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Copyright of Journal of Clinical Neurosurgery / Linchuang Shenjingwaike Zazhi is the property of Editorial Board of Journal of Clinical Neurosurgery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To study the expression of miR-1224-5p in glioma and its effect on the proliferation of human glioma cells. Methods The expression of miR-1224-5p in glioma tissues of different grades were analyzed within the Chinese Glioma Genome Atlas expression Dataset(CGGA) and were verified by in situ hybridization. The correlation between the expression of miR-1224-5p and the clinical suvival of glioblastoma patients was analyzed. The miR-1224-5p oligonucleotides were transfected into U251 and U87 glioma cells, the effect of up-regulation of miR-1224-5p on cell proliferation was tested by CCK8 assay. Results The expression of miR-1224-5p in human glioma tissue negatively correlated with tumor pathological grade. Low-expression of miR-1224-5p associated with poor survival in glioblastoma patients. Up-regulation of miR-1224-5p suppressed proliferation in glioma cells.Conclusion The expression level of miR-1224-5 p relates with grading and clinlical prognosis in glioma. miR-1224-5p inhibits the proliferation in glioma cells. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Neurosurgery / Linchuang Shenjingwaike Zazhi is the property of Editorial Board of Journal of Clinical Neurosurgery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)