1. Maternal protein malnutrition prolongs sickness behavior in male offspring.
- Author
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Batista TH, Ribeiro ACAF, Kalil B, Giusti-Paiva A, and Vilela FC
- Subjects
- Animals, Corticosterone blood, Endotoxemia blood, Endotoxemia psychology, Female, Fever etiology, Lactation, Lipopolysaccharides toxicity, Male, Pregnancy, Rats, Rats, Wistar, Social Behavior, Swimming, Tumor Necrosis Factor-alpha blood, Illness Behavior, Pregnancy Complications physiopathology, Prenatal Exposure Delayed Effects, Protein Deficiency physiopathology
- Abstract
Female rats were fed a normal or hypoproteic diet during the phases of gestation and lactation. The male offspring of these rats were grown to adulthood and used to study the effects of maternal protein malnutrition on progeny. The adult male rats were pretreated with either saline or LPS and subjected to behavioral tests 2 and 6 h after administration. Tumor necrosis factor (TNF-α), corticosterone and body temperature were the parameters used for assessment. Two hours after LPS administration, sickness behavior was developed in all the animals, regardless of maternal protein malnutrition. After 6 h of LPS administration, sickness behavior was more pronounced in the rats that had been subjected to maternal protein malnutrition. Only the rats with maternal protein malnutrition expressed an increase in the plasma levels of TNF-α and corticosterone. Maternal protein malnutrition prolongs sickness behaviors in offspring., Competing Interests: Declaration of Competing Interest The authors report no biomedical financial interests or other potential conflicts of interest., (Copyright © 2020. Published by Elsevier B.V.)
- Published
- 2020
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