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With the vigorous advancement of China’s medical reform and the continuous improvement of medical services, hospitals are increasingly demanding and relying on informatization. It can be said that informatization covers all aspects of hospital business and provide comprehensive, efficient, convenient and automated management and services for the normal operation of the hospital. At present, hospitals have gradually increased their investment in informatization, and the upgrading and transformation of informatization has also been continuously enhanced. However, there are still a large number of problems in the application of hospital informatization management. It is necessary for hospital informatization managers and executors to face relevant problems,understand the tasks and goals of the next stage of hospital informatization development. This paper mainly expounds the development status of hospital information system, lists the common problems in the application of hospital informatization, puts forward reasonable and effective informatization construction methods and strategies, and points out that the construction of integrated platform hospital data warehouse and health care cloud platform is the future development direction of hospital informatization.