1. The investigation of glucose metabolism and insulin secretion in subjects of chronic hepatitis B with cirrhosis.
- Author
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Guo CH, Sun TT, Weng XD, Zhang JC, Chen JX, and Deng GJ
- Subjects
- Adult, Aged, Blood Glucose analysis, C-Peptide blood, Female, Glucose Tolerance Test, Humans, Insulin blood, Insulin Resistance physiology, Insulin Secretion, Liver Cirrhosis virology, Male, Middle Aged, Pancreas metabolism, Glucose metabolism, Hepatitis B, Chronic complications, Insulin metabolism, Liver Cirrhosis metabolism
- Abstract
Aims: To investigate the situations of abnormal glucose metabolism and dysfunction of pancreatic islet beta cells in subjects of chronic hepatitis B (CHB) with cirrhosis., Methods: 106 hepatitis B virus (HBV) positive subjects with liver cirrhosis as well as with different grade of Child-Pugh and 37 healthy subjects were included in this study. The oral glucose tolerance test (OGTT), C-peptide and insulin release test were detected. Plasma glucose and insulin levels were analyzed periodically for 2 h after oral glucose loading., Results: There was no significant difference in the level of fasting plasma glucose and C-peptide between cirrhosis group and control group (P>0.05). The levels of OGTT 2 h glucose, insulin and C peptide were significantly higher in cirrhosis group than control group (P<0.01). Peak plasma glucose levels were obtained at 60 min in normal group and cirrhosis group. The peak insulin and C-peptide response occurred at 60 min in normal group, whereas it was delayed to 120 min in cirrhosis group. There was a significant difference between two groups in the pattern of plasma glucose levels at corresponding time points (P<0.05). The OGTT 2 h glucose and insulin levels were positively correlated with Child-Pugh Score (r1 = 0.389, r2 = 0.508, P<0.01)., Conclusion: These findings implied that there was a certain degree of insulin resistance and abnormal glucose metabolism in the patients with liver cirrhosis.
- Published
- 2015