1. Primary macroglobulinemia with t(11;18)(q21;q21).
- Author
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Hirase N, Yufu Y, Abe Y, Muta K, Shiokawa S, Nawata H, and Nishimura J
- Subjects
- Aged, Female, Humans, Immunophenotyping, Karyotyping, Male, Middle Aged, Polymorphism, Single-Stranded Conformational, Proto-Oncogene Proteins genetics, Proto-Oncogene Proteins c-bcl-2 genetics, Proto-Oncogene Proteins c-yes, Reverse Transcriptase Polymerase Chain Reaction, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 18, Lymphoma, B-Cell genetics, Translocation, Genetic, Waldenstrom Macroglobulinemia genetics, src-Family Kinases
- Abstract
These are the first cases of primary macroglobulinemia (PMG) with t(11;18)(q21;q21) reported in the literature. The first case was a 77-year-old man with macroglobulinemia (serum IgM: 8.36 g/dL). Abnormal lymphoid cells were detected in the blood and bone marrow. Immunologic and karyotypic analyses revealed that abnormal cells were positive for surface IgM-k, CD19, and CD20, negative for CD5 and CD10, and all had a t(11;18)(q21;q21). The second case was a 57-year-old woman with macroglobulinemia (serum IgM: 12.0 g/dL). Abnormal lymphoid cells were detected in blood and marrow, and cells were positive for surface IgM-lambda, CD19, and CD20, and negative for CD5 and CD10. Plasma cells bearing cytoplasmic IgM-lambda were increased in pleural fluid. Karyotyping demonstrated t(2;11;18)(q21-23;q21;q21). Rearrangements within BCL2 and YES genes located at 18q21 were not detected. Sixteen other cases with t(11;18)(q21;q21) have been reported in marginal zone B-cell lymphoma. Therefore, our report is in agreement with the finding that part of primary macroglobulinemia is a variant of marginal zone B-cell lymphoma.
- Published
- 2000
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