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The road is an access that connects one place to another in one land. According to Law Number 38 of 2004 concerning roads, the definition of a road is a land transportation infrastructure which includes all parts of the road including auxiliary buildings and equipment. But it often happens that road construction is not accompanied by good maintenance, giving rise to various kinds of problems. One of the road damages that occurred in Indonesia was caused by standing water on the road surface. This is because Indonesia has a high level of rainfall. Therefore, the use of porous asphalt as a road surface layer can be used as an effort to deal with this problem. The use of steel slag waste material is to reduce the use of natural aggregates and to reduce B3 waste, which is increasing day by day. In this study, the coarse aggregate retained on the 3/8" and No. 4 filters in the porous asphalt mixture was replaced with steel slag aggregate with variations of 0%, 25%, 50%, 75% and 100% with variations in asphalt content of 5%, 5, 5%,6%, 6.5% and 7%. The purpose of this study was to determine the effect of using steel slag waste on the stability level of porous asphalt pavements. The specification used in this study is the Australian Asphalt Pavement Association (2004). The results of the research that has been done, it shows that the use of steel slag as a substitute for coarse aggregate is retained by the 3/8" and No. 4 on porous asphalt mixtures can increase the stability value of porous asphalt for all variations in existing asphalt content.

Colistin is a decapeptide antibiotic with narrow spectrum activity, mainly used as treatment for Gram negative bacteria. This study aims to scientifically determine the effect of colistin administration as medicated feed on alanine aminotransferase (ALT) and creatinine level in broiler infected with Escherichia coli. KTOP group as positive control, KTON group as negative control, while I, II, and III groups were infected with Escherichia coli 1 x 108 CFU/ml 0.1 ml via intratracheal route. Group I, II, and III were given colistin treatment dosage of 0.3 g/kg food, 0.6 g/kg food, and 1.2 g/kg food. Blood samples were taken through brachial veins for ALT and creatinine examination with a Caretium NB-201 semi-auto chemistry analyzer. Data were examined statistically using IBM SPSS Statistics 24 software and graphically using Microsoft Excel 365. Conclusion of the research by statistical analysis with Kruskal-Wallis test obtained ALT test results P = 0.147 and creatinine test results P = 0.815. Based on the results of this study, the administration of colistin medicated feed did not cause a significant effect on ALT and creatinine level in broiler infected with Escherichia coli, indicating that colistin has low potential toxicity while given as medicated feed.