1. Silica network improve the effect of fludarabine and paclitaxel on HCT8 cell line.
- Author
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Voicu G, Anghel AG, Badea M, Bordei E, Crantea G, Gavrilă RI, Grecu A, Jercan DA, Nicolae BC, Vochiţoaia GC, Tchinda K, Holban AM, Bleotu C, and Grumezescu AM
- Subjects
- Biocompatible Materials pharmacology, Cell Shape drug effects, Endothelial Cells drug effects, Endothelial Cells metabolism, Humans, Microscopy, Electron, Scanning, Spectrophotometry, Infrared, Tumor Cells, Cultured, Vidarabine pharmacology, X-Ray Diffraction, Paclitaxel pharmacology, Silicon Dioxide chemistry, Vidarabine analogs & derivatives
- Abstract
This paper reports the potential of silica network to sensitize tumor cells and stimulate antitumor toxicity of fludarabine (FLU) and paclitaxel (PAC) against HCT8 cells. SiO₂, SiO₂/FLU and SiO₂/PAC nanostructured materials were characterized by X-Ray Diffraction, Scanning Electron Microscopy, InfraRed Microscopy and in vitro biological assays. When using SiO₂/PAC, it can be observed that the cytostatic effect of PAC is boosted only at high concentrations of this material. On the other hand, in the case of SiO₂/FLU, data showed an enhancement in the cytostatic activity of FLU by up to 25%, also when using this nanomaterial in low doses. These data represent preliminary study on the impact on silica nano-networks in targeted delivery and controlled release of antitumor drugs and they may be efficiently used for future biomedical applications in cancer therapy.
- Published
- 2014