1. Therapeutic promises of ginkgolide A: A literature-based review.
- Author
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Sarkar C, Quispe C, Jamaddar S, Hossain R, Ray P, Mondal M, Abdulwanis Mohamed Z, Sani Jaafaru M, Salehi B, Islam MT, Faizal Abdull Razis A, Martorell M, Pastene-Navarrete E, and Sharifi-Rad J
- Subjects
- Animals, Anti-Anxiety Agents isolation & purification, Anti-Anxiety Agents therapeutic use, Anti-Inflammatory Agents isolation & purification, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use, Antineoplastic Agents, Phytogenic isolation & purification, Antineoplastic Agents, Phytogenic pharmacology, Antineoplastic Agents, Phytogenic therapeutic use, Ginkgolides isolation & purification, Humans, Lactones isolation & purification, Plant Leaves, Platelet Activating Factor metabolism, Ginkgo biloba, Ginkgolides pharmacology, Ginkgolides therapeutic use, Lactones pharmacology, Lactones therapeutic use, Platelet Activating Factor antagonists & inhibitors
- Abstract
Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. It is known for its inflammatory and immunological potentials. This review aims to sketch a current scenario on its therapeutic activities on the basis of scientific reports in the databases. A total 30 articles included in this review suggests that ginkgolide A has many important biological activities, including anti-inflammatory, anticancer, anxiolytic-like, anti-atherosclerosis and anti-atherombosis, neuro- and hepatoprotective effects. There is a lack of its toxicological (e.g. toxicity, cytotoxicity, genotoxicity and mutagenitcity) profile. In conclusion, ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders. More studies are necessary on this hopeful therapeutic agent., (Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Published
- 2020
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