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3 results on '"šek"'

1. Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain

Author

David G. Wilkinson, Tania Seitanidou, Paula Murphy, M.A. Nieto, Patrick Charnay, Marie-Geneviève Mattei, Piotr Topilko, Nathalie Becker, and Pascale Gilardi-Hebenstreit

Subjects
Fetal Proteins, Telencephalon, Embryology, Mesoderm, animal structures, Molecular Sequence Data, Receptor Protein-Tyrosine Kinases, Rhombomere, Hindbrain, Cell Communication, Polymerase Chain Reaction, Receptor tyrosine kinase, Midbrain, Mice, Segmentation, medicine, Animals, Amino Acid Sequence, RNA, Messenger, Diencephalon, Tyrosine kinase, In Situ Hybridization, Genetics, Base Sequence, biology, Receptor, EphA4, Erythropoietin-producing hepatocellular (Eph) receptor, Chromosome Mapping, Neural crest, DNA, Cell biology, Rhombencephalon, Eph, medicine.anatomical_structure, Spinal Cord, Sek, embryonic structures, biology.protein, Developmental Biology
Abstract

15 páginas, 7 figuras., Pattern formation in the hindbrain involves a segmentation process leading to the formation of metameric units, manifested as successive swellings known as rhombomeres (r). In search for genes involved in cell-cell interactions during hindbrain segmentation, we have screened for protein kinase genes with restricted expression patterns in this region of the CNS. We present the cloning of three novel mouse genes, Sek-2, Sek-3 and Sek-4 (members of the Eph subfamily of putative transmembrane receptor protein tyrosine kinases (RTKs)), the identification of their chromosomal locations, and the analysis of their expression between 7.5 and 10.5 days of development. Before morphological segmentation, Sek-2 is transcribed in a transverse stripe corresponding to prospective r4 and the adjacent mesoderm, suggesting possible roles both in hindbrain segmentation and signalling between neuro-epithelium and mesoderm. Sek-3 and Sek-4 have common domains of expression, including r3, r5 and part of the midbrain, as well as specific domains in the diencephalon, telencephalon, spinal cord and in mesodermal and neural crest derivatives. Together with our previous finding that Sek (Sek-1) is expressed in r3 and r5 (Gilardi-Hebenstreit et al., 1992; Nieto et al., 1992), these data indicate that members of the Eph family of RTKs may co-operate in the segmental patterning of the hindbrain., This work was supported by grants from INSERM, CNRS, MRT, EEC, ARC, LNFCC, FRM and AFM. N. B. and P.M. were supported by fellowships from MRT and IFSBM, and HFSPO, respecitvely.

Published
1994

2. Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain

Author

Becker, Nathalie, Seitanidou, Tania, Murphy, Paula, Mattéi, Marie-Geneviève, Topilko, Piotr, Nieto, M. Ángela, Wilkinson, David G., Charnay, Patrick, Gilardi-Hebenstreit, Pascale, Becker, Nathalie, Seitanidou, Tania, Murphy, Paula, Mattéi, Marie-Geneviève, Topilko, Piotr, Nieto, M. Ángela, Wilkinson, David G., Charnay, Patrick, and Gilardi-Hebenstreit, Pascale

Abstract

Pattern formation in the hindbrain involves a segmentation process leading to the formation of metameric units, manifested as successive swellings known as rhombomeres (r). In search for genes involved in cell-cell interactions during hindbrain segmentation, we have screened for protein kinase genes with restricted expression patterns in this region of the CNS. We present the cloning of three novel mouse genes, Sek-2, Sek-3 and Sek-4 (members of the Eph subfamily of putative transmembrane receptor protein tyrosine kinases (RTKs)), the identification of their chromosomal locations, and the analysis of their expression between 7.5 and 10.5 days of development. Before morphological segmentation, Sek-2 is transcribed in a transverse stripe corresponding to prospective r4 and the adjacent mesoderm, suggesting possible roles both in hindbrain segmentation and signalling between neuro-epithelium and mesoderm. Sek-3 and Sek-4 have common domains of expression, including r3, r5 and part of the midbrain, as well as specific domains in the diencephalon, telencephalon, spinal cord and in mesodermal and neural crest derivatives. Together with our previous finding that Sek (Sek-1) is expressed in r3 and r5 (Gilardi-Hebenstreit et al., 1992; Nieto et al., 1992), these data indicate that members of the Eph family of RTKs may co-operate in the segmental patterning of the hindbrain.

Published
1994

3. Health economic costs of COPD in Sweden by disease severity--has it changed during a ten years period?

Author

Jansson SA, Backman H, Stenling A, Lindberg A, Rönmark E, and Lundbäck B

Subjects
Adult, Aged, Aged, 80 and over, Cost of Illness, Female, Health Care Costs trends, Humans, Male, Middle Aged, Prospective Studies, Pulmonary Disease, Chronic Obstructive epidemiology, Surveys and Questionnaires, Sweden epidemiology, Pulmonary Disease, Chronic Obstructive economics
Abstract

Objectives: The objectives of the presented study were to estimate societal costs of COPD in Sweden, the relationship between costs and disease severity, and possible changes in the costs during the last decade., Methods: Subjects with COPD derived from the general population in Northern Sweden were interviewed by telephone regarding their resource utilisation and productivity losses four times quarterly during 2009-10. Mean annual costs were estimated for each severity stage of COPD., Results: A strong relationship was found between disease severity and costs. Estimated mean annual costs per subject of mild, moderate, severe and very severe COPD amounted to 596 (SEK 5686), 3245 (SEK 30,957), 5686 (SEK 54,242), and 17,355 euros (SEK 165,569), respectively. The main cost drivers for direct costs were hospitalisations (for very severe COPD) and drugs (all other severity stages). The main cost driver for indirect costs was productivity loss due to sick-leave (for mild COPD) and early retirement (all other severity stages). Costs appeared to be lower in 2010 than in 1999 for subjects with severe and very severe COPD, but higher for those with mild and moderate COPD., Conclusion: Our results show that costs of COPD are strongly related to disease severity, and scaling the data to the whole Swedish population indicates that the total costs in Sweden amounted to 1.5 billion euros (SEK 13.9 bn) in 2010. In addition, costs have decreased since 1999 for subjects with severe and very severe COPD, but increased for those with mild and moderate COPD., (Copyright © 2013 Elsevier Ltd. All rights reserved.)

Published
2013
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