1. Clinical efficacy of intravenous colistin therapy in combination with ceftazidime in severe MDR P. aeruginosa systemic infections in two haematological patients.
- Author
-
Tascini C, Menichetti F, Stefanelli A, Loni C, and Lambelet P
- Subjects
- Acute Disease, Adrenal Cortex Hormones adverse effects, Adrenal Cortex Hormones therapeutic use, Aged, Anemia, Refractory, with Excess of Blasts complications, Anti-Bacterial Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Bacteremia etiology, Ceftazidime administration & dosage, Colistin administration & dosage, Colitis etiology, Colitis surgery, Disease Susceptibility, Drug Resistance, Multiple, Bacterial, Drug Therapy, Combination, Fatal Outcome, Female, Humans, Infusions, Intravenous, Leukemia, Myeloid drug therapy, Lymphoma, Non-Hodgkin drug therapy, Lymphoma, Non-Hodgkin radiotherapy, Male, Middle Aged, Neoplasms, Second Primary complications, Peritonitis etiology, Postoperative Complications etiology, Postoperative Complications microbiology, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy, Pseudomonas Infections etiology, Radiation Injuries etiology, Radiation Injuries surgery, Spinal Neoplasms drug therapy, Spinal Neoplasms radiotherapy, Typhlitis complications, Bacteremia drug therapy, Ceftazidime therapeutic use, Colistin therapeutic use, Leukemia, Myeloid complications, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications, Pseudomonas Infections drug therapy
- Abstract
Nosocomial infections due to MDR P. aeruginosa are an increasing problem. Therapeutical options are few. We describe two haematological patients with severe neutropenia and systemic infection due to MDR P. aeruginosa treated successfully with colistin plus ceftazidime. Severe adverse events were not described.
- Published
- 2006