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Objective: To study the effect of early enteral immunonutrition intervention on gastrointestinal hormones, stress hormones and immune response after pancreatic cancer surgery. Methods: A total of 68 patients who received radical operation for pancreatic cancer in Chengdu Third People’s Hospital between May 2015 and February 2017 were selected as the research subjects and randomly divided into TPF-T group and TP group who received early postoperative enteral immunonutrition intervention and conventional enteral nutrition intervention respectively. The levels of gastrointestinal hormones MTL, GAS, CGRP, Ghrelin and stress hormones ACTH, Cor,R, AT-II, ALD in serum as well as the levels of immune cells CD4+T, CD8+T, NKT, Treg, Breg, MDSC in peripheral blood were detected before surgery as well as 3 d and 7 d after surgery. Results: 3 d and 7 d after surgery, MTL, GAS, CGRP and Ghrelin levels in serum as well as CD4+T cell, CD8+T cell and NKT cell levels in peripheral blood of both groups of patients were significantly lower than those before surgery while ACTH, Cor, R, ATII and ALD levels in serum as well as Treg, Breg and MDSC levels in peripheral blood were significantly higher than those before surgery, and MTL, GAS, CGRP and Ghrelin levels in serum as well as CD4+T cell, CD8+T cell and NKT cell levels in peripheral blood of TPF-T group were significantly higher than those of TP group while ACTH, Cor, R, AT-II and ALD levels in serum as well as Treg, Breg and MDSC levels in peripheral blood were significantly lower than those of TP group. Conclusion: Early postoperative enteral immunonutrition intervention can regulate the gastrointestinal hormone secretion, inhibit stress response and improve immune response.