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Waldenström's disease is a rare lymphoproliferative syndrome in the bone marrow and sometimes in lymphoid organs which secretes high amounts of monoclonal immunoglobulin M into serum. It can remain indolent for years and rarely affects the kidney, with intraglomerular rather than intratubular damage being predominant, in contrast to multiple myeloma. Different studies identified AL amyloidosis as the most frequent renal lesion, followed by cryoglobulinemic glomerulonephritis. Signs and symptoms may be unspecific, as well as renal manifestations, so collaboration between nephrologists, hematologists, and pathologists is crucial to establish the role of paraprotein in the development of renal damage. We present an atypical case of Waldenström's disease that had a minimal monoclonal peak and clinically debuted with nephritic and nephrotic syndromes. The diagnosis was cryoglobulinemic glomerulonephritis. Currently, there are numerous treatment options, without enough evidence yet to establish a standardised treatment., Competing Interests: The authors declare no conflict of interest. Figure 1.Optical microscopy: glomeruli with nodular pattern, with massive eosinophilic deposits in capillaries. The areas without deposits showed increased cellularity and mesangial matrix, with polymorphonuclear leukocytes and monocytes, and focal images of double contours.Figure 2.Electron microscopy: fibrillar material with microtubular foci in the intracapillary and subendothelial region, compatible with cryoglobulin deposits. Table 1.Evolution just after initiation of treatment, with normalization of renal function and disappearance of nephrotic and nephritic syndrome. 11/08/202112/07/202101/05/202201/26/202203/10/202206/15/2022Hemoglobin (g/dL)10.510.310.412.5Creatinine (g/dL)1.591.551.211.261.280.86Estimated glomerular filtration rate (CKD-EPI, mL/min/1.73 m2)38.1339.3353.0550.0349.5680.16Proteinuria (g/24h)6,8282,9933,7422,156248254Urine red blood cells (red blood cells per high power field)30 – 5030 – 5030 – 5020 – 301 – 51 – 3IgM peak (g/dL)0.580.490.320.350.410.4κ free chains (mg/L)22.520.9720.4525.2626.7418.17λ free chains (mg/L))16.9218.4516.2818.218.1113.28κ/λ ratio1.331.131.261.391.481.37, (© Dustri-Verlag Dr. K. Feistle.)