1. Gold-Catalyzed Cyclization of Ynamides and Propargylic Carboxylates
- Author
-
Eva Rettenmeier, Marcel Wieteck, and A. Stephen K. Hashmi
- Subjects
chemistry.chemical_compound ,Cycloisomerization ,chemistry ,Reactivity (chemistry) ,Organic synthesis ,Triple bond ,Metathesis ,Combinatorial chemistry ,Cycloaddition ,Catalysis - Abstract
Over the past few years new synthetic methodologies for the preparation of ynamides have led to a huge increase in their use as highly variable building blocks in organic synthesis. Owing to the presence of an electron-withdrawing group ynamides show a perfect balance between stability and reactivity. Furthermore, due to their strongly polarized triple bond, ynamides show a large variety of reactions possibilities. Among these there are, for example, addition at the αor β-position, cycloaddition, ring-closing metathesis, cycloisomerization. Figure 1 shows the reactivity of ynamides bearing an electron-withdrawing group.
- Published
- 2013
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