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1. Cell contact dependent extended release of adenovirus by microparticles in vitro.

Author

Cavanagh HM, Dingwall D, Steel J, Benson J, and Burton M

Subjects
Adenoviruses, Human immunology, Cell Line, Humans, Tumor Cells, Cultured, Adenoviruses, Human physiology
Abstract

Adenoviral vectors remain one of the most promising methods of gene delivery but are plagued by several inherent problems including immune inactivation and transient expression. This paper reports a novel microparticle-based delivery system for adenovirus that allows high uptake of virus, stable complex formation and extended release. In addition, this microparticle/adenovirus complex has been demonstrated to only release virus upon cell contact. The significant clinical implications of this delivery system are discussed.

Published
2001
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