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Kidney is a major metabolic organ of human body. Amino acids are not only the basic components of protein， but also important metabolites in human body. Recent researches have demonstrated that amino acids play an important role in the pathophysiological development of various renal diseases. Through detecting the changes of amino acid spectrum in patients with different renal diseases， amino acid metabonomics may help to make early screening and diagnosis of the disease， guide later treatment and predict clinical outcomes. This review summarized the applications of amino acid metabonomics and discussed the clinical value of amino acid metabonomics in renal diseases.

Disulfiram is widely applied for treating chronic alcoholism. In recent years, researchers have proposed specific anti-cancer mechanisms by disulfiram, such as arresting the activity of acetaldehyde dehydrogenase （ALDH） and boosting intracellular reactive oxygen species （ROS）（reactive oxygen species）. A higher concentration of ROS suppressed the activity of nuclear factor kappa-B （NF-κB） and promoted the conjugation between ROS and nuclear protein localization protein 4 （nuclear protein localization protein 4）. Conjugation of NPL4, an inhibition of FROUNT protein and anti-cancer activity of disulfiram have been demonstrated in various cancer models. Anti-glomerular basement membrane glomerulonephritis is one type of acute glomerulonephritis. Upon a definite diagnosis, it should be promptly treated for relieving symptoms and improving outcomes. Disulfiram could antagonize C-C chemokine receptor type 2 and C-C chemokine receptor type 5 through suppressing C-C chemokine receptor type 2/C-C chemokine receptor type 5, CCR-2/CCR-5） and FROUNT protein interacted to suppress the migration, aggregation and activation of macrophages for alleviating anti-glomerular basement membrane type glomerulonephritis. It indicated that disulfiram had some potential therapeutic value. This review focused upon the molecular mechanism of disulfiram. And disulfiram may become a new agent for anti-glomerular basement membrane glomerulonephritis.