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Cardiac hypertrophy is a common myocardial structural abnormality which may cause heart failure. Many studies have shown that cardiac hypertrophy can be induced by hyperthyroidism. Ligand-gated potassium channels have been reported to be involved in various biological processes in the cardiovascular system, such as GPCR coupled K ACh and metabolism sensor K ATP channel. It is unclear whether the gene expression of K ACh and K ATP was altered in hyperthyroid rabbit atria. We aimed to investigate the expression of K ACh and K ATP genes in rabbit atria in our experimental model. We established an effective hyperthyroidism-induced cardiac hypertrophy animal model through an injection of T4. H&E staining and RT-PCR were used to observe the histomorphological damages and alteration of gene expression. The results showed that the heart weight, heart rate significantly increased in T4-treated rabbits. The systolic pressure increased from 115.60 mmHg to 152.6 mmHg in T4-treated rabbits. The expression of K ACh and K ATP genes was decreased in the atria of hyperthyroidism-induced cardiac hypertrophied rabbits. These findings indicated that the decreased gene expression of K ACh and K ATP may be related to hyperthyroidism-induced cardiac hypertrophy and atrial fibrillation., Competing Interests: None., (IJCEP Copyright © 2022.)