1. Circuits that encode and guide alcohol-associated preference
- Author
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Mustafa Talay, Sydney Gang, Gilad Barnea, Kavin M Nunez, Sarah Salamon, Amanda G Waterman, Sophia L. Song, Karla R. Kaun, and Kristin M. Scaplen
- Subjects
Male ,QH301-705.5 ,Science ,fan-shaped body ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Arousal ,memory ,Glutamatergic ,Reward ,Dopamine ,Biological neural network ,medicine ,Animals ,Biology (General) ,Mushroom Bodies ,Adaptive memory ,Ethanol ,D. melanogaster ,General Immunology and Microbiology ,alcohol ,Dopaminergic Neurons ,General Neuroscience ,Dopaminergic ,General Medicine ,mushroom body ,Drosophila melanogaster ,nervous system ,Synapses ,Mushroom bodies ,Medicine ,Female ,Drosophila ,Memory consolidation ,Nerve Net ,dopamine ,Neuroscience ,Research Article ,medicine.drug - Abstract
A powerful feature of adaptive memory is its inherent flexibility. Alcohol and other addictive substances can remold neural circuits important for memory to reduce this flexibility. However, the mechanism through which pertinent circuits are selected and shaped remains unclear. We show that circuits required for alcohol-associated preference shift from population level dopaminergic activation to select dopamine neurons that predict behavioral choice inDrosophila melanogaster. During memory expression, subsets of dopamine neurons directly and indirectly modulate the activity of interconnected glutamatergic and cholinergic mushroom body output neurons (MBON). Transsynaptic tracing of neurons important for memory expression revealed a convergent center of memory consolidation within the mushroom body (MB) implicated in arousal, and a structure outside the MB implicated in integration of naïve and learned responses. These findings provide a circuit framework through which dopamine neuronal activation shifts from reward delivery to cue onset, and provide insight into the maladaptive nature of memory.
- Published
- 2020
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