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Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Polycystic ovary syndrome (PCOS) is a highly heterogeneous gynecological endocrine disease with clinical manifestations of ovulation disorders, menstrual disorders, hirsute, acne and even infertility. It is often accompanied by metabolic disorders such as obesity, insulin resistance (IR) and dyslipidemia. The pathogenesis of PCOS remains unclear. IR is the main pathological basis of PCOS, which is closely related to the changes of reproductive function such as abnormal level of sex hormones, abnormal follicle development and the reduced endometrial receptivity. Gut microbiome, known as the "second genome of human body", plays a variety of functions in maintaining the homeostasis of the host′ s internal environment, such as preventing pathogens from invading the host, regulating absorption and metabolism of nutritional materials, and maintaining the stability of immune system and nervous system. In recent years, many studies have reported that the changes of gut microbiome composition can cause IR through endotoxemia, bile acid, chronic low-grade inflammation and other ways, thus promoting the occurrence and development of PCOS. [ABSTRACT FROM AUTHOR]

In assisted reproductive technology (ART), the trigger option is part of the individualized treatment. Based on the individual differences of patients, the choice of trigger scheme is very important. The optimal trigger scheme can improve the oocyte maturation rate and oocyte harvest rate without affecting fertilization, embryo development and euploidy rate, and reduce the incidence of ovarian hyperstimulation syndrome (OHSS). Currently, the most commonly used triggers in clinical practice are human chorionic gonadotropin (hCG) trigger and gonadotropin releasing hormone agonist (GnRHa) trigger, while the other triggers are rarely used. However, the only two schemes of hCG trigger and GnRHa trigger are insufficient to provide the individualized treatment for all of the patients. The advantages and controversies of different trigger schemes are reviewed in order to guide clinicians to provide the individualized trigger schemes for patients. [ABSTRACT FROM AUTHOR]