1. ASSOCIATION OF BCL11 AGENETIC VARIANT (RS11886868) WITH HEMOGLOBIN F LEVEL IN β-THALASSEMIA MAJOR IN BABYLON PROVINCE, IRAQ.
- Author
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Noor Ali Hussein and Al-Harbi, Hussein Jasim
- Subjects
BCL genes ,SINGLE nucleotide polymorphisms ,FETAL hemoglobin ,BETA-Thalassemia ,HARDY-Weinberg formula ,GENETIC regulation - Abstract
The current study aimed to assess the association of Single nucleotide Polymorphism, (rs11886868) in BcL11A gene with Fetal hemoglobin (HbF) level in β-thalassemia major patients in Babylon Province (Iraq), by enrolling individual of Arab ancestry. A total of 70 β-thalassemia major patients and 30 normal individual were enrolled Family history and HbF assay. All patients were transfusion depend with age mean (15.6 ± 1.20 years). On the other hand the selected control do not have history of family for thalassemia and doesn't have any disease with mean age (14.1 ± 0.7 years). For genotyping a ( PCR - RFLP) method was employed. Concerning BCL11A, rs11886868, there werenon significantly differences in allele frequencies andgenotypic between β- thalassemia major and control groups and was in agree with HARDY-WEINBERG equilibrium distribution. A significant (p <0.05) difference was observed in the mean level of Fetal hemoglobinamong the genotypes. Fetal hemoglobin percentage was found to be high in CC (74.70±5.55) genotype carriers individual followed by TT (65.14 ±9.38) and CT (56.53±5.91). [ABSTRACT FROM AUTHOR]
- Published
- 2018