1. Anti-protozoal activity of diamine derivatives.
- Author
-
Giordani RB, Araújo DP, Duarte M, Zuanazzi JA, Tasca T, and De Almeida MV
- Subjects
- Giardia lamblia drug effects, Structure-Activity Relationship, Trichomonas vaginalis drug effects, Antiprotozoal Agents pharmacology, Diamines pharmacology
- Abstract
Ten N-monoalkylated diamines were synthesized and evaluated for in vitro activities against Trichomonas vaginalis and Giardia lamblia. Several compounds displayed a good inhibition of parasite growth, with MIC less or equal to 20μg/mL. N-hexadecil-1,4-butanediamine was found to be the most active compound in vitro against T. vaginalis with MIC of 2.5μg/mL, twice more active in comparison to the reference drug metronidazole (MTZ). Seven of the studied compounds showed a better anti-G. lamblia activity than MTZ., (Copyright © 2010. Published by Elsevier SAS.)
- Published
- 2011
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