1. Periodontitis and the microbiome: a systematic review and meta-analysis
- Author
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Giuseppe La Torre, Denise Corridore, Artnora Ndokaj, Antonella Polimeni, Marta Mazur, Fabrizio Guerra, and Livia Ottolenghi
- Subjects
0301 basic medicine ,medicine.medical_specialty ,MEDLINE ,periodontitis ,microbiome ,systematic review ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Microbiome ,Periodontitis ,biology ,business.industry ,Microbiota ,Aggregatibacter actinomycetemcomitans ,030206 dentistry ,Odds ratio ,medicine.disease ,biology.organism_classification ,Confidence interval ,030104 developmental biology ,Otorhinolaryngology ,Meta-analysis ,Surgery ,Oral Microbiome ,Oral Surgery ,business - Abstract
INTRODUCTION The association between the oral microbiome and periodontal diseases is still unclear. We performed a systematic review and meta-analysis to quantify the association between the specific pathogens and periodontitis. EVIDENCE ACQUISITION A computerized medical search was performed using MEDLINE and SCOPUS database between 1950 and May 2017 to identify all case-control studies that evaluated the association between specific pathogens and periodontitis. The pooled Odds Ratio with relative 95% confidence interval (95% CI) was calculated and plotted in the forest plot. EVIDENCE SYNTHESIS Eleven RCTs involving 2111 patients were included. The retrieved case-control studies evaluated the presence or absence of different targeted pathogens. Among the microrganisms evaluated Porphyromonas gengivalis (OR [95% CI] 2.93 [0.98,8.87]; P
- Published
- 2018