1. The effects of norepinephrine depletion on cerebral blood flow in the rat.
- Author
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Onesti ST, Strauss RC, Mayol B, and Solomon RA
- Subjects
- Animals, Butanols metabolism, Cerebral Cortex drug effects, Cerebral Cortex physiology, Cerebral Ventricles drug effects, Cerebral Ventricles physiology, Functional Laterality, Hydroxydopamines pharmacology, Male, Oxidopamine, Pargyline pharmacology, Rats, Rats, Inbred Strains, Reference Values, Cerebrovascular Circulation drug effects, Dopamine physiology, Norepinephrine physiology
- Abstract
Cerebral blood flow (CBF) was measured by [14C]butanol indicator fractionation in 10 rats given intraventricular injections of 6-hydroxydopamine (6-OHDA) compared to 8 saline-injected controls. Rats treated with 6-OHDA displayed an 83% reduction in cortical norepinephrine (NE) levels. CBF was significantly increased in 6-OHDA-treated rats compared to controls (average whole brain blood flow of 126.0 +/- 8.3 and 97.1 +/- 10.6 ml.min-1.10(-2)g-1 respectively, P less than 0.05). These studies suggest that noradrenergic innervation of the brain and cerebral microvasculature exerts a moderating effect on resting CBF.
- Published
- 1989
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