1. Analogs of 1α,25-Dihydroxyvitamin D3 in Clinical Use
- Author
-
Lori A. Plum and Hector F. DeLuca
- Subjects
0301 basic medicine ,1α 25 dihydroxyvitamin d ,Calcitriol ,business.industry ,Osteoporosis ,Biological activity ,Pharmacology ,medicine.disease ,Metabolic Bone Disorder ,03 medical and health sciences ,030104 developmental biology ,Vitamin D+Metabolites ,medicine ,Vitamin D and neurology ,Secondary hyperparathyroidism ,business ,medicine.drug - Abstract
Biologically active metabolites of vitamin D that have been successfully developed for the clinical market are described. Their properties that resulted in their success in the clinic are also provided. Precursors of the metabolically active 1α,25-dihydroxyvitamin D have been prepared and successfully marketed not only for renal failure patients but also for a variety of patients having metabolic bone disorders. Finally, successful analogs of 1α,25-dihydroxyvitamin D in use in the clinic worldwide are presented including properties that have contributed to their success.
- Published
- 2016
- Full Text
- View/download PDF