke Hodgson, Anil Hormis, Michael Jacobs, Susan Jain, Paul Jennings, Agilan Kaliappan, Vidya Kasipandian, Stephen Kegg, Michael Kelsey, Jason Kendall, Caroline Kerrison, Ian Kerslake, Oliver Koch, Gouri Koduri, George Koshy, Shondipon Laha, Steven Laird, Susan Larkin, Tamas Leiner, Patrick Lillie, James Limb, Vanessa Linnett, Jeff Little, Mark Lyttle, Michael MacMahon, Emily MacNaughton, Ravish Mankregod, Huw Masson, Elijah Matovu, Katherine McCullough, Ruth McEwen, Manjula Meda, Gary Mills, Jane Minton, Mariyam Mirfenderesky, Kavya Mohandas, Quen Mok, James Moon, Elinoor Moore, Patrick Morgan, Craig Morris, Katherine Mortimore, Samuel Moses, Mbiye Mpenge, Rohinton Mulla, Michael Murphy, Megan Nagel, Thapas Nagarajan, Mark Nelson, Lillian Norris, Matthew K. O'Shea, Igor Otahal, Marlies Ostermann, Mark Pais, Selva Panchatsharam, Danai Papakonstantinou, Hassan Paraiso, Brij Patel, Natalie Pattison, Justin Pepperell, Mark Peters, Mandeep Phull, Stefania Pintus, Jagtur Singh Pooni, Tim Planche, Frank Post, David Price, Rachel Prout, Nikolas Rae, Henrik Reschreiter, Tim Reynolds, Neil Richardson, Mark Roberts, Devender Roberts, Alistair Rose, Guy Rousseau, Bobby Ruge, Brendan Ryan, Taranprit Saluja, Matthias Schmid, Aarti Shah, Prad Shanmuga, Anil Sharma, Anna Shawcross, Jeremy Sizer, Manu Shankar-Hari, Richard Smith, Catherine Snelson, Nick Spittle, Nikki Staines, Tom Stambach, Richard Stewart, Pradeep Subudhi, Tamas Szakmany, Kate Tatham, Jo Thomas, Chris Thompson, Robert Thompson, Ascanio Tridente, Darell Tupper-Carey, Mary Twagira, Nick Vallotton, Rama Vancheeswaran, Lisa Vincent-Smith, Shico Visuvanathan, Alan Vuylsteke, Sam Waddy, Rachel Wake, Andrew Walden, Ingeborg Welters, Tony Whitehouse, Paul Whittaker, Ashley Whittington, Padmasayee Papineni, Meme Wijesinghe, Martin Williams, Lawrence Wilson, Sarah Sarah, Stephen Winchester, Martin Wiselka, Adam Wolverson, Daniel G Wootton, Andrew Workman, Bryan Yates, Peter Young, UK Research and Innovation, National Institute for Health Research, UKRI MRC COVID-19 Rapid Response Call, University of Edinburgh, Nuffield Department of Medicine [Oxford, UK] (Big Data Institute), University of Oxford [Oxford], Public Health England [London], University of Nottingham, UK (UON), University of Liverpool, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Imperial College London - National Heart and Lung Institute, and Division of Computational and Systems Medicine, Imperial College London, London, SW7 2AZ, UK

Subjects
Adolescent, [SDV]Life Sciences [q-bio], Medicine (miscellaneous), COVID-19, Health Informatics, World Health Organization, United Kingdom, COVID-19 Drug Treatment, Cohort Studies, Health Information Management, Adrenal Cortex Hormones, Pregnancy, Humans, Decision Sciences (miscellaneous), Female, Prospective Studies, ISARIC4C investigators
Abstract

Background Dexamethasone was the first intervention proven to reduce mortality in patients with COVID-19 being treated in hospital. We aimed to evaluate the adoption of corticosteroids in the treatment of COVID-19 in the UK after the RECOVERY trial publication on June 16, 2020, and to identify discrepancies in care. Methods We did an audit of clinical implementation of corticosteroids in a prospective, observational, cohort study in 237 UK acute care hospitals between March 16, 2020, and April 14, 2021, restricted to patients aged 18 years or older with proven or high likelihood of COVID-19, who received supplementary oxygen. The primary outcome was administration of dexamethasone, prednisolone, hydrocortisone, or methylprednisolone. This study is registered with ISRCTN, ISRCTN66726260. Findings Between June 17, 2020, and April 14, 2021, 47 795 (75·2%) of 63 525 of patients on supplementary oxygen received corticosteroids, higher among patients requiring critical care than in those who received ward care (11 185 [86·6%] of 12 909 vs 36 415 [72·4%] of 50 278). Patients 50 years or older were significantly less likely to receive corticosteroids than those younger than 50 years (adjusted odds ratio 0·79 [95% CI 0·70–0·89], p=0·0001, for 70–79 years; 0·52 [0·46–0·58], p80 years), independent of patient demographics and illness severity. 84 (54·2%) of 155 pregnant women received corticosteroids. Rates of corticosteroid administration increased from 27·5% in the week before June 16, 2020, to 75–80% in January, 2021. Interpretation Implementation of corticosteroids into clinical practice in the UK for patients with COVID-19 has been successful, but not universal. Patients older than 70 years, independent of illness severity, chronic neurological disease, and dementia, were less likely to receive corticosteroids than those who were younger, as were pregnant women. This could reflect appropriate clinical decision making, but the possibility of inequitable access to life-saving care should be considered. Funding UK National Institute for Health Research and UK Medical Research Council.

Published
2022
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24. Contributors

Author

Manoj Aggarwal, James Akingbasote, Arturo Anadón, Gregory J. Anger, Anthony E. Archibong, Irma Ares, Michael Aschner, Daiana S. Avila, Denise C. Bailey, Norman J. Barlow, Sudheer Beedanagari, P.P. Beltyukov, Karyn Bischoff, Carina Rodrigues Boeck, William M. Bracken, Emily Brehm, Richard M. Breyer, Susan Bright-Ponte, Mirjana Milosevic Brockett, Luisa Campagnolo, Edward W. Carney, Andrew Charrette, Sandrine Fleur Chebekoue, Catheryne Chiang, Wei-Chun Chou, Jane K. Cleal, Toby B. Cole, Daniel Cook, Robert W. Coppock, Lucio G. Costa, Margarita Curras-Collazo, Wanying Dai, Khoi Dao, Rosane Souza Da Silva, T. Zane Davis, Francisco Dominguez, Robin B. Doss, Margitta M. Dziwenka, Brian Enright, Carmen Estevan, Timothy J. Evans, Anna M. Fan, Marcelo Farina, Suzanne E. Fenton, Ayhan Filazi, Vanessa A. Fitsanakis, Rex FitzGerald, John Flaskos, Jodi A. Flaws, S.J.S. Flora, Vekataseshu K. Ganjam, Dale R. Gardner, Ramesh C. Garg, Jacqueline M. Garrick, Vincent F. Garry, Janee Gelineau-van Waes, Keith M. Godfrey, Yu V. Golubentseva, Roberto González-Martín, Benedict T. Green, Consuelo Guerri, Kavita Gulati, P.K. Gupta, Ramesh C. Gupta, Rekha K. Gupta, Najla Guthrie, Jeffery O. Hall, Alan J. Hargreaves, Kenneth J. Harris, Bridgett N. Hill, Corey J. Hilmas, Alan M. Hoberman, Karin S. Hougaard, Sinan Ince, Poorni R. Iyer, Nicklas R. Jacobsen, Starling Kalpana, Ramesh Kandimalla, Arthi Kanthasamy, Anumantha Kanthasamy, N.S. Khlebnikova, Nils Klüver, Prasada Rao S. Kodavanti, Kannan Krishnan, Shaila Kulkarni, Ozgur Kuzukiran, Rajiv Lall, Jessica Legradi, Rohan M. Lewis, Elise M. Lewis, Xin Li, Pinpin Lin, Bommanna G. Loganathan, Ivo F. Machado, Brinda Mahadevan, Susan L. Makris, Jitendra K. Malik, Ana Paula Marreilha dos Santos, Judit Marsillach, María Rosa Martínez-Larrañaga, María Aránzazu Martínez, Klara Matouskova, Roger O. McClellan, Dejan Milatovic, Ali Mustafa Mohammed, Thomas J. Montine, Peter Møller, Pushpinder Kaur Multani, Mingwei Ni, Efstathios Nikolaidis, Meliton N. Novilla, Stephanie Padilla, Carlos M. Palmeira, David Pamies, Manesh Kumar Panner Selvam, María Pascual, Jayant Patwa, Ashley Phillips, Micheline Piquette-Miller, V.B. Popov, M. Margaret Pratt, G.A. Protasova, Nishant Rai, João Ramalho-Santos, Aramandla Ramesh, Kausik Ray, Arunabha Ray, Aiguo Ren, Stephen J. Renaud, Drucilla J. Roberts, Lu Rongzhu, Magdalini Sachana, Heidi Sahlman, Nitin Saini, Vandna Saini, L.V. Shabasheva, Abha Sharma, Suresh C. Sikka, Marilyn Helen Silva, Ilker Simsek, Rajkumar Singh Kalra, Anita Sinha, Miguel A. Sogorb, Offie P. Soldin, Chunjuan Song, Ajay Srivastava, Szabina A. Stice, Tammy E. Stoker, Clinton A. Stonecipher, Sandra Szlapinski, Shihori Tanabe, Arun Tatiparthi, João Batista Teixeira da Rocha, Suresh Kumar Thokchom, Belen Tornesi, Vanda Torous, Peter Truran, Matthew C. Valdez, Laura N. Vandenberg, Neil Vargesson, Eugenio Vilanova, Kirsi H. Vähäkangas, Suryanarayana V. Vulimiri, Genoa R. Warner, Kevin D. Welch, Daniel C. Williams, Moges Woldemeskel, Jae-Ho Yang, Zhaobao Yin, Xiaoyou Ying, Begum Yurdakok-Dikmen, Snjezana Zaja-Milatovic, and Changqing Zhou

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2022
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25. Contributors

Author

Ismail Abiola Adebayo, Azeez Omoniyi Adeoye, Adam Moyosore Afodun, Moniem B. Ahad, Kamoldeen Abiodun Ajijolakewu, Angel Josabad Alonso-Castro, Alice Amoding, Sagar Arya, Tabinda Athar, Muhammad Ashar Ayub, Arpita Banerjee, Monika Bansal, Twaha Ateenyi Basamba, Ashish Bedi, Isha Bedi, Sashidhar R. Beedu, Rouf Ahmad Bhat, Sasha Cardozo, Candy Carranza-Álvarez, Ramón Fernando García-De La Cruz, Gowhar Hamid Dar, Xiaorong Fan, Iqra Farooq, Zia Ur Rahman Farooqi, Nafeesa Farooq Khan, Saksham Garg, Muhammad Imran Ghani, Mir Z. Gul, Charu Gupta, Mahendra K. Gupta, Aukib Habib, Younis Ahmad Hajam, Khalid Rehman Hakeem, Insha Hameed, Humaira Hussain, Muhammad Mahroz Hussain, Predrag Ilic, Rashid Iqbal, Akanksha Jaiswar, Muatasim Jan, Rahul Singh Jasrotia, Rajdeep Jaswal, Manmeet Kaur, Navneet Kaur, Iqra F. Khan, Satya Prakash Khuntia, Md. Khursheed, Rajesh Kumar, Moline Severino Lemos, Mengyun Liu, Bisma Malik, Sweeta Manhas, Javid Manzoor, Tawseef A. Mir, Ghulam Murtaza, Umair Mustafa, Misbah Naz, Núbia Alexandre de Melo Nunes, Anjali Pathak, Tanveer Bilal Pirzadah, Amauri Ponce-Hernández, Paola Lucero Pérez, Ayesha Abdul Qadir, Mir S. Rabani, Shilpa Raina, Raksha Rani, Seema Rashid, Summia Rehman, Sobia Riaz, Umair Riaz, Arpita Roy, Jane Alexander Ruley, Karuna Rupula, Muhammad Fahad Sardar, Mohammad Sarraf, Riya Sharma, Shivani Sharma, Sheikh Mansoor, Harpreet Singh Sodhi, Hiralal Sonawane, Fernanda Maria Policarpo Tonelli, Flávia Cristina Policarpo Tonelli, Shivani Tripathi, John Baptist Tumuhairwe, Anjani Kumar Upadhyay, Bilal A. Wani, Khursheed Ahmad Wani, and Shabir H. Wani

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2022
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26. List of contributors

Author

Mohd Azmuddin Abdullah, Charles Oluwaseun Adetunji, Mohd Imran Ahamed, Muhammad Sajid Hamid Akash, Sadia Akram, Sana Ali, Telli Alia, Mafalda R. Almeida, Fereshteh S. Amani, Osikemekha Anthony Anani, Sherly Antony, S. Anuradha, Naushad Anwar, Marília T. Araújo, K.B. Arun, Pramod K. Avti, Hamidreza Bagheri, Shiv Bahadur, Bubun Banerjee, Syqa Banoo, Andreea Irina Barzic, Masrat Bashir, K. Bhanu Revathi, Parameswaran Binod, Arunima Biswas, Arushi Chauhan, Arun chelliah, Bruna Galdorfini Chiari-Andréo, Glauber Cruz, Julie Brenda Santos da Silva, Ankita Das, Alessandra Teixeira de Macedo, Felipe M. de Souza, Maria Eliziane Pires de Souza, Biswajit Debnath, Sunita Devi, Vividha Dhapte-Pawar, Surender Duhan, Apurba Dutta, Shibitha Emmanual, Mara G. Freire, Isadora Frigieri, Anirban Garg, Saswati Gharami, Sib Sankar Giri, Ram K. Gupta, Rodrigo Assunção Holanda, Hanaa Ali Hussein, Shah Imtiaz, Tenzin Ingsel, Abel Inobeme, S.K. Manirul Islam, Manojkumar Jadhao, Christine Jeyaseelan, Racheal John, Ritika Joshi, Qari Muhammad Kaleem, Gurpreet Kaur, Satish Khasa, Priya Krishna, Atul Kumar, Krishnamoorthy Lalitha, Aravind Madhavan, Flávia F. Magalhães, D. Manikandan, Laura Arruda Mascaro, G. Meghana, Piyush Pradeep Mehta, S.U. Mohammed Riyaz, Ali Mohebbi, Mina Naderi, Sumaira Naeem, Subbiah Nagarajan, Jawayria Najeeb, Nayra Najeeb, S. Nalini, João C.F. Nunes, Olugbemi Tope Olaniyan, Julius Kola Oloke, Wadzani Dauda Palnam, Aarati Panchbhai, Ashok Pandey, Se Chang Park, S. Parveen, Kamla Pathak, Satyanarayan Pattnaik, Waqar Pervaiz, Anu Priya, Apoorv Rana, Prasanth Rathinam, Kanwal Rehman, Reshmy R., Adones Almeida Rocha, Amrita Saha, Awotunde Oluwasegun Samson, Namrata Sangwan, Audirene Amorim Santana, Julliana Ribeiro Alves dos Santos, B. Saravanakumar, Moumita Sardar, Solanki Sarkar, Diganta Sarma, S. Sathiyamurthi, Karishma Shetty, K. Shinomol George, Raveendran Sindhu, Vandana Singh, T. Stalin Dhas, T.U. Sukumaran, Kalpana Swain, Deborah Sybil, Ana P.M. Tavares, Sheikh Muhammad Usman, Rualdo Valderrama Filho, Vadanasundari Vedarethinam, Francis Victor, Shreya Walvekar, Khushwant S. Yadav, Soma Yasaswi, and Amanda Karina de Paula Zago

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2022
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28. Contributors

Author

Sherief Abdulla, Josh Agarwal, K.N. Apinaya Prethi, Parth Arora, Ananya Banerjee, Ketaki Barde, Shailesh Pramod Bendale, Lamia Berkani, Robin Singh Bhadoria, Ajay Kumar Bharti, Shobhit Bhatnagar, Naman Bhoj, Nilesh Chandra, Santosh L. Deshpande, Anuj Diwedi, Rahul Kumar Dubey, Imo J. Eyoh, A. Ganesan, Ashray Gupta, Manu K. Gupta, Marjan Gusev, Rajeswary Hari, U. Hariharan, Mohd Haroon, null Harshvardhan, Nandyala Hemachandra, Shashi Jain, G.O. Jijina, A. Kalaivani, Rohit B. Kaliwal, N. Kanimozhi, N. Kanya, Ramgopal Kashyap, Harsh Kashyap, Imene Lydia Kerboua, Param Khakhar, Santosh Kumar, Swarup Kumar, Michael Manry, Elezabeth Mathew, Eesha Mishra, Vadivel S. Murugesan, G. Nalinashini, S. Nithya, Megha Nivurruti, Emmanuel E. Nyoho, Vipin Pal, Rajiv Pandey, Dharmendra Pathak, Anju S. Pillai, R.S. Ponmagal, Jayashree Rajesh Prasad, Rajesh Shardanand Prasad, Boppuru Rudra Prathap, Surendra Rahamatkar, K. Rajkumar, Chinmay Rane, Archana Sahai, M. Sangeetha, Vijayalakshmi Saravanan, Rahul Saxena, S. Sendilvelan, Shambhavi Sharma, R. Shree Charran, Zeeshan Ali Siddiqui, Mukul Singh, Vaishali Singh, P. Solainayagi, Raghavendra Sriram, K. Sujatha, Ashish Tiwari, Kanishka Tyagi, Uduak A. Umoh, Isaac Woungang, Anju Yadav, and Sofiane Zeghoud

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2022
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30. List of contributors

Author

B.A. Aderibigbe, Aakriti Aggarwal, S. Alven, V. Anilkumar, M.S. Anju, R.K. Athira, Anugya Bhatt, B. Buyana, Cátia S.D. Cabral, Madhavi Latha Chinta, Ilídio J. Correia, Duarte de Melo-Diogo, Z. Feketshane, Pradeep Kumar Gandam, Samridhi Garg, Sneh Gautam, Ashna Gauthaman, Mariana F.P. Graça, Amlan Gupta, Sweta K. Gupta, Clare Hoskins, Zahid Hussain, Ruchi Jhonsa, Ranjith S. Kartha, Naresh Kasoju, Shahzeb Khan, Anand Krishnan, Ritesh Kumar, P. Lekshmi, Ernest Man, João F. Mano, Narayan Chandra Mishra, Mohd Cairul Iqbal Mohd Amin, André F. Moreira, Sunny Mukherjee, Senthilkumar Muthusamy, Renjith P. Nair, Asha V. Nath, X. Nqoro, Mehmet Evren Okur, Ece Özcan Bülbül, Sreenivasa Rao Parcha, Sushma Priya, A. Priyanka, Sripriya Ramasamy, Subha Narayan Rath, Mutasem Rawas-Qalaji, A.S. Safeena, Mahesh K. Sah, Lúcia F. Santos, Rai Muhammad Sarfraz, Panoraia I. Siafaka, Monica Sikka, Hemant Singh, A. Sofia Silva, Mohammad Sohail, Lynda V. Thomas, Hnin Ei Thu, and Neslihan Üstündağ Okur

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2022
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32. Contributors

Author

Banafshe Abadi, Nor Hasmaliana binti Abdul Manas, Raquel Silva Araújo, Sayang Baba, Parsa Bazdar, Thomas Beuvier, Muhammad Bilal, Parameswaran Binod, Frank Boury, Nela Buchtová, Juliana Cancino-Bernardi, Valéria Maria de Oliveira Cardoso, Guillermo R. Castro, Zafer Ceylan, Rakshita Chaudhary, Edson José Comparetti, Thomas Cordonnier, María L. Cuestas, Maria Alice de Oliveira, Daniel Joe Dailin, Tomás Brito Devoto, Batul Diwan, Mustafa Durmus, Touba Eslaminejad, João Paulo Fabi, Leonardo Miziara Barboza Ferreira, Natália Ferreira (Noronha), Moreno Galleni, Emmanuel Garcion, Nisha Gaur, Alain Gibaud, Ram K. Gupta, Salehhuddin Hamdan, Zanariah Hashim, Leila N. Hassani, François Hindre, Fitrien Husin, Jayanant Iemsam-arng, Rosli Md. Illias, Christine Jerôme, Norsuhada Abdul Karim, Koray Korkmaz, María F. Ladetto, María J. Limeres, Marina Guimarães Carvalho Machado, Samuel L. Martins, Siti Alyani Binti Mat, Gincy Marina Mathew, Aizi Nor Mazila Ramli, Renata Rank Miranda, Vishal Mishra, Vanessa Carla Furtado Mosqueira, Ida Idayu Muhamad, Mahshid Moballegh Nasery, Hoang Lam Nguyen, Tuan Anh Nguyen, Nor Farahiyah Aman Nor, Ashok Pandey, Sarva Mangala Praveena, Reshmy R, Bathabile Ramalapa, Maria H. Ribeiro, Thiécla Katiane Osvaldt Rosales, Nasrin Seyedpour, Shalyda Shaarani, Raveendran Sindhu, Mohan P Singh, Nidhi Singh, Veer Singh, Deepa Thomas, María A. Toscanini, Yilmaz Ucar, Manisha Verma, Manoj Kumar Verma, Nur Izyan Wan Azelee, Harisun Yaakob, Binti Abang Zaidel, Dayang Norulfairuz Abang Zaidel, Noorazwani Zainol, Siti Fatimah Zaharah Mohd Fuzi, and Valtencir Zucolotto

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2022
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34. A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions

Author

Evan S, Dellon, Paneez, Khoury, Amanda B, Muir, Chris A, Liacouras, Ekaterina, Safroneeva, Dan, Atkins, Margaret H, Collins, Nirmala, Gonsalves, Gary W, Falk, Jonathan M, Spergel, Ikuo, Hirano, Mirna, Chehade, Alain M, Schoepfer, Calies, Menard-Katcher, David A, Katzka, Peter A, Bonis, Albert J, Bredenoord, Bob, Geng, Elizabeth T, Jensen, Robert D, Pesek, Paul, Feuerstadt, Sandeep K, Gupta, Alfredo J, Lucendo, Robert M, Genta, Girish, Hiremath, Emily C, McGowan, Fouad J, Moawad, Kathryn A, Peterson, Marc E, Rothenberg, Alex, Straumann, Glenn T, Furuta, and Seema S, Aceves

Subjects
Adult, Consensus, Hepatology, Immunology, Gastroenterology, Eosinophilic Esophagitis, macromolecular substances, Severity of Illness Index, Endoscopy, Gastrointestinal, Enteritis, Article, Gastritis, Eosinophilia, Humans, Immunology and Allergy, Child, 610 Medicine & health, 360 Social problems & social services
Abstract

BACKGROUND & AIMS Disease activity and severity of eosinophilic esophagitis (EoE) dictate therapeutic options and management, but the decision-making process for determining severity varies among practitioners. To reduce variability in practice patterns and help clinicians monitor the clinical course of the disease in an office setting, we aimed to create an international consensus severity scoring index for EoE. METHODS A multidisciplinary international group of adult and pediatric EoE researchers and clinicians, as well as non-EoE allergy immunology and gastroenterology experts, formed 3 teams to review the existing literature on histology, endoscopy, and symptoms of EoE in the context of progression and severity. A steering committee convened a 1-day virtual meeting to reach consensus on each team's opinion on salient features of severity across key clinicopathologic domains and distill features that would allow providers to categorize disease severity. RESULTS Symptom features and complications and inflammatory and fibrostenotic features on both endoscopic and histologic examination were collated into a simplified scoring system-the Index of Severity for Eosinophilic Esophagitis (I-SEE)-that can be completed at routine clinic visits to assess disease severity using a point scale of 0-6 for mild, 7-14 for moderate, and ≥15 for severe EoE. CONCLUSIONS A multidisciplinary team of experts iteratively created a clinically usable EoE severity scoring system denominated "I-SEE" to guide practitioners in EoE management by standardizing disease components reflecting disease severity beyond eosinophil counts. I-SEE should be validated and refined using data from future clinical trials and routine clinical practice to increase its utilization and functionality.

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2022
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35. Contributors

Author

Temitope Olabisi Abodunrin, Abel G. Achumi, Kayode Adesina Adegoke, Rhoda Oyeladun Adegoke, Waqar Ahmed, Saira Ajmal, Solomon Oluwaseun Akinnawo, Miroslav Almáši, Christina Angelara, K. Archana, Nikolaos Argirusis, Christos Argirusis, Satyajeet Arya, A. Asif, Hafiz Muhammad Asif, Pierre-Henri Aubert, Figen Balo, Deborah Temitope Bankole, Hemanth Kumar Beere, Olugbenga Solomon Bello, Kaushalya Bhakar, Dan J.L. Brett, Xian-He Bu, Vikas Chaudhary, Aibing Chen, Mingren Cheng, Akash Deep, Godshelp Osas Egharevba, Fehim Fındık, Vellaichamy Ganesan, Debasis Ghosh, Mohammad Reza Golobostanfard, Ram K. Gupta, Rupali Gupta, Payam Hayati, Guanjie He, Shumaila Ibraheem, Sehrish Ibrahim, Tenzin Ingsel, Donpaul Jose, Eirini Kanellou, Liqun Kang, Antonis Karantonis, Muhammad Ali Khan, Subratanath Koner, Lingjun Kong, Anuj Kumar, Dinesh Kumar, Parveen Kumar, Praveen Lakhera, Randy W. Larsen, Hugo Lavillunière, Yiyang Liu, Jianqiang Liu, Xinying Liu, Xu Lu, Zachary L. Magnuson, Ghodrat Mahmoudi, S. Maitra, Nobanathi Wendy Maxakato, Jacob M. Mayers, Maria Mechili, R. Mitra, Sanna Kotrappanavar Nataraj, T.K. Nath, Meena Nemiwal, Tuan Anh Nguyen, Solomon Oluwole Oladeji, Adetola Christianah Oladipo, Kabir O. Otun, Demet Ozer, Mala Pamei, Ying Pan, Pavlos K. Pandis, Thuan-Nguyen Pham-Truong, Erfan Pourshaban, Rangaswamy Puttaswamy, Amrit Puzari, Naresh A. Rajpurohit, Ramasamy Ramaraj, Isha Saini, Ahmed M. Salama, Zainab Shakoor, Paria Sharafi-Badr, Paul R. Shearing, Vinamrita Singh, Georgia Sourkouni, Lutfu S. Sua, R. Sujith, Mohammad Tabish, Soner Çakar, Ege Tini Tunca, Mahmut Özacar, Christos Vaitsis, Cédric Vancaeyzeele, Morena S. Xaba, Dharmendra Kumar Yadav, Prahlad Yadav, Ghulam Yasin, Luyi Zhou, Jian Zhu, Shuang Zong, and Antonis A. Zorpas

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2022
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39. Contributors

Author

Sharad Agarwal, Cristóbal N. Aguilar, Daisy Amaya-Chantaca, L. Amaya-Delgado, Md Nur Kabidul Azam, Roostita Lobo Balia, Sabyasachi Banerjee, Deepika Baranwal, Bikash Chandra Behera, Samuel Shiferaw Biresaw, Prativa Biswasroy, Sankhadip Bose, Yana Cahyana, Mónica L. Chávez-González, Monika Choudhary, Gabriel Contreras-Zarazua, Pooja Dange, Swagat Kumar Das, Pratik Dash, Supriya Dash, Júlio Cesar de Carvalho, Paulo Cesar de Souza Kirnev, Luciana Porto de Souza Vandenberghe, Rocío del Carmen Carranza-Méndez, Harisankar Dey, Subhasish Dutta, G. Flores-Cosío, Adriana C. Flores-Gallegos, Javier Fontalvo, J.A. García-Béjar, Goutam Ghosh, Angelo Gössi, Alok Kumar Gupta, Piyush K. Gupta, Md Nazmul Hasan, E.J. Herrera-López, Brenda Huerta-Rosas, Anna Iliná, Riya Jalan, Saurabh Kumar Jha, Sunanda Joshi, Vijay Juneja, null Kanupriya, Upasana Kapoor-Narula, Amia Khandker, Santimoy Khilari, Ankit Kumar, Neetu KumraTaneja, Mega Oktaviani Kurniawan, M. Láinez, Nibedita Lenka, Abhilasha S. Mathuriya, Rashmi Ranjan Mishra, Balaram Mohapatra, Sonali Mohapatra, Krishna Kumar Pandey, Soumya Pandit, Ami R. Patel, Manish Paul, Alan D. Pérez, Ashish Prabhu, Deepak Pradhan, Sahdeo Prasad, Juan José Quiroz-Ramirez, Rodolfo Ramos-González, Lavisha Rao, Goutam Rath, Wolfgang Riedl, Ana Gabriela Romero-García, Dibyajyoti Samantaray, Eduardo Sánchez-Ramírez, José Sandoval-Cortes, Nishit Savla, Boelo Schuur, Juan Gabriel Segovia-Hernández, Leonardo Sepúlveda-Torre, Tushar Ahmed Shishir, Shyamalini Shyamasuta, Anjani Sihag, Priya Singh, Smita Singh, Gauri Singhal, Carlos Ricardo Soccol, Prem Prakash Srivastav, Nidhi Srivastava, Saumya Srivastava, Mayank Taneja, Pankaj Taneja, Mamta Thakur, Hrudayanath Thatoi, Soubhagya Tripathy, Gemilang Lara Utama, Deepak Kumar Verma, Vartika Verma, and Belay Zeleke

Published
2022
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42. Contributors

Author

Arsalan Ahmed, Hammad Al-Shammari, Muhammad Fahad Arain, Vahid Beigi, Daniel Assumpção Bertuol, Amilton Barbosa Botelho Junior, Rebeca Mello Chaves, Jonghyun Choi, William Leonardo da Silva, Felipe M. de Souza, Denise Crocce Romano Espinosa, Siamak Farhad, Haiqiang Gong, Josep M. Guerrero, Ram K. Gupta, Congrui Jin, Alexandra Kaas, Arnavaz Keikavousi Behbahan, Muhammad Qamar Khan, Jae-chun Lee, Chan-Gi Lee, Shuya Lei, Jianlin Li, Ge Li, Tony Lyon, Thuany Maraschin, Thamiris Auxiliadora Gonçalves Martins, Seyyed Mohammad Mousavi, Thomas Mütze, Ashkan Namdar, Tannaz Naseri, Xing Ou, Leandro Rodrigues Oviedo, Ashwani Pandey, Soobhankar Pati, Sarthak Patnaik, Giovani Pavoski, Urs A. Peuker, Mauricio Dalla Costa Rodrigues da Silva, Malena T.L. Staudacher, Basudev Swain, Tian Tang, Gurleen Kaur Walia, Shunli Wang, Wei Wang, Denis Manuel Werner, Yanxin Xie, Rui Xu, Yue Yang, Long Ye, Jiafeng Zhang, and Ziwei Zhao

Published
2022
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48. List of contributors

Author

Abdalla M. Abdalla, Sumisha Anappara, Abul K. Azad, Suddhasatwa Basu, Ajit Behera, Tribani Boruah, Mohamed K. Dawood, Biswajit S. De, Sangeetha Dharmalingam, Anastasia Elias, Basem E. Elnaghi, Mohamed El-Sabahy, Qian Fu, Pablo A. García-Salaberri, Sonali Gautam, Nirali H. Gondaliya, Charu Goyal, Ram K. Gupta, Shahzad Hossain, Linbin Hu, Jayapriya Jayaprakash, Neeraj Khare, Haribabu Krishnan, Vaidhegi Kugarajah, Anuj Kumar, Dipak Kumar Das, Jun Li, Qiang Liao, Cauê A. Martins, Saranya Narayanasamy, Tuan Anh Nguyen, Fahimeh Hooriabad Saboor, Karthick Senthilkumar, Shabana P.S. Shaikh, John Solomon, Muhammad Rizwan Sulaiman, Shashank Sundriyal, Liang Zhang, Yunfeng Zhang, and Xun Zhu

Published
2022
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50. Mild and efficient one-pot synthesis of (E)-styrylperfluoroalkyl ketone from styrene

Author

V. Raghavender Rao, Kalpesh T. Patil, Deepak Kumar, Manoj K. Gupta, and Dong-Soo Shin

Subjects
Chemistry, Triflourooacetic anhydride, Heptafluoroacetic anhydride, General Chemistry, Pentafluorooacetic anhydride, (E)-Styrylperfluoroalkyl ketone, QD1-999, Styrene
Abstract

An easy and highly efficient one-pot synthesis of (E)-styrylperfluoroalkyl ketone from styrene using trifluoro-, pentafluoro-, heptafluoroacetic anhydride has been developed. This procedure mainly works on substituted styrene having electron donating groups which provide driving force to accelerate the reaction under base-free condition.

Published
2022

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