1. The synergistic effect of the combination of Ocimum basilicum and Ceratonia siliqua on inflammation and oxidative stress
- Author
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Touiss Ilham, Khaili Aymane, Khouya Tarik, Bekkouch Oussama, Harnafi Mohamed, Lahmass Iliass, Alem Chakib, Amrani Souliman, and Harnafi Hicham
- Subjects
ocimum basilicum ,rosmarinic acid ,carob ,inflammation ,lipid oxidation ,Environmental sciences ,GE1-350 - Abstract
The use of basil and carob in traditional medicine to address inflammation and oxidative stress reflects a long-standing practice rooted in folk medicine. This study was conducted to demonstrate the anti-inflammatory and antioxidant properties of a rosmarinic acid-rich extract of Ocimum basilicum (RAE) combined with a carob aqueous extract (CAE). Paw edema in rats and vascular permeability in mice were measured to investigate the anti-inflammatory effect. The assessment of lipoprotein oxidation was carried out by measuring thiobarbituric acid reactive substances as well as determining the scavenging activity towards lipoperoxyl radicals and 2,2-diphenyl-1-picrylhydrazyl (DPPH). The combination (200 mg/kg) significantly decreased carrageenan-induced rat paw edema and vascular permeability in mice (p
- Published
- 2024
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