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The present study was designed to evaluate the suspected anticancer activity of Solenostemma argel (200 mg/kg body weight/ day) either alone or combined with cisplatin (0.64 mg/kg body weight/day) for 4 weeks against lung cancer induced by DMBA (20 mg/kg bw) for 8 weeks in male Wistar rats.At the end of experiment, blood and Lung samples were collected to assess biochemical and biophysical markers as well histopathological investigations. Biochemical parameters:, serum Tumor suppressor protein (P53) and (P16), Transforming Growth Factor-beta (TGF-β), interleukin-1beta (IL-1β), interleukin-6 (IL-6), Carcino Embryonic antigen (CEA). Lung induced nitric oxide synthase (i-Nos), cyclin dependent kinase-2 (CDK2). The level of significance between mean values was set at p < 0.05. The results of this study also showed that administration of olenostemma argel to lung carcinoma induced rats demonstrated a significant improvement in biochemical parameters and life span as compared to DMBA control rats. The histopathological examinations of this study revealed damage and degeneration in the lung of DMBA treated rats. Also, lung of Argel and Cisplatin rats showed significant improvement and protection against DMBA harmful effect.

The present study was designed to elucidate the protective effect of subsequent pretreatment withFructus Piperis Longi extract in liver and brain tissue of experimental rats exposed to Hepaticencephalopathy induced by intraperitoneal administration of TAA. Plf extract (50 mg/kg) was force-fedto rats every day, 7 days before administration of Thioacetamide. Thioacetamide 200 mg/kg wasintraperitoneally administered to rats twice per week for four weeks. Administration of Plfext wasextended during Thioacetamide. After 4 weeks, animals were sacrificed. Biochemical parameters inserum and homogenized liver and brain were tested. A significant increase in serum transglutaminase,alkaline phosphatase and gamma glutamyl transferase activity and plasma ammonia, a significantdecrease in serum albumin and total protein was recorded in the liver of Thioacetamide-treated rats.Significant increases in liver and brain lipid peroxides associated to significant decreases of liver andbrain reduced glutathione concentration and catalase activities were also recorded. Administration ofPlfext treatment reduced the severity of liver fibrosis and oxidative damage which was substantiated byimprovement of liver function detected by a decrease in serum aspartate amino transaminase, alanineaminotransferase, alkaline phosphatase, gamma glutamyl transferase activities and increase in totalprotein and Albumin. It was concluded that treatment of the ethanolic extract of Fructus Piperis Longienhance Liver and brain parameter and enhanced antioxidant activities of liver and brain.