1. A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.
- Author
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Bo Li, Jiapeng Hou, Yuwei Yao, Xiaotian Cui, Xiaoli Sun, Boxun Lu, Al-Ramahi, Ismael, Botas, Juan, Difiglia, Marian, Palacino, James, Zhi-Ying Wu, and Lixiang Ma
- Subjects
HUNTINGTON disease ,G protein coupled receptors ,NEURODEGENERATION ,HUNTINGTIN protein ,NEOSTRIATUM ,PREVENTION - Abstract
The article discusses a report about the striatal enriched G protein coupled receptor (GPCR) to act as a stabilizer of huntington's disease (HD) which is a neuro-degenerative disorder. It also focuses on the causes of HD which is cytotoxicity of mutant Htt (huntington) protein (mHtt) in the brain & peripheral tissues. In addition a selective vulnerability of the striatal neurons was found for the striatal enriched modulation of the Htt protein levels.
- Published
- 2015
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