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1. Synthesis and antitumor activity of alkyltriazenopyrazoles.

Author

Zakharieva RD, Spassova MK, Karaivanova MC, and Golovinsky EV

Subjects
Adenocarcinoma drug therapy, Animals, Leukemia L1210 drug therapy, Mice, Pyrazoles pharmacology, Structure-Activity Relationship, Triazenes pharmacology, Antineoplastic Agents chemical synthesis, Pyrazoles chemical synthesis, Triazenes chemical synthesis
Abstract

The chemical synthesis of certain mono- and bis-dialkyltriazenopyrazoles is described. In antitumor studies it was found that none of the compounds produced increase in life span (ILS) of L 1210 bearing mice or inhibition of adenocarcinoma 755 growth above the criteria established. The introduction of a second triazenogroup increases the toxicity of the compounds tested.

Published
1984
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2. Synthesis, structure and antibacterial activity of some alkyltriazenopyrazoles.

Author

Spassova MK and Golovinsky EV

Subjects
Chemical Phenomena, Chemistry, Microbial Sensitivity Tests, Pyrazoles pharmacology, Anti-Bacterial Agents chemical synthesis, Bacteria drug effects, Pyrazoles chemical synthesis, Triazenes chemical synthesis
Abstract

A series of bis-beta-chlorethyl-, dimethyl- and diethyltriazenopyrazoles (I-IV) were synthesized. By the method of IR spectroscopy the most probable transformation form of I was shown. The compounds were tested as antibacterial agents on a series of bacterial species. It was established that only one of them (VI) possessed a low inhibitory effect. All the rest inhibited strongly the growth of Staphylococcus aureaus 209 and E. coli 387.

Published
1977
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