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1. THE FREQUENCY OF HLA-A, B AND DRB1 ALLELES IN PATIENTS WITH BETA THALASSEMIA

Author

Zeynep Karakas, Ayse Erol, Demet Kivanc, Mediha Suleymanoglu, Hayriye Senturk Ciftci, Cigdem Cinar, Serap Karaman, Mustafa Bilici, Aysegul Unuvar, Deniz Tugcu, Gulsah Tanyildiz, Fatma Savran Oguz, and Yasin Yilmaz

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Objective: HLA class I and II alleles are shown to be associated with certain diseases. A restricted numbers of alleles were found to be related to alloimmunisation in thalassemia population. The role of human leucocyte antigens in thalassemia is trend topic. In this study, the aim was to evaluate the differences in HLA frequencies of beta thalassemia patients comparing with healthy controls. Methodology: The data were collected of 100 patients who were diagnosed with beta thalassemia and 100 healthy controls were included in the study. The low resolution HLA-A, -B, -DRB1, tissue group data were performed Istanbul University, Faculty of Medicine, Medical Biology Department HLA typing laboratory. All data were analyzed retrospectively and their HLA allele frequencies were analyzed by SPSS (v22) program. Results: We found an increased frequency of HLA-B*14 (8% versus 2%) and HLA-B*52 (17% versus 2%) compared to the control group (p=0.05, OR=4.26; p

Published
2021
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2. THE FREQUENCY OF HLA-A, B AND DRB1 ALLELES IN PATIENTS WITH BETA THALASSEMIA

Author

Ayse Erol, Zeynep Karakas, Yasin Yilmaz, Hayriye Şentürk Çiftçi, Cigdem Kekik Cinar, Mustafa Bilici, Mediha Suleymanoglu, Deniz Tugcu, Gulsah Tanyildiz, Fatma Oguz, Demet Kivanc, Serap Karaman, and Ayşegül Ünüvar

Subjects
medicine.medical_specialty, education.field_of_study, Turkish population, congenital, hereditary, and neonatal diseases and abnormalities, business.industry, Thalassemia, Population, Beta thalassemia, Hematology, Human leukocyte antigen, medicine.disease, HLA-A, Internal medicine, hemic and lymphatic diseases, medicine, Immunology and Allergy, Diseases of the blood and blood-forming organs, Allele, RC633-647.5, business, education, Allele frequency
Abstract

Objective: HLA class I and II alleles are shown to be associated with certain diseases. A restricted numbers of alleles were found to be related to alloimmunisation in thalassemia population. The role of human leucocyte antigens in thalassemia is trend topic. In this study, the aim was to evaluate the differences in HLA frequencies of beta thalassemia patients comparing with healthy controls. Methodology: The data were collected of 100 patients who were diagnosed with beta thalassemia and 100 healthy controls were included in the study. The low resolution HLA-A, -B, -DRB1, tissue group data were performed Istanbul University, Faculty of Medicine, Medical Biology Department HLA typing laboratory. All data were analyzed retrospectively and their HLA allele frequencies were analyzed by SPSS (v22) program. Results: We found an increased frequency of HLA-B*14 (8% versus 2%) and HLA-B*52 (17% versus 2%) compared to the control group (p=0.05, OR=4.26; p

Published
2021

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