Search

The genetic tests of the preimplantation human embryo mainly include: preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS). PGD based on PCR and FISH has been used to detect the single gene disorders and inherited chromosome abnormalities for the last 20 years. PGS with the same technology in PGD was used to detect aneuploidy chromosomes in embryos, to select those embryos with normal chromosomes for IVF transfer. It has been applied in those patients of advanced age, repeated implantation failure, repeated miscarriages and severe male factor infertility. There are dramatic changes in the PGD methodology. Both array --comparative genomic hybridization and single nucleotide polymorphism arrays have been introduced into clinical practice for PGD and PGS. In this review, we introduced some new methods and controversies in the field of PGD/PGS. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the effects of fertility-preserving surgery on the efficacy and fertility in patients with borderline ovarian tumor (BOT). Methods: The clinical data of 51 patients with BOT receiving fertility-preserving treatments were retrospectively analyzed, including surgery, relapse, postoperative menstruation and pregnancy. The correlation was also analyzed between chemotherapy, comprehensive surgical staging and relapse. Results: Among the 51 patients, 30 cases were S-BOT, 7 cases accepted comprehensive surgical staging, 10 cases accepted chemotherapy after surgery, and 13 patients relapsed. Of 8 patients who want pregnancy, 3 patients succeeded. Conclusions: Fertility--preserving treatments are effective and feasible ways for patients with BOT. Adnexectomy may be the best way for fertility -- preserving treatments. Chemotherapy and comprehensive surgical staging cannot reduce the relapse rate. Recurrence cases can choose fertility-preserving surgery again. [ABSTRACT FROM AUTHOR]