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Start Over Author "McGee NR" Publisher elsevier/north-holland
3 results on '"McGee NR"'

1. Relation of intrathecal oligoclonal band production to inflammatory mediator and immunotherapy response in 208 children with OMS.

Author

Pranzatelli MR, McGee NR, and Tate ED

Subjects
Biomarkers blood, Biomarkers cerebrospinal fluid, Case-Control Studies, Child, Child, Preschool, Cohort Studies, Female, Humans, Immunologic Factors blood, Immunologic Factors cerebrospinal fluid, Male, Opsoclonus-Myoclonus Syndrome drug therapy, Retrospective Studies, Treatment Outcome, Immunotherapy methods, Inflammation Mediators blood, Inflammation Mediators cerebrospinal fluid, Oligoclonal Bands blood, Oligoclonal Bands cerebrospinal fluid, Opsoclonus-Myoclonus Syndrome blood, Opsoclonus-Myoclonus Syndrome cerebrospinal fluid
Abstract

In 208 children with opsoclonus-myoclonus syndrome (OMS), CSF IgG oligoclonal bands (OCB) and 22 immunomarkers in CSF and 21 in serum/blood were measured. In 36 untreated OMS, 58% were OCB(+), whereas 55% of treated OMS were OCB(-). OCB positivity or negativity did not alter concentrations or frequencies of immunomarkers. The phenotypes of OCB(+) and OCB(-) patients were not distinctive. CSF B cells were expanded in untreated OMS regardless of OCB positivity. These data reveal a much higher frequency of OCB positivity in untreated OMS than previously realized and a disconnect between intrathecal OCB and inflammatory mediator production., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2018
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2. CSF neurofilament light chain is elevated in OMS (decreasing with immunotherapy) and other pediatric neuroinflammatory disorders.

Author

Pranzatelli MR, Tate ED, McGee NR, and Verhulst SJ

Subjects
Adolescent, Adrenocorticotropic Hormone therapeutic use, Adult, Antibodies, Monoclonal, Murine-Derived therapeutic use, Child, Child, Preschool, Cross-Sectional Studies, Cytokines metabolism, Female, Humans, Immunoglobulins, Intravenous therapeutic use, Immunologic Factors therapeutic use, Male, Observation, Retrospective Studies, Rituximab, Severity of Illness Index, Young Adult, Encephalitis cerebrospinal fluid, Neurofilament Proteins cerebrospinal fluid, Opsoclonus-Myoclonus Syndrome cerebrospinal fluid
Abstract

Using a panel of seven brain cell-specific biomarkers in cerebrospinal fluid (CSF), pediatric opsoclonus-myoclonus syndrome (OMS) (n=234) was compared to pediatric non-inflammatory neurological controls (n=84) and other inflammatory neurological disorders (OIND) (n=44). Only CSF NFL was elevated in untreated OMS versus controls (+83%). It was 87% higher in OIND than in OMS. On combination treatment with front-loaded ACTH, IVIg, rituximab, median CSF NFL decreased by 60% to control levels. These biochemical data suggest neuronal/axonal injury in some children with OMS without indicators of astrogliosis, and reduction on sufficient immunotherapy., (Copyright © 2013 Elsevier B.V. All rights reserved.)

Published
2014
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3. Key role of CXCL13/CXCR5 axis for cerebrospinal fluid B cell recruitment in pediatric OMS.

Author

Pranzatelli MR, Tate ED, McGee NR, Travelstead AL, Ransohoff RM, Ness JM, and Colliver JA

Subjects
Adolescent, Adrenal Cortex Hormones therapeutic use, Adrenocorticotropic Hormone pharmacology, Adrenocorticotropic Hormone therapeutic use, Analysis of Variance, Antigens, CD metabolism, B-Lymphocytes drug effects, Case-Control Studies, Cell Movement drug effects, Chemokine CXCL12 cerebrospinal fluid, Chemokine CXCL12 metabolism, Chemokine CXCL13 cerebrospinal fluid, Child, Child, Preschool, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Humans, Immunoglobulins, Intravenous therapeutic use, Infant, Longitudinal Studies, Male, Opsoclonus-Myoclonus Syndrome drug therapy, B-Lymphocytes metabolism, Chemokine CXCL13 metabolism, Opsoclonus-Myoclonus Syndrome cerebrospinal fluid, Receptors, CXCR5 metabolism
Abstract

To study aberrant B cell trafficking into the CSF in opsoclonus-myoclonus syndrome (OMS), chemoattractants CXCL13 and CXCL12, and B cell frequency and CXCR5 expression, were evaluated. CSF CXCL13 concentration and the CSF/serum ratio were higher in untreated OMS than controls, related directly to OMS severity and inversely to OMS duration, and correlated with CSF B cell frequency and oligoclonal bands. CXCL12 showed the opposite pattern. Selective accumulation of CXCR5+ memory B cells in CSF was found. In ACTH-treated OMS, CXCL13, but not CXCL12, was lower. These data implicate the chemokine/chemoreceptor pair CXCL13/CXR5 in B cell recruitment to the CNS in OMS. CXCL13 and CXCL12 may serve as reciprocal biomarkers of disease activity, but CXCL13 also had utility as a treatment biomarker., (Copyright © 2011 Elsevier B.V. All rights reserved.)

Published
2012
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