1. 4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle: A promising scaffold towards bioactive molecules.
- Author
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Plescia F, Maggio B, Daidone G, and Raffa D
- Subjects
- Animals, Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents pharmacology, Anticonvulsants chemistry, Anticonvulsants pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Antioxidants chemistry, Antioxidants pharmacology, Antitubercular Agents chemistry, Antitubercular Agents pharmacology, Benzothiazoles chemistry, Bronchodilator Agents chemistry, Bronchodilator Agents pharmacology, Humans, Molecular Structure, Nitrogen chemistry, Oxygen chemistry, Quinazolinones pharmacology, Sulfur chemistry, Thiazoles chemistry, Quinazolinones chemistry
- Abstract
The quinazolinone nucleus represents, among the class of fused heterocycles, a very important scaffold to obtain molecules with biological activities. A review of literature revealed how such kind of fused heterocycles, coming from natural or synthetic source, are associated with a wide range of biological activities. This review is mainly directed towards the 4-(3H)-quinazolinones N-3 substituted with a five membered heterocycle in which all the possible combinations of nitrogen, sulfur and oxygen atoms are present., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier Masson SAS. All rights reserved.)
- Published
- 2021
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