1. Cyclopentanone ring-cleaved pleuromutilin derivatives.
- Author
-
Springer DM, Bunker A, Luh BY, Sorenson ME, Goodrich JT, Bronson JJ, DenBleyker K, Dougherty TJ, and Fung-Tomc J
- Subjects
- Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Diterpenes chemical synthesis, Diterpenes chemistry, Diterpenes pharmacology, Microbial Sensitivity Tests, Polycyclic Compounds, Staphylococcus aureus drug effects, Streptococcus pneumoniae drug effects, Structure-Activity Relationship, Pleuromutilins, Anti-Bacterial Agents chemical synthesis
- Abstract
Ring-cleaved pleuromutilin derivatives comprised of a [5.3.1] bicyclic core structure have been synthesized and evaluated in vitro as antibacterial agents. Four of the compounds described were found to have MICs
- Published
- 2007
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