1. Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis.
- Author
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Cameron EM, Spencer S, Lazarini J, Harp CT, Ward ES, Burgoon M, Owens GP, Racke MK, Bennett JL, Frohman EM, and Monson NL
- Subjects
- Amino Acid Sequence genetics, Antibodies analysis, Antibodies cerebrospinal fluid, Autoantibodies analysis, Autoantibodies cerebrospinal fluid, Autoantibodies genetics, B-Lymphocytes metabolism, Biomarkers analysis, Biomarkers cerebrospinal fluid, Databases, Genetic, Diagnostic Techniques, Neurological, Disease Progression, Genetic Markers genetics, Genetic Markers immunology, Humans, Immunoglobulins analysis, Immunoglobulins cerebrospinal fluid, Immunoglobulins genetics, Molecular Biology methods, Multiple Sclerosis diagnosis, Proteome, Sequence Alignment, Antibodies genetics, B-Lymphocytes immunology, Genes genetics, Multiple Sclerosis genetics, Multiple Sclerosis immunology, Mutation genetics
- Abstract
We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.
- Published
- 2009
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