1. In vivo oxidation of carboxyl-labelled cyclic fatty acids formed from linoleic and linolenic acids in the rat
- Author
-
Florent Joffre, Jean-Pierre Sergiel, Alexandre Roy, Bruno Pasquis, Jean-Louis Sébédio, Lionel Bretillon, Olivier Loreau, Jean-Michel Chardigny, Unité mixte de recherche nutrition lipidique et régulation fonctionnelle du coeur et des vaisseaux, Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11), and ProdInra, Migration
- Subjects
Male ,Embryology ,oxidation ,030309 nutrition & dietetics ,Linolenic acid ,Linoleic acid ,Administration, Oral ,Medicine (miscellaneous) ,essential fatty acids ,Biology ,Linoleic Acid ,03 medical and health sciences ,chemistry.chemical_compound ,In vivo ,heating oil ,Animals ,Tissue Distribution ,[SDV.SA.SPA] Life Sciences [q-bio]/Agricultural sciences/Animal production studies ,Carbon Radioisotopes ,Rats, Wistar ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,ComputingMilieux_MISCELLANEOUS ,Unsaturated fatty acid ,chemistry.chemical_classification ,0303 health sciences ,0402 animal and dairy science ,alpha-Linolenic Acid ,Fatty acid ,[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology ,04 agricultural and veterinary sciences ,Metabolism ,Carbon Dioxide ,040201 dairy & animal science ,Rats ,Monomer ,Reproductive Medicine ,chemistry ,Biochemistry ,Organ Specificity ,[SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies ,Fatty Acids, Unsaturated ,RAT ,Animal Science and Zoology ,Oxidation-Reduction ,metabolism ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Developmental Biology ,Food Science ,Polyunsaturated fatty acid - Abstract
Cyclic fatty acid monomers (CFAM), which occur from the intramolecular cyclisation of linoleic and linolenic acids, are subsequently present in some edible oils and are suspected to induce metabolic disorders. One may suggest that the presence of a ring would alter the ability of the organism to oxidise these molecules. In order to test this hypothesis, we assessed the oxidative metabolism of CFAM in rats. For this purpose, rats were force-fed from 1.5 to 2.6 MBq of (1- 14 C)- linoleic acid, (1- 14 C)-linolenic acid, (1- 14 C)-CFAM-18:2 or (1- 14 C)-CFAM-18:3, and 14 CO2 production was monitored for 24h. The animals were then sacrificed and the radioactivity was determined in different tissues. No significant differences in 14CO 2 production were found 24h after the administration of CFAM and their respective precursors. Our data clearly demonstrate that, at least for the first β-oxidation cycle, CFAM are oxidised in a similar way as both essential fatty acids. heating oil / essential fatty acids / oxidation / metabolism
- Published
- 2004