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Your search keyword '"Cherasse, Yoan"' showing total 7 results
Start Over Author "Cherasse, Yoan" Publisher elife sciences publications, ltd
7 results on '"Cherasse, Yoan"'

1. Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release

Author

Heather A. Sullivan, Ya-Dong Li, Hechen Bao, Ian R. Wickersham, Yen-Yu Ian Shih, Luis Quintanilla, Cherasse Yoan, Michael Lazarus, Yan-Jia Luo, and Juan Song

Subjects
Male, 0301 basic medicine, Hypothalamus, Posterior, Mouse, Vesicular Inhibitory Amino Acid Transport Proteins, QH301-705.5, Science, Glutamic Acid, Biology, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Calcium imaging, fiber photometry, Animals, memory retrieval, Calcium Signaling, Biology (General), Maze Learning, Spatial Memory, memory encoding, General Immunology and Microbiology, General Neuroscience, Dentate gyrus, Glutamate receptor, General Medicine, Mice, Inbred C57BL, calcium imaging, 030104 developmental biology, Transmission (telecommunications), Dentate Gyrus, SuM-DG correlation, Medicine, Female, SuM glutamate transmission, Neuroscience, 030217 neurology & neurosurgery, Supramammillary Nucleus, Research Article
Abstract

The supramammillary nucleus (SuM) provides substantial innervation to the dentate gyrus (DG). It remains unknown how the SuM and DG coordinate their activities at the circuit level to regulate spatial memory. Additionally, SuM co-releases GABA and glutamate to the DG, but the relative role of GABA versus glutamate in regulating spatial memory remains unknown. Here we report that SuM-DG Ca2+ activities are highly correlated during spatial memory retrieval as compared to the moderate correlation during memory encoding when mice are performing a location discrimination task. Supporting this evidence, we demonstrate that the activity of SuM neurons or SuM-DG projections is required for spatial memory retrieval. Furthermore, we show that SuM glutamate transmission is necessary for both spatial memory retrieval and highly-correlated SuM-DG activities during spatial memory retrieval. Our studies identify a long-range SuM-DG circuit linking two highly correlated subcortical regions to regulate spatial memory retrieval through SuM glutamate release.

Published
2020
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4. Author response: Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus

Author

Yuan, Xiang-Shan, primary, Wang, Lu, additional, Dong, Hui, additional, Qu, Wei-Min, additional, Yang, Su-Rong, additional, Cherasse, Yoan, additional, Lazarus, Michael, additional, Schiffmann, Serge N, additional, d'Exaerde, Alban de Kerchove, additional, Li, Rui-Xi, additional, and Huang, Zhi-Li, additional

Published
2017
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7. Striatal adenosine A 2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus.

Author

Yuan XS, Wang L, Dong H, Qu WM, Yang SR, Cherasse Y, Lazarus M, Schiffmann SN, d'Exaerde AK, Li RX, and Huang ZL

Subjects
Adenosine metabolism, Animals, Brain Mapping, Male, Mice, Microscopy, Immunoelectron, Neurons chemistry, Globus Pallidus physiology, Neostriatum physiology, Neurons physiology, Parvalbumins analysis, Receptor, Adenosine A2A analysis, Sleep, Wakefulness
Abstract

Dysfunction of the striatum is frequently associated with sleep disturbances. However, its role in sleep-wake regulation has been paid little attention even though the striatum densely expresses adenosine A 2A receptors (A 2A Rs), which are essential for adenosine-induced sleep. Here we showed that chemogenetic activation of A 2A R neurons in specific subregions of the striatum induced a remarkable increase in non-rapid eye movement (NREM) sleep. Anatomical mapping and immunoelectron microscopy revealed that striatal A 2A R neurons innervated the external globus pallidus (GPe) in a topographically organized manner and preferentially formed inhibitory synapses with GPe parvalbumin (PV) neurons. Moreover, lesions of GPe PV neurons abolished the sleep-promoting effect of striatal A 2A R neurons. In addition, chemogenetic inhibition of striatal A 2A R neurons led to a significant decrease of NREM sleep at active period, but not inactive period of mice. These findings reveal a prominent contribution of striatal A 2A R neuron/GPe PV neuron circuit in sleep control.

Published
2017
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