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Start Over Author "Yiming Chang" Publisher elife sciences publications, ltd.
3 results on '"Yiming Chang"'

3. A non-canonical mechanism for Crm1-export cargo complex assembly.

Author

Fischer, Ute, Schäuble, Nico, Yiming Chang, Boulos Faza, Marius, Govind Panse, Vikram, Schütz, Sabina, and Altvater, Martin

Subjects
CHROMOSOMES, PROTEIN binding, RIBOSOMAL proteins, NUCLEAR nonproliferation, XENOPUS
Abstract

The article discusses a possible solution to the problem that Rapid Crm1-meditated export is also weakly binding, which makes it less than ideal for transport of diverse cargos. The solution involves Slx9, a new type of RanGTP-binding protein. Slx9, when delivered in vitro, binds Rio2 and RanGTP, and forms a complex that can directly load Crm1. Slx9 acts as a support structure for RanGTP and NES with regard to Crm1 and causes export of 40S pre-ribosome.

Published
2015
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