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Objectives: Advances in science and technology have meant there are numerous treatment options available for people with advanced breast cancer (ABC). However, each therapeutic approach can cause side effects or adverse events, which can significantly affect the person's quality of life, overall well-being, and, in some instances, safety. This report presents an overview of the common side effects of systemic anticancer therapy and ways to manage them., Data Sources: Data sources include peer-reviewed articles sourced in electronic databases and national and international best practice guidelines (ESMO, ASCO, and MASCC guidelines)., Conclusion: Systemic anticancer therapies have side effects that healthcare professionals need to know about to monitor and manage them in early stages. Nurses play an important role in patient education, early identification, monitoring, and management of treatment side effects., Implications for Nursing Practice: People with ABC face many challenges during their treatment journey. Oncology nurses, specialist nurses, and nurse practitioners can be of support by providing preventive measures and side effects management at an early stage. Nurses need to have a good understanding of toxicity management but also advanced tumor-specific cancer knowledge of the different subtypes of ABC and holistic assessment skills. They are also key to providing support and enhancing self-management and early recognition of side effects., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Celia Diez de los Rios and Theresa Wiseman were Guest Editors for the Metastatic Breast Cancer Special Issue of Seminars in Oncology Nursing. As an author of this article, they did not participate in any editorial process or decision-making, which was handled by another editor., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)

Objectives: To provide background information and management strategies for non-rash dermatological adverse events., Data Sources: Peer-reviewed journal articles, professional manuals, online sources., Conclusion: During the last decade, many dermatological adverse events of targeted therapy have been reported, including xerosis, skin fissures, pruritus, photosensitivity, pigmentation changes, hair and nail changes, hand-foot skin reaction, squamoproliferative lesions, Stevens-Johnsons syndrome, and toxic epidermal necrolysis. Although evidenced-based treatment options are scarce, many recommendations have been described in the literature that should be considered to apply in daily practice., Implications for Nursing Practice: Nursing practice will be enhanced by education, assessment, and management recommendations., (Copyright © 2014 Elsevier Inc. All rights reserved.)