1. Nitric oxide: A new possible biomarker in heart failure? Relationship with pulmonary hypertension secondary to left heart failure.
- Author
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Bonafede RJ, Calvo JP, Fausti JMV, Puebla S, Gambarte AJ, and Manucha W
- Subjects
- Animals, Biomarkers metabolism, Heart Failure complications, Humans, Hypertension, Pulmonary physiopathology, NADP metabolism, Prognosis, Reactive Oxygen Species metabolism, Superoxide Dismutase metabolism, Heart Failure physiopathology, Hypertension, Pulmonary etiology, Nitric Oxide metabolism
- Abstract
Heart failure (HF) is a growing medical problem and it is of interest to study new biomarkers for better characterisation. In this sense, nitric oxide, reactive oxygen species (ROS), NADPH, and superoxide dismutase (SOD) were evaluated, along with their possible predictive value in patients with HF. An analysis was also performed on the potential differences between patients with and without secondary pulmonary hypertension (SPH), considered to have a worse prognosis. A significant decrease of nitric oxide and SOD was noted in HF, whereas ROS and NADPH were increased. These results agree with the pathophysiological changes characteristic of HF. It was also demonstrated that in patients with HF and SPH that nitric oxide and SOD were decreased when compared to HF without SPH, whereas ROS and NADPH were increased. Therefore, our results suggest that nitric oxide, ROS, NADPH, and SOD, could be considered as possible markers in HF, and could also characterise patients with SPH., (Copyright © 2017 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2017
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