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Gastric juice proteins were studied in normal subjects and persons with gastro-intestinal, lung and pancreatic neoplasia and chronic systemic lymphopathy and haemoblastosis, using cellulose acetate and acrylamide gel electrophoresis of the freeze-dried dialyaste and chromatography of the amino acids obtained from the hydrolysate. Definite evidence was gathered of both qualitative and quantitative changes in protein fractions. Patterns varied from one group of subjects to another, though the basic picture was the same in both intestinal and extra-intestinal conditions. An effective relationship between the diseases considered is postulated and the data are interpreted with a view to evolving other points for further investigation.

Membrane proteins in circulating blood cells were examined in chick embryos on the 4th, 5th, 6th, 7th and 10th incubation day, in chicks immediately after hatching, and in adult birds. Haemoglobin electrophoresis patterns were determined on cellulose acetate after solubilisation with urea, and in gradient of pH and concentration on acrylamide gels after solubilisation in SDS. Amino acids and other amino compounds were also determined after acid hydrolysis and resin chromatography. Haemoglobin patterns were similar to those displayed by the membrane proteins. The latter, however, changed more slowly.